Clinical, laboratory, and therapeutic characteristics of American tegumentary leishmaniasis in the 15 th State Health Division, Northwest Paraná State, Southern Brazil

Nassif, Priscila Wolf; Castilho-Peres, Marcela; Rosa, Ana Paula Zanatta; Silva, Aline Laureano da; Aristides, Sandra Mara Alessi; Lonardoni, Maria Valdrinez Campana; Teixeira, Jorge Juarez Vieira; Silveira, Thaís Gomes Verzignassi

doi:10.1590/0037-8682-0208-2016

Cited by 7 publications

(10 citation statements)

References 24 publications

(43 reference statements)

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“…Elderly people are at higher risk of dying from ACL because they have comorbidities that can be exacerbated with treatment (Brasil, 2017). This finding reinforces the need for a rigorous clinical evaluation before prescription of the drug and more intense monitoring during treatment (Nassif et al, 2016). The fact that there are few deaths may mean that the search for the health system and the diagnosis must be fast, as well as the effective treatment.…”

Section: Discussionsupporting

confidence: 52%

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American cutaneous leishmaniasis associated with degradation of native forest, regardless of economic, social and infrastructure vulnerability

Caldart

Sevá

Ferreira

et al. 2020

Zoonoses and Public Health

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American cutaneous leishmaniasis (ACL) is a notifiable dermatozoonosis with relevant morbidity. The present study aimed to evaluate the epidemiological aspects of cases of ACL reported in Northern Paraná (2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016), as well as to georeference and analyse the influence of economic, social and environmental variables. Data from ACL notification forms were obtained and the patients' houses were georeferenced.Descriptive statistics, calculations of disease incidence and proportion of vegetation cover by municipality, spatial analysis, multiple linear regression and vulnerability analysis by census sector (CS) were performed. One thousand four hundred fiftyone cases of ACL were reported in the 89 municipalities of four regional health (RH). The average incidence of cases per 10,000 inhabitants was as follows: 11.58, 8.79, 4.92 and 4.03 in 18thRH, 15thRH, 16thRH and 17thRH. Peaks of incident cases were observed in 2008, 2012 and 2015. There was a statistically significant difference between the HR when comparing the proportions of the variables gender, age, education level, area of residence, clinical form, diagnostic criteria, response to treatment and drug used in case of failure. It was observed that the lower the proportion of remaining Atlantic Forest, the greater the incidence of ACL in the municipality. With regard to clusters analysis, treatment abandonment clusters were observed in How to cite this article: Caldart ET, Sevá ADP, Pinto-Ferreira F, et al. American cutaneous leishmaniasis associated with degradation of native forest, regardless of economic, social and infrastructure vulnerability. Zoonoses Public Health.

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Section: Discussionsupporting

confidence: 52%

“…Meglumine antimoniate has been used for more than 90 years in Brazil and is the drug of choice for treating ACL (Brasil, 2017), despite having considerable nephrotoxicity (Rath et al, 2003) and parasitic resistance (Croft et al, 2006;Nassif et al, 2016;Pontello Junior et al, 2013;Strazzulla et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

American cutaneous leishmaniasis associated with degradation of native forest, regardless of economic, social and infrastructure vulnerability

Caldart

Sevá

Ferreira

et al. 2020

Zoonoses and Public Health

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“…Leishmaniasis is a group of diseases caused by the Leishmania genus, protozoan parasites that have more than 20 infective species to mammals, which are transmitted by the bite of female phlebotomine during blood meal (Nassif et al, 2016). According to the World Health Organization (WHO), leishmaniasis are neglected tropical diseases endemic in 102 countries of American, European, Asian, and African continents, responsible for 1.3 million new cases and approximately 30,000 deaths annually (Organización Panamericana de la Salud [OPS], 2019).…”

Section: Introductionmentioning

confidence: 99%

Prolyl Oligopeptidase From Leishmania infantum: Biochemical Characterization and Involvement in Macrophage Infection

et al. 2020

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Leishmania infantum is a flagellated protozoan and one of the main causative agents of visceral leishmaniasis. This disease usually affects the human reticuloendothelial system, can cause death and available therapies may lead to serious side effects. Since it is a neglected tropical disease, the incentives for the development of new drugs are insufficient. It is important to know Leishmania virulence factors that contribute most to the disease in order to develop drugs. In the present work, we have produced L. infantum prolyl oligopeptidase (rPOPLi) in Escherichia coli, and investigated its biochemical properties as well as the effect of POP inhibitors on its enzymatic activity and on the inhibition of the macrophage infection by L. infantum. The optimal activity occurred at pH 7.5 and 37 • C in the presence of DTT, the latter increased rPOPLi catalytic efficiency 5-fold on the substrate N-Suc-Gly-Pro-Leu-Gly-Pro-AMC. The enzyme was inhibited by TPCK, TLCK and by two POP specific inhibitors, Z-Pro-prolinal (ZPP, IC 50 4.2 nM) and S17092 (IC 50 3.5 nM). Besides being a cytoplasmic enzyme, POPLi is also found in punctuate structures within the parasite cytoplasm or associated with the parasite plasma membrane in amastigotes and promastigotes, respectively. Interestingly, S17092 and ZPP prevented parasite invasion in murine macrophages, supporting the involvement of POPLi in the invasive process of L. infantum. These data suggest POPLi as a virulence factor that offers potential as a target for designing new antileishmanial drugs.

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“…Dogs and rodents are the main reservoirs of this disease [5]. Leishmaniasis has three main clinical forms, namely Visceral leishmaniasis (VL) (Kala-azar), Cutaneous Leishmaniasis (CL) and Mucocutaneous leishmaniasis (MCL) [6], [7]. In this regard, the CL is a very common form and has the highest prevalence in the world [8], So that the World Health Organization (WHO) has introduced this disease as an important neglected tropical disease.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Study of Cutaneous Leishmaniasis in Neyshabur County, East of Iran (2011-2017)

Sakhaei

Darrudi

Motaarefi

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Cutaneous Leishmaniasis (CL) isn’t a deadly disease, but it has always been taken into consideration due to the long-term involvement of patients with skin. Various factors can play an intervening role in increasing the rate of disease. The present study aimed to evaluate the prevalence and associated factors of disease from 2011-2017 and provide appropriate control strategies for reducing its incidence in Neyshabur county. METHODS: All patients with CL, who had medical records in the health centres of Neyshabur from 2011 to 2017, were examined for conducting this analytical-descriptive study. Data were analyzed by descriptive statistics and chi-square test at a significant level of 0.95 using SPSS V22. RESULTS: Findings indicated that the highest annual incidence was in 2016 (229 patients), and the least incidence was in 2014 (100 patients). The majority of patients were under 10 years of age and 51.7% of patients were male. About 59.5% of patients were living in cities and 35% of them were living in North of Neyshabur city. Hands were the most affected part of the body (56.0%) followed by trunk (1.3%). Most patients (69.9%) were treated with topical regimens. CONCLUSION: This study showed that CL was hypo-endemic in Neyshabur. Also, the disease was more prevalent in urban areas. Therefore, appropriate health measures to improve environmental conditions, public health educations, and the public awareness of the positive impact of early diagnosis of disease in the success of treatment (especially for inhabitance suburbanite) are essential.

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Clinical, laboratory, and therapeutic characteristics of American tegumentary leishmaniasis in the 15 th State Health Division, Northwest Paraná State, Southern Brazil

Cited by 7 publications

References 24 publications

American cutaneous leishmaniasis associated with degradation of native forest, regardless of economic, social and infrastructure vulnerability

American cutaneous leishmaniasis associated with degradation of native forest, regardless of economic, social and infrastructure vulnerability

Prolyl Oligopeptidase From Leishmania infantum: Biochemical Characterization and Involvement in Macrophage Infection

Epidemiological Study of Cutaneous Leishmaniasis in Neyshabur County, East of Iran (2011-2017)

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