Toxicological profile of deltamethrin in Triatoma brasiliensis (Hemiptera: Reduviidae) in State of Ceará, Northeastern Brazil

Pessoa, Grasielle Caldas D’Ávila; Trevizani, Nathália Abreu Borges; Dias, Letícia Sena; Bezerra, Claudia Mendonça; Melo, Bernardino Vaz de; Diotaiut, Liléia

doi:10.1590/0037-8682-0010-2015

Cited by 8 publications

(10 citation statements)

References 19 publications

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“…However, the actual factors behind the emergence of these phenotypes are unknown and the impact of this on the development of standardized strategies for vector control are unclear (89) (90) . This new context will require endemic countries to build networks of cooperation between laboratories for the analysis of resistance in triatomine populations in a standardized manner, integrating this activity in the process of epidemiological surveillance (88) .…”

Section: Vector Transmissionmentioning

confidence: 99%

2 nd Brazilian Consensus on Chagas Disease, 2015

Dias

Ramos

Gontijo

et al. 2016

Rev. Soc. Bras. Med. Trop.

278

449

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Section: Vector Transmissionmentioning

confidence: 99%

2 nd Brazilian Consensus on Chagas Disease, 2015

Dias

Ramos

Gontijo

et al. 2016

Rev. Soc. Bras. Med. Trop.

278

449

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“…Although, all T . brasiliensis tested until now have been highly susceptible to deltamethrin, an alpha-cyano-substituted pyrethroid insecticide [99], insecticide resistance has been demonstrated for some Chagas disease vectors, including T . infestans [100–102].…”

Section: Discussionmentioning

confidence: 99%

Under-Expression of Chemosensory Genes in Domiciliary Bugs of the Chagas Disease Vector Triatoma brasiliensis

et al. 2016

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BackgroundIn Latin America, the bloodsucking bugs Triatominae are vectors of Trypanosoma cruzi, the parasite that causes Chagas disease. Chemical elimination programs have been launched to control Chagas disease vectors. However, the disease persists because native vectors from sylvatic habitats are able to (re)colonize houses—a process called domiciliation. Triatoma brasiliensis is one example. Because the chemosensory system allows insects to interact with their environment and plays a key role in insect adaption, we conducted a descriptive and comparative study of the chemosensory transcriptome of T. brasiliensis samples from different ecotopes.Methodology/Principal FindingIn a reference transcriptome built using de novo assembly, we found transcripts encoding 27 odorant-binding proteins (OBPs), 17 chemosensory proteins (CSPs), 3 odorant receptors (ORs), 5 transient receptor potential channel (TRPs), 1 sensory neuron membrane protein (SNMPs), 25 takeout proteins, 72 cytochrome P450s, 5 gluthatione S-transferases, and 49 cuticular proteins. Using protein phylogenies, we showed that most of the OBPs and CSPs for T. brasiliensis had well supported orthologs in the kissing bug Rhodnius prolixus. We also showed a higher number of these genes within the bloodsucking bugs and more generally within all Hemipterans compared to the other species in the super-order Paraneoptera. Using both DESeq2 and EdgeR software, we performed differential expression analyses between samples of T. brasiliensis, taking into account their environment (sylvatic, peridomiciliary and domiciliary) and sex. We also searched clusters of co-expressed contigs using HTSCluster. Among differentially expressed (DE) contigs, most were under-expressed in the chemosensory organs of the domiciliary bugs compared to the other samples and in females compared to males. We clearly identified DE genes that play a role in the chemosensory system.Conclusion/SignificanceChemosensory genes could be good candidates for genes that contribute to adaptation or plastic rearrangement to an anthropogenic system. The domiciliary environment probably includes less diversity of xenobiotics and probably has more stable abiotic parameters than do sylvatic and peridomiciliary environments. This could explain why both detoxification and cuticle protein genes are less expressed in domiciliary bugs. Understanding the molecular basis for how vectors adapt to human dwellings may reveal new tools to control disease vectors; for example, by disrupting chemical communication.

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“…There are various physiological resistance mechanisms, including: I) reduced penetration of insecticide resulting from changes to insect cuticle; II) changes in the activity of different enzymes, with variation in the proportions and combinations, but with a signifi cant increase in monooxygenases and esterases; and III) two point mutations (L1014F and L925I) in the second domain of the sodium channel gene protein. Studies of Triatomine resistance to insecticides highlight 3 limitations in the interpretation of results; namely, I) there is wide diversity in methodologies, despite the existence of a single guiding protocol; II) there is a lack of information about the actual impact of resistance ratios in the fi eld; and III) the viability of the methodological criterion used for choosing the susceptibility reference lineage, since some field populations are more susceptible to the SRL (25) (28) (30) (33) . Because it is a complex phenomen and most often multifactorial, we believe that insecticides resistance in triatomine should be evaluated by the eco-epidemiological and environmental context in which Triatomine belong.…”

Section: Discussionmentioning

confidence: 99%

“…The meeting of fi eld populations more susceptible than the SRL (25) (28) (30) (33) reveal the fragility of this criteria.…”

Section: Methodological Difficultiesmentioning

confidence: 99%

History of insecticide resistance of Triatominae vectors

Pessoa

Viñas²,

Rosa

et al. 2015

Rev. Soc. Bras. Med. Trop.

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In the last 15 years, different types of Triatominae resistance to different insecticides have been reported; thus, resistance may be more widespread than known, requiring better characterization and delimitation, which was the aim of this review. This review was structured on a literature search of all articles from 1970 to 2015 in the PubMed database that contained the keywords Insecticide resistance and Triatominae. Out of 295 articles screened by title, 33 texts were selected for detailed analysis. Insecticide resistance of Triatomines is a complex phenomenon that has been primarily reported in Argentina and Bolivia, and is caused by different factors (associated or isolated). Insecticide resistance of Triatominae is a characteristic inherited in an autosomal and semi-dominant manner, and is polygenic, being present in both domestic and sylvatic populations. The toxicological profi le observed in eggs cannot be transposed to different stages of evolution. Different toxicological profi les exist at macro-and microgeographical levels. The insecticide phenotype has both reproductive and developmental costs. Different physiological mechanisms are involved in resistance. Studies of Triatomine resistance to insecticides highlight three defi ciencies in interpreting the obtained results: I) the vast diversity of methodologies, despite the existence of a single guiding protocol; II) the lack of information on the actual impact of resistance ratios in the fi eld; and III) the concept of the susceptibility reference lineage. Research on the biological and behavioral characteristics of each Triatominae species that has evolved resistance is required in relation to the environmental conditions of each region.

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Toxicological profile of deltamethrin in Triatoma brasiliensis (Hemiptera: Reduviidae) in State of Ceará, Northeastern Brazil

Cited by 8 publications

References 19 publications

2 nd Brazilian Consensus on Chagas Disease, 2015

2 nd Brazilian Consensus on Chagas Disease, 2015

Under-Expression of Chemosensory Genes in Domiciliary Bugs of the Chagas Disease Vector Triatoma brasiliensis

History of insecticide resistance of Triatominae vectors

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