Virtual screening of substances used in the treatment of SARS-CoV-2 infection and analysis of compounds with known action on structurally similar proteins from other viruses

The landscape of potential health benefits of carotenoids as natural supportive therapeutics in protecting against Coronavirus infection

“…As clinical trials on other carotenoids are limited, well-designed future RCTs are necessary to provide robust evidence on the most appropriate choice of carotenoids to support immune homeostasis and function. To identify and research the efficacy of ACE2 inhibitors, in silico techniques (such as molecular docking and virtual screening) and bibliometric analysis can be efficiently used to discover and systematically screen more carotenoids that has ACEI potentials before further the in vitro and in vivo studies [168] . Further, a range of pharmacokinetics considerations (optimal doses, upper levels of intake, bioavailability and bioaccessibility factors), the duration of administration, characterization of the efficacy of each compound, and possible side effects remain to be determined.…”