Serological and molecular retrospective analysis of hepatitis E suspected cases from the Eastern Brazilian Amazon 1993-2014

Souza, Alex Júnior Souza de; Malheiros, Andreza Pinheiro; Sarmento, Vânia Pinto; Resende, Fabrício de Souza; Alves, Max Moreira; Nunes, Heloisa Marceliano; Soares, Manoel do Carmo Pereira; Sá, Lílian Rose Marques de

doi:10.1590/0037-8682-0465-2018

Cited by 5 publications

(6 citation statements)

References 14 publications

(10 reference statements)

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“…HEV RNA does not last long and cannot be detected in the blood about 3 weeks after onset of symptoms. The virus continued to spread in feces for a further 2 weeks ( Souza et al, 2019 ). HEV IgM appears early and disappears over 4–5 months ( Favorov et al, 1992 ).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Characteristics and Clinical Manifestations of Hepatitis E in a Tertiary Hospital in China: A Retrospective Study

Fang

Zhang

et al. 2022

Front. Microbiol.

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BackgroundHepatitis E virus (HEV) infection is the most common cause of acute viral hepatitis worldwide and one of the main causes of death in the last decade, causing chronic hepatitis and liver failure in some populations. The aging population and obesity are two major factors threatening human health. Therefore, we want to understand the relationship between these two groups and HEV infection.ObjectivesThe study aimed to analyze the epidemiological, clinical, and laboratory features of HEV infection and evaluate probable high-risk factors for disease progression and the current diagnostic strategies of hepatitis E infection.Study DesignPatients diagnosed with acute hepatitis E with symptoms and liver dysfunction were enrolled. For statistical analysis, clinical features and laboratory findings were collected between the elderly and non-elderly and HEV+ fatty liver disease (FLD) groups. Statistical analysis was performed using Excel and the platform VassarStats, and statistical significance was taken as P < 0.05.ResultsJaundice and the bilirubin peak were significantly deeper, the duration of hospitalization was significantly longer, and the proportion of ascites and liver failure was significantly higher in the elderly group. The aging population is one of the risk factors of severe hepatitis E. Hepatitis E becomes more serious in the HEV + FLD group, although the results did not reach statistical significance.ConclusionThe aging and FLD were suggested to aggravate HEV infection. However, the diagnosis of HEV infection remains a challenge. A prospective study with sufficient sample size is needed to confirm this conclusion.

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Section: Discussionmentioning

confidence: 99%

Epidemiological Characteristics and Clinical Manifestations of Hepatitis E in a Tertiary Hospital in China: A Retrospective Study

Fang

Zhang

et al. 2022

Front. Microbiol.

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“…Such a discrepancy in anti-HEV seropositivity (2% to 38%) between the studies developed in Northeast and Southeast regions cannot be only attributed to socioeconomic/regional differences. Indeed, further studies employing a different EIA reported a lower anti-HEV prevalence (5.3% to 5.9%) in acute non-A-C hepatitis serum samples retrospectively analyzed [ 65 , 66 ] ( Table 1 ). Most likely, it could have been due to the lack of sensitivity/specificity of the first-generation anti-HEV IgG/IgM commercialized EIA used in the earliest serological surveys (1990–2000) ( Table 1 ).…”

Section: Hev Prevalence In the Brazilian Populationmentioning

confidence: 99%

Hepatitis E Virus Research in Brazil: Looking Back and Forwards

Oliveira

Santos

Pinto

2023

Viruses

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Hepatitis E virus (HEV) has emerged as a public health concern in Brazil. From the first identification and characterization of porcine and human HEV-3 strains in the 2000s, new HEV subtypes have been identified from animal, human, and environmental isolates. As new potential animal reservoirs have emerged, there is a need to compile evidence on the zoonotic dissemination of the virus in animal hosts and the environment. The increasing amount of seroprevalence data on sampled and randomly selected populations must be systematically retrieved, interpreted, and considered under the One Health concept. This review focused on HEV seroprevalence data in distinct animal reservoirs and human populations reported in the last two decades. Furthermore, the expertise with experimental infection models using non-human primates may provide new insights into HEV pathogenesis, prevention, and environmental surveillance.

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“…After the recognition of HEV-3 as being responsible for autochthonous hepatitis E in industrialized countries [ 81 , 82 ], HEV studies in Brazil started to focus on cases of acute non-A-C viral hepatitis in order to clarify the potential role of HEV in these undiagnosed cases [ 17 , 28 , 35 ], efforts that still motivate publications nowadays [ 15 , 36 ]. In general, markers of current and/or recent HEV infection (anti-IgM HEV and HEV RNA) have been detected but at a low prevalence, indicating that HEV was not the causal agent of the majority of these acute hepatitis cases.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Hepatitis E Virus in Brazil: A One-Health Approach of the Human-Animal-Environment Triad

Moraes

Mesquita

Dutra

et al. 2021

Animals

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Brazil is the fifth largest country in the world with diverse socioeconomic and sanitary conditions, also being the fourth largest pig producer in the world. The aim of the present systematic review was to collect and summarize all HEV published data from Brazil (from 1995 to October 2020) performed in humans, animals, and the environment, in a One Health perspective. A total of 2173 papers were retrieved from five search databases (LILACs, Mendeley, PubMed, Scopus, and Web of Science) resulting in 71 eligible papers after application of exclusion/inclusion criteria. Data shows that HEV genotype 3 (HEV-3) was the only retrieved genotype in humans, animals, and environment in Brazil. The South region showed the highest human seroprevalence and also the highest pig density and industry, suggesting a zoonotic link. HEV-1 and 2 were not detected in Brazil, despite the low sanitary conditions of some regions. From the present review we infer that HEV epidemiology in Brazil is similar to that of industrialized countries (only HEV-3, swine reservoirs, no waterborne transmission, no association with low sanitary conditions). Hence, we alert for the implementation of HEV surveillance systems in swine and for the consideration of HEV in the diagnostic routine of acute and chronic hepatitis in humans.

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Serological and molecular retrospective analysis of hepatitis E suspected cases from the Eastern Brazilian Amazon 1993-2014

Cited by 5 publications

References 14 publications

Epidemiological Characteristics and Clinical Manifestations of Hepatitis E in a Tertiary Hospital in China: A Retrospective Study

Epidemiological Characteristics and Clinical Manifestations of Hepatitis E in a Tertiary Hospital in China: A Retrospective Study

Hepatitis E Virus Research in Brazil: Looking Back and Forwards

Systematic Review of Hepatitis E Virus in Brazil: A One-Health Approach of the Human-Animal-Environment Triad

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