Cerebral malaria: A life-threatening complication

Bekçi, Tümay; Çakır, İsmet Miraç; Aslan, Serdar

doi:10.1590/0037-8682-0186-2021

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2023

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“…World Health Organization (WHO) statistics show that five parasites are the main causes of malaria in humans, with Plasmodium falciparum ( P. falciparum ) and Plasmodium vivax ( P. vivax ) posing the greatest malaria threats ( https://www.who.int/ ). Combined, these species caused 241 million malaria cases in 2020, with 627,000 malarial deaths ( 6 ). Leishmaniasis is a neglected tropical disease and the second leading cause of parasite-associated death, with 700,000 to 1 million new cases diagnosed each year ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

The roles of COX-2 in protozoan infection

2023

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Protozoan diseases cause great harm in animal husbandry and require human-provided medical treatment. Protozoan infection can induce changes in cyclooxygenase-2 (COX-2) expression. The role played by COX-2 in the response to protozoan infection is complex. COX-2 induces and regulates inflammation by promoting the synthesis of different prostaglandins (PGs), which exhibit a variety of biological activities and participate in pathophysiological processes in the body in a variety of ways. This review explains the roles played by COX-2 in protozoan infection and analyzes the effects of COX-2-related drugs in protozoan diseases.

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Section: Introductionmentioning

confidence: 99%