Clinical progression of COVID-19 coinfection in people living with the human immunodeficiency virus: scoping review

Abstract

Objectives: to map the production of scientific knowledge on the clinical progression of COVID-19 coinfection in people living with the human immunodeficiency virus (HIV). Methods: scoping review, with search strategies in MEDLINE, Scopus, Embase, Web of Science, and LILACS. Dual independent data extraction and analysis of the material with similarity compilation and narrative synthesis. Results: sample consisted of 35 articles. Fever, cough, and dyspnea were the most prevalent signs/symptoms. Recurrent complications involved desaturation/worsening of oxygen desaturation and pneumonia. No standard pharmacological treatment was identified, and the main interventions involved the provision of supplemental oxygen and mechanical ventilation. The studies recommended preventive, care, and pharmacological practices. Conclusions: the clinical manifestations, complications, and treatments/assistance care for people coinfected with SARS CoV-2/HIV are similar to those of the general population. Coinfection, overall, does not infer a worse prognosis.

Virtual screening of substances used in the treatment of SARS-CoV-2 infection and analysis of compounds with known action on structurally similar proteins from other viruses

“…The analysis of the crystallographic structure of RdRp shows the distinct shape of the right hand consisting of a palm, fingers, and thumb. [129] , [130] . Involved in genomic transcription and replication, RdRp is considered a valuable therapeutic target ( Fig.…”

Consequences of COVID-19 Among Adult HIV Patients Versus Non-HIV Patients: Two-Year Data From the Primary Isolation Centre in Sudan

“…The impact of the COVID-19 pandemic on a rather significant number of individuals with HIV globally is very challenging for health systems worldwide, as more aggressive preventive and therapeutic measures might be required for this population [12,13]. Therefore, several studies explored the implications, hospitalisation risk, and outcomes attributed to HIV in patients with COVID-19 co-infection; however, results were primarily conflicting [14][15][16][17][18]. Therefore, our study aimed to explore the implications of COVID-19 among HIV patients in contrast to non-HIV patients admitted to the primary isolation centre in Khartoum state, Sudan, over two years to reach concise outcomes based on which guidelines on managing HIV/COVID-19 co-infections can be implemented.…”

Manifestações clínicas da coinfecção entre covid-19 e dengue em adultos: revisão integrativa

“…Dentre os aspectos clínicos da dengue clássica pode-se citar a manifestação de febre alta, cefaleia, mialgia, artralgia, astenia, dor retro orbital, náuseas, vômitos, exantema e prurido cutâneo, que variam de acordo com a idade do paciente, podendo evoluir até para quadros de hemorragia e choque (6) . De forma semelhante, a COVID-19 se caracteriza pela presença de sintomas gerais como febre, tosse, dor de garganta, cefaleia, artralgia, fadiga e dispneia, apresentando aspectos clínicos que variam de quadros assintomáticos até graves com necessidade de suporte ventilatório (7) .…”

“…Contudo, essa atitude pode negligenciar a atenção com outras doenças que potencializam seu agravo clínico como a Dengue, desta maneira há a necessidade de potencializar a investigação clínica por meio de sinais, sintomas e exames que possibilitem predizer a contaminação ou não entre COVID-19 e Dengue e conter consequências para os sistemas de saúde (10) . Estudos que correlacionem as manifestações clínicas entre ambas as doenças ainda são escassos na literatura, o que denota uma importante lacuna do conhecimento científico neste campo de estudo que poderia subsidiar a assistência em saúde (5)(6)(7)(8)(9) . Portanto, ao fomentar conhecimentos sobre as características clínicas da coinfecção entre dengue e COVID-19 com base na produção científica, permite-se ao enfermeiro considerar as características clínicas de ambas as doenças no atendimento inicial ao paciente, favorecendo o encaminhamento direcionado dentro da rede de serviços e a resolutividade do seu problema de saúde ofertando melhores condições de assistência.…”