Evaluation of the impact of serogroup C meningococcal disease vaccination program in Brazil and its regions: a population-based study, 2001-2013

Moraes, Camile de; Moraes, José Cássio de; Silva, Gabriela Drummond Marques da; Duarte, Elisabeth Carmen

doi:10.1590/0074-02760160173

Cited by 12 publications

(10 citation statements)

References 25 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, previous studies have demonstrated that SINAN data was able to detect variations in the historical trends of the incidence and serogroup distribution of invasive disease. 19 , 20 The inclusion of the laboratory results from the Adolfo Lutz Institute database (the National reference laboratory for invasive diseases in Brazil) in the analysis also proved to be an important tool to increase the sensitivity of identified cases. 21 Second, despite an improvement in the quality of diagnosis observed during the study period, particularly in determined states from the South, Central-West and Southeast regions, where molecular-based typing diagnosis was incorporated in the surveillance system, the quality of diagnosis is still highly heterogeneous in the diverse regions, with a significant proportion of the cases reported without identification of the causing-serogroup (overall, only 44.5% of the cases reported during the study period were laboratory-confirmed and with information on serogroup), leading to a substantial underestimation of the true serogroup-specific incidence rates of disease.…”

Section: Discussionmentioning

confidence: 99%

A critical analysis of serogroup B meningococcal disease burden in Brazil (2001–2015): implications for public health decisions

Chicuto

Moraes

et al. 2020

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

The recent licensure of two different serogroup B recombinant protein meningococcal vaccines in Brazil emphasizes the importance of a better knowledge of the real burden of serogroup B meningococcal (MenB) disease to establish evidence-based vaccination policies. We performed an observational, descriptive study, from 2001 to 2015, analyzing the incidence and case fatality rates (CFR) of MenB disease in Brazil, according to age group and region. In the absence of any vaccine use targeting MenB disease, a significant decline of 90% in the overall incidence rates of MenB disease was observed (from 0.55 cases/100,000 habitants in 2001 to 0.05 in 2015), with declines found in all age groups during the study period. The highest incidence rates were consistently observed in infants and children 1-4 year of age, whereas adults ≥ 60 years experienced the highest CFR (33.9%). The proportion of cases with serogroup identified increased from 37.1% in 2001 to 51.5% in 2015. Despite an improvement in recent years, the quality of diagnosis is highly heterogeneous in the diverse regions, presenting important deficiencies that still prevent the possibility of a robust and reliable analysis of the burden of the meningococcal disease in Brazil. Based on the findings of this study and taking in account the unlikely indirect effect associated with the use of the new recombinant serogroup B protein vaccines, infants < 1 year is the age group to be prioritized when considering the implementation of routine immunization programmes with MenB vaccines.

show abstract

Section: Discussionmentioning

confidence: 99%

A critical analysis of serogroup B meningococcal disease burden in Brazil (2001–2015): implications for public health decisions

Chicuto

Moraes

et al. 2020

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

show abstract

“…However, there are exceptions (Table S1) [24]. For instance, in 2010, Brazil introduced a MenC vaccine into their national immunization program in response to an increased incidence of IMD among infants and young children and recurring outbreaks throughout the country [25,26]. The vaccine was administered at age 3 and 5 months, with a booster dose given at age 12-15 months.…”

Section: Surveillance Disease and Vaccinationmentioning

confidence: 99%

Carriage of Neisseria Meningitidis in Low and Middle Income Countries of the Americas and Asia: A Review of the Literature

2020

View full text Add to dashboard Cite

Introduction: Meningococcal colonization, or carriage, can progress to invasive meningococcal disease, a serious public health concern, with rapid progression of disease and severe consequences if left untreated. Information on meningococcal carriage and epidemiology in low/middle income American and Asian countries remains sparse. These data are crucial to ensure that appropriate preventive strategies such as vaccination can be implemented in these regions. The goal of this study was to summarize the Neisseria meningitidis carriage literature in low and middle income countries of the Americas and Asia. Methods: Target countries were categorized as low and middle income according to the International Monetary Fund classification of low income/developing economies and middle income/emerging market economies, respectively. A PubMed search identified Englishlanguage publications that examined carriage in these countries. Studies reporting the epidemiology of N. meningitidis carriage or assessing risk factors for carriage were included. Results: Fourteen studies from the Americas [Brazil (n = 7), Chile (n = 3), and Colombia, Cuba, Mexico, and Paraguay (n = 1 each)] and nine from Asia [China (n = 2), India (n = 3), and Malaysia, Nepal, Philippines, and Thailand (n = 1 each)] were identified; an additional Cuban study from the authors' files was also included. Studies were not identified in many target countries, and substantial diversity was observed among study methodologies, populations, and time periods, thereby limiting comparison between studies. The carriage rate in the Americas ranged from 1.6% to 9.9% and from 1.4% to 14.2% in Asia. Consistent risk factors for carriage were not identified. Conclusions: There is a lack of comprehensive and contemporary information on meningococcal carriage in low and medium income countries of the Americas and Asia. Future Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare. 11962566.

show abstract

“…In a preliminary analysis of the early impact of the routine infant MCC vaccination program in Brazil, the authors could observe significant decreases in incidence rates only among age groups that were vaccinated. 23 More recently, other studies that analyzed the effects of the MCC vaccination after three 24 and four 25 years of its introduction into the Brazilian NIP, also concluded that the impact on disease rates in Brazil could be observed only among vaccine-eligible age groups.…”

Section: Discussionmentioning

confidence: 99%

Impact of meningococcal C conjugate vaccination programs with and without catch-up campaigns in adolescents: Lessons learned from Bahia, Brazil

Macedo

Ferreira

Feitosa

et al. 2018

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

The significant increase in the incidence rates and ongoing outbreaks of serogroup C meningococcal (MenC) disease, associated with the sequence type-103 complex, motivated the incorporation of the meningococcal C conjugate (MCC) vaccine in the routine immunization program in the State of Bahia, Brazil in early 2010, targeting children younger than 5 years of age. In its capital, Salvador, the program also included a catch-up campaign for individuals 10-24 years of age. We performed an observational, ecological study, analyzing data collected from 2007 to 2015, to compare the impact of these two immunization strategies on meningococcal disease incidence and mortality rates. In Salvador, following the vaccination program, a dramatic early impact on MenC disease and mortality rates could be observed, with significant reductions in incidence rates of MenC disease in all age groups, including individuals that were too old to have been vaccinated, indicating the presence of herd protection. Compared to the pre-vaccine period, a virtual disappearance of MenC disease was observed in 2015. However, in the state of Bahia (excluding the city of Salvador), no herd protection could be observed, with significant impact only among vaccine-eligible children within 5 years of introduction of the MCC vaccination program. These results highlight the importance of catch-up campaigns, including adolescents and young adults, to induce herd protection compared to immunization strategies restricted to infants and young children. This information is crucial for identifying optimal immunization policies and future strategies, focused on adolescents, to optimize the impact of MCC vaccination programs.

show abstract

Evaluation of the impact of serogroup C meningococcal disease vaccination program in Brazil and its regions: a population-based study, 2001-2013

Cited by 12 publications

References 25 publications

A critical analysis of serogroup B meningococcal disease burden in Brazil (2001–2015): implications for public health decisions

A critical analysis of serogroup B meningococcal disease burden in Brazil (2001–2015): implications for public health decisions

Carriage of Neisseria Meningitidis in Low and Middle Income Countries of the Americas and Asia: A Review of the Literature

Impact of meningococcal C conjugate vaccination programs with and without catch-up campaigns in adolescents: Lessons learned from Bahia, Brazil

Contact Info

Product

Resources

About