The roles of COX-2 in protozoan infection

Wang, Xinlei; Chen, Jie; Zheng, Jiahong

doi:10.3389/fimmu.2023.955616

Cited by 7 publications

(7 citation statements)

References 165 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In ammation is markedly in uenced by prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase 2 (COX-2) [23]. The activation of COX-2 can stimulate a rapid production of PG-endoperoxide and trigger an in ammatory reaction [24]. MMP is an extracellular matrix degrading enzyme that is involved in in ammatory and immune responses [25].…”

Section: Discussionmentioning

confidence: 99%

The analysis of bioinformatics uncovers the interaction genes and immune connection between the fracture and CRPS

Kong,

Wang,

Guo

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Patients with fractures are known to have an increased susceptibility to the development of complex regional pain syndrome (CRPS), yet the precise underlying mechanism of this condition remains inadequately understood. The objective of this study is to identify shared genes between fracture and CRPS and explore their potential molecular mechanisms. Methods The raw data pertaining to facture and CRPS were obtained from the Gene Expression Omnibus (GEO) datasets. Venn plots were utilized to extract the differentially expressed genes (DEGs) that were shared between facture and CRPS. Subsequently, functional enrichment analyses were conducted on these shared genes to identify significant biological functions. The PPI network was employed to visualize the network of the shared genes, and the hub genes were identified using MCODE. The levels of immune infiltration in fracture and CRPS were evaluated using the CIBERSORT algorithm, and the relationship between hub genes and immune cell infiltration was investigated. Additionally, the expression levels of hub genes were examined to explore potential phenotypic subgroups in fractures and CRPS, and the infiltration of immune cells was analyzed across different subcategories. Results A comprehensive analysis revealed the presence of 13 overlapping genes among the DEGs in the fracture and CRPS datasets. The outcomes of functional enrichment analysis suggest that these shared genes primarily participate in immune-related pathways. Furthermore, our investigation identified five hub genes that exhibited up-regulation in both CRPS and fracture patients when compared to healthy individuals. The analysis of immune infiltration revealed an increase in various immune cell populations among patients diagnosed with CRPS and fractures. Furthermore, the hub genes exhibited strong associations with multiple infiltrating immune cells. Based on their shared gene expression profiles, patients with fractures and CRPS were classified into two distinct clusters, namely C1 and C2. Conclusion Our study reveals a close relationship between fracture and CRPS from crosstalk genes, providing clues to further explore the interaction and therapy for fracture and CRPS.

show abstract

Section: Discussionmentioning

confidence: 99%

The analysis of bioinformatics uncovers the interaction genes and immune connection between the fracture and CRPS

Kong,

Wang,

Guo

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The gene encoding PTGS2, also known as cyclooxygenase 2 (COX-2), is located on chromosome 1 ( Mongini et al, 2014 ). PTGS2 is a rate-limiting enzyme in the synthesis of prostaglandins (PGs), which catalyzes the metabolism of arachidonic acid (AA) into various PG products including the precursor prostaglandin H2 (PGH2) and leukotrienes (LTs) ( Wang et al, 2023 ). PTGS2 plays an important role in lung diseases.…”

Section: Discussionmentioning

confidence: 99%

Integration of metabolomics and network pharmacology to reveal the protective mechanism underlying Qibai Pingfei capsule on chronic obstructive pulmonary disease

Xie,

Liu,

Gao

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

In this study, we have employed metabolomics technology in combination with network pharmacology to ascertain the key metabolites and hub genes. The objective was to explore the pathway of Qibai Pingfei Capsule (QBPF) in treating COPD through metabolomics. We identified 96 differential metabolites in the lung tissues of rats belonging to control and model groups, out of which 47 were observed to be critical (VIP >2, p < 0.05). Furthermore, 16 important differential metabolites were reversed after QBPF treatment. Using network pharmacology, we identified 176 core targets of 81 drug-active ingredients. Our comprehensive analysis of network pharmacology and metabolomics enabled us to identify a core target, prostaglandin-endoperoxide synthase 2 (PTGS2), and a core metabolic pathway for glutathione metabolism. Finally, the result of molecular docking showed that PTGS2 had strong binding activity to 18 compounds including Fumarine and Kaempferol, etc.. PTGS2 is a marker of ferroptosis, so we wanted to explore whether QBPF could inhibit ferroptosis in COPD. The results showed that ferroptosis was involved in the pathogenesis of COPD, and QBPF could inhibit the occurrence of ferroptosis. In conclusion, the mechanism of QBPF for treating COPD may be related to PTGS2 expression, glutathione metabolism and ferroptosis.

show abstract

“…COX-2, an inducible COX-enzyme isotype, is one of the most crucial inflammatory factors in both acute and chronic pathological states. 42 It is a functional enzyme participating in prostaglandin production under pathological conditions and is highly expressed in precancerous and malignant lesions. 43 COX-2 is deemed a driving force in the progression of tumors owing to its fundamental role in inflammation, angiogenesis, immunosuppression, and invasiveness.…”

Section: Discussionmentioning

confidence: 99%

Activated platelets facilitate hematogenous metastasis of breast cancer by modulating the PDGFR-β/COX-2 axis

Tang,

Qian,

Zhou

et al. 2023

iScience

View full text Add to dashboard Cite

The roles of COX-2 in protozoan infection

Cited by 7 publications

References 165 publications

The analysis of bioinformatics uncovers the interaction genes and immune connection between the fracture and CRPS

The analysis of bioinformatics uncovers the interaction genes and immune connection between the fracture and CRPS

Integration of metabolomics and network pharmacology to reveal the protective mechanism underlying Qibai Pingfei capsule on chronic obstructive pulmonary disease

Activated platelets facilitate hematogenous metastasis of breast cancer by modulating the PDGFR-β/COX-2 axis

Contact Info

Product

Resources

About