Clinical and epidemiological aspects of cases of tuberculosis associated with diabetes in Salvador, Bahia, Brazil

Leal, Sâmia Barreto; Araújo, Gleide Santos de; Nery, Joilda Silva; Santos, Carlos Antônio de Souza Teles; Oliveira, Maeli Gomes de; Barreto, Maurício Lima; Pereira, Susan Martins

doi:10.1590/0037-8682-0409-2016

Cited by 3 publications

(16 citation statements)

References 13 publications

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“…Sobre o cenário dos estudos, destaca-se que seis foram realizados no Brasil [16][17][18][19][20][21] , três no México [22][23][24] e os outros na Índia 24 , Etiópia 26 , Espanha 27 , China 28 , Chile 29 e Turquia 30 , apenas um analisou estimativas de diversos países 31 .…”

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“…Considerando os indicadores epidemiológicos de morbidade, os estudos revelaram que algumas regiões do mundo com alta prevalência de DM apresentaram maior incidência de TB 18,20,21,26,27,[29][30][31] . A prevalência da TB entre os pacientes com DM foi maior do que na população em geral 18,26,31 e um estudo apontou que os pacientes com DM apresentaram mais chance de ter TB 18 . Em se tratando de características sociodemográficas dos casos, a comorbidade esteve associada com a idade avançada [16][17][18][19][20][21][22][24][25][26][27]30 , sexo feminino 16-18, 24-26, 29 e renda familiar baixa 18,25 .…”

Section: Resultsunclassified

“…Em relação aos aspectos clínicos, pacientes comórbidos apresentaram maior gravidade nos sintomas do que aqueles sem DM, sendo mais frequentes: tosse, expectoração, hemoptise, febre, fadiga, sudorese noturna, fraqueza, diarreia, cefaleia, dores nas pernas e mal-estar 18,19 . Além disso, tiveram maior chance de apresentar padrões cavitários no raio X de tórax, baciloscopia positiva 17,19,21,22,[27][28]30 , atraso na conversão do escarro [19][20][21][22] , falha no tratamento 16,24,26 e maior chance de desenvolver tuberculose multirresistente (TBMR) 16 .…”

Section: Resultsunclassified

“…Os estudos selecionados nesta revisão indicaram que existe associação positiva entre a prevalência de DM e elevados índices de TB 18,[20][21][22][23]26,27,29,31 . Corroborando com tais achados, pacientes com DM tem maior risco de obter TB, com evidências consistentes de um aumento de duas a quatro vezes no risco de desenvolver TB 32 .…”

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Caracterização clínico-epidemiológica da comorbidade tuberculose/diabetes mellitus: revisão integrativa

et al. 2020

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Objetivo: sintetizar as evidências científicas acerca de características sociodemográficas, indicadores epidemiológicos de morbidade e manifestações clínicas dos casos associados de tuberculose e diabetes mellitus. Método: revisão integrativa da literatura com buscas realizadas nas bases Scopus, Literatura Latino Americana e do Caribe em Ciências da Saúde, Medical Literature Analysis and Retrieval System Online e nos portais National Library of Medicine, Biblioteca Virtual em Saúde Brasil e Scientific Eletronic Library Online, sendo a amostra final foi composta por dezesseis estudos. Resultados: observou-se que a alta prevalência de diabetes contribui para o aumento dos casos de tuberculose. Os pacientes com a comorbidade tendem a apresentar idade avançada, serem do sexo feminino e possuírem renda familiar mais baixa. O diabetes afeta negativamente a gravidade da tuberculose pulmonar, provocando sintomas mais graves. Conclusão: as evidências apontadas têm potencial para guiar as intervenções em saúde e possibilitam a implementação de ações de saúde mais efetivas.

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Caracterização clínico-epidemiológica da comorbidade tuberculose/diabetes mellitus: revisão integrativa

et al. 2020

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Trend and factors associated with Tuberculosis-Diabetes Mellitus comorbidity in a Northeastern Brazilian municipality

et al. 2021

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Objectives: to identify the trend and factors associated with Tuberculosis-Diabetes Mellitus comorbidity in Imperatriz, Maranhão. Methods: epidemiological temporal-series study, conducted in a Northeastern Brazilian municipality. The population consisted of Tuberculosis cases with Diabetes Mellitus-associated aggravation notified in the Notifiable Diseases Information System (SINAN) between 2009 and 2018. We determined the prevalence and trend of comorbidity using Prais-Winsten regressions and to identify associated factors employed Poisson regression. Results: prevalence ranged from 3.23% in 2014 to 19.51% in 2018, with a mean of 11.5% for the period, showing an increasing trend. Age groups 30 to 59 years and ≥ 60 years, education < 8 years, and clinical form of pulmonary Tuberculosis were risk factors for comorbidity. Conclusions: The increasing trend of comorbidity and its associated factors alert us to the need to improve customer service at all levels of health care.

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Clinical, laboratory, and radiographic aspects of patients with pulmonary tuberculosis and dysglycemia and tuberculosis treatment outcomes

et al. 2022

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Objective: To analyze the association of dysglycemia with clinical, laboratory, and radiographic characteristics of patients with pulmonary tuberculosis (PTB), as well as with their tuberculo-sis treatment outcomes. Methods: This was a longitudinal study involving 140 patients diag-nosed with PTB (positive cultures for Mycobacterium tuberculosis or positive Xpert MTB/RIF results from sputum samples). Patients were evaluated at diagnosis (M0), after completing the second month of treatment (M2), and at the end of treatment (MEND). At M0, the pati-ents were classified into three groups: normoglycemia+PTB (NGTB); pre-diabetes melli-tus+PTB (PDMTB), and diabetes mellitus+PTB (DMTB), in accordance with glycated hemoglo-bin levels (< 5.7%, 5.7%-6.4%, and = 6.5%, respectively). Treatment outcomes were classified as favorable (cure or treatment completion) and unfavorable (death, loss to follow-up, or treatment failure). Results: In our sample, 76 patients (61.4%) had dysglycemia, 20 of whom (14.3%) had DM at M0. The patients with dysglycemia, in comparison with those in the NGTB group, more frequently presented with positive sputum smear microscopy (94.2% vs. 75.9%; p = 0.003); cavities (80.2% vs. 63.0%; p = 0.03); bilateral lesions (67.4% vs. 46.0%; p = 0.02); and higher median of affected thirds of the lungs (3.0 vs. 2.0; p = 0.03) on chest radiography. No significant differences regarding outcomes were found among the groups, but tuberculosis lethality was higher in the DMTB group than in the PDMTB and NGTB groups (20% vs. 2.2%). Conclusions: PTB patients with dysglycemia had laboratory and radiographic manifestations indicative of more advanced disease, and the risk of death was higher in the DMTB group. These findings reinforce the recommendation for early screening for DM in patients with newly diagnosed tuberculosis in order to reduce the risk of death during treatment.

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Clinical and epidemiological aspects of cases of tuberculosis associated with diabetes in Salvador, Bahia, Brazil

Abstract: Clinical symptoms differed between patients with TB, with and without DM.

Cited by 3 publications

References 13 publications

Caracterização clínico-epidemiológica da comorbidade tuberculose/diabetes mellitus: revisão integrativa

Caracterização clínico-epidemiológica da comorbidade tuberculose/diabetes mellitus: revisão integrativa

Trend and factors associated with Tuberculosis-Diabetes Mellitus comorbidity in a Northeastern Brazilian municipality

Clinical, laboratory, and radiographic aspects of patients with pulmonary tuberculosis and dysglycemia and tuberculosis treatment outcomes

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