2 nd Brazilian Consensus on Chagas Disease, 2015

Dias, João Carlos Pinto; Ramos, Alberto Novaes; Gontijo, Eliane Dias; Luquetti, Alejandro O.; Shikanai-Yasuda, Maria Aparecida; Coura, José Rodrigues; Torres, Rosália Morais; Melo, José Renan da Cunha; Almeida, Eros Antônio de; Oliveira, Wilson de; Silveira, Antônio Carlos; Rezende, Joffre Marcondes de; Pinto, Fabiane Scalabrini; Ferreira, Antônio Walter; Rassi, Anis; Filho, Abílio Augusto Fragata; Sousa, Andréa Silvestre de; Correia, Dalmo; Jansen, Ana Maria; Andrade, Gláucia Manzan Queiroz de; Britto, Constança; Pinto, Ana Yecê das Neves; Campos, Dayse Elisabeth; Abad‐Franch, Fernando; Santos, Silvana Eloi; Chiari, Égler; Hasslocher‐Moreno, Alejandro Marcel; Moreira, Eliane Furtado; Marques, Divina Seila de Oliveira; Silva, Eliane Lages; Marin-Neto, José Antônio; Galvão, Lúcia Maria da Cunha; Xavier, Sérgio Salles; Valente, Sebastião Aldo da Silva; Carvalho, Noêmia Barbosa; Cardoso, Alessandra Viana; Silva, Rafaella Albuquerque e; Costa, Veruska Maia da; Vivaldini, Simone Monzani; Oliveira, Suelene Mamede; Valente, Vera da Costa; Lima, Mayara Maia; Alves, Renato Vieira

doi:10.1590/0037-8682-0505-2016

Cited by 278 publications

(466 citation statements)

References 217 publications

(430 reference statements)

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“…Governments, especially in Latin America, need to give higher priority to this health issue. It is also necessary to mobilize resources and capabilities from different society sectors, such as non-governmental and private organizations to combat and prevent this disease (14).…”

Section: Discussionmentioning

confidence: 99%

Patients with Chagas Disease and Cardiac Arrest Treated at the Emergency Department of a Reference Hospital in Brazil

Vancini

Campanharo

Andrade

et al. 2017

Arch Clin Infect Dis

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People with Chagas disease are at a higher risk of death due to cardiac arrest (CA). Considering that Chagas disease remains a serious health problem in Latin America, studies in this regard are still needed. The aim of this study was to present 2 patients with Chagas that developed CA and were treated at the emergency department of a reference hospital in Brazil (Sao Paulo city). Case one: Male (73 years old and Caucasian) with a history of systemic arterial hypertension, diabetes mellitus, liver cirrhosis, and Chagas disease associated with megacolon and megaesophagus. After cardiac collapse and 30 minutes of cardiopulmonary resuscitation (CPR), unfortunately the patient died. Case two: A female patient (64 years old and Caucasian), with a history of systemic arterial hypertension, obesity, and Chagas disease. After 23 days of hospitalization, pharmacological therapy, and implantation of a cardioverter defibrillator, the patient was discharged. People with Chagas disease are at a higher risk of CA. The researchers believe that a prompt and efficient treatment (advanced life support) allied with educational programs on CA recognition targeted at health professionals and caregivers (basic life support knowledge) could improve the prognoses of these patients.

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Section: Discussionmentioning

confidence: 99%

Patients with Chagas Disease and Cardiac Arrest Treated at the Emergency Department of a Reference Hospital in Brazil

Vancini

Campanharo

Andrade

et al. 2017

Arch Clin Infect Dis

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“…Alberto Novaes Ramos Junior [1] and Andréa Silvestre de Sousa [2], [3] [1]. Federal University of Ceara, School of Medicine, Department of Community Health, Fortaleza, Ceara, Brazil.…”

mentioning

confidence: 99%

“…The high morbidity and mortality burden of Chagas disease is unquestionable, both in endemic and non-endemic settings 1,2 . The globalization of the disease is increasingly recognized and has thereby broadened the debate on the right to health, demanding an integrated response between countries [1][2][3] .…”

mentioning

confidence: 99%

“…The globalization of the disease is increasingly recognized and has thereby broadened the debate on the right to health, demanding an integrated response between countries [1][2][3] . Despite its relevance as a public health problem, great failures persist in national health systems in providing access to diagnosis and treatment for affected people [3][4][5][6] .…”

mentioning

confidence: 99%

“…It is estimated that less than 90% of people who need specifi c treatment actually have access to it 1,7 . Primary health care not only plays a central role in the comprehensive care of people with Chagas disease as well as their families and communities; but also, in the surveillance and control of the disease 1 .…”

mentioning

confidence: 99%

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The continuous challenge of Chagas disease treatment: bridging evidence-based guidelines, access to healthcare, and human rights

Ramos

Sousa

2017

Rev. Soc. Bras. Med. Trop.

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Increased frequencies of circulating CCR5+ memory T cells are correlated to chronic chagasic cardiomyopathy progression

Roffê

Santos

et al. 2019

Journal of Leukocyte Biology

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The infection with the protozoan parasite Trypanosoma cruzi causes Chagas disease, a neglected tropical disease in Latin America and an imported emerging disease worldwide. Chronic Chagasic cardiomyopathy (CCC), a progressive inflammatory and fibrosing disease, is the most prominent clinical form of Chagas disease, culminating in heart failure and high rates of sudden death. CCC pathogenesis is influenced by both host and parasite factors and is proposed to be mostly immune‐driven. Chemokines are crucial players in orchestrating immune cell recruitment to infected tissues and inflammation. Herein, we investigated inflammatory chemokine receptor expression on circulating T cells in patients stratified by CCC severity. Compared to asymptomatic individuals, we found increased percentages of effector CD4+ T cells and central memory CD4+ and CD8+ T cells expressing CCR5 in patients with structural cardiopathy, but normal global ventricular function and no symptoms of chronic heart failure. Even naïve T cells expressed CCR5 in these patients. In contrast, reduced frequencies of CD4+ and CD8+ effector T cells expressing CXCR3 were observed in patients presenting with severe heart disease. Patients with increased left ventricular diameter, heart enlargement, and insufficiency had higher frequencies of CCR5+ effector and effector memory CD8+ T cells. Moreover, the percentage of effector CCR5+ CD8+ T cells was increased in patients with a reduced ejection fraction. Our results show that high expression CCR5 and low expression of CXCR3 on circulating T cells are associated with worse prognosis, possibly reflecting immune‐mediated cardiac remodeling of CCC.

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2 nd Brazilian Consensus on Chagas Disease, 2015

Cited by 278 publications

References 217 publications

Patients with Chagas Disease and Cardiac Arrest Treated at the Emergency Department of a Reference Hospital in Brazil

Patients with Chagas Disease and Cardiac Arrest Treated at the Emergency Department of a Reference Hospital in Brazil

The continuous challenge of Chagas disease treatment: bridging evidence-based guidelines, access to healthcare, and human rights

Increased frequencies of circulating CCR5+ memory T cells are correlated to chronic chagasic cardiomyopathy progression

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