Cross-cultural adaptation and validation of the International Cooperative Ataxia Rating Scale (ICARS) to Brazilian Portuguese

Maggi, F.; Braga‐Neto, Pedro; Chien, Hsin Fen; Gama, Maria Thereza Drumond; Filho, Flávio Moura Rezende; Saraiva-Pereira, Maria Luiza; Jardim, Laura Bannach; Voos, Mariana Callil; Pedroso, José Luiz; Barsottini, Orlando Graziani Póvoas

doi:10.1590/0004-282x20180098

Cited by 11 publications

(8 citation statements)

References 24 publications

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“…Limb kinetic functions (items 5 to 8) are rated independently for both sides, and the arithmetic mean of both sides is included in the SARA total score. 23 24 25 26 Both scales were translated and validated into Brazilian versions. 23 24 …”

Section: Methodsmentioning

confidence: 99%

Effect of speech therapy on quality of life in patients with spinocerebelar ataxia type 3

et al. 2022

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Background Individuals with spinocerebellar ataxia type 3 (SCA3) present communication and swallowing disorders, and consequent deterioration in quality of life (QOL). Objective To evaluate the impact of a speech therapy rehabilitation program on the QOL of patients with SCA3. Methods All participants were randomly assigned to two groups, an intervention group receiving speech therapy (STG) and a control group (CG). The International Cooperative Ataxia Rating Scale scores were 32.4 ± 20.2, and the Scale for the Assessment and Rating of Ataxia scores were 11.8 ± 8.0. The intervention consisted of a 12-session speech therapy rehabilitation program with oral, pharyngeal, and laryngeal strengthening exercises—the so-called ATAXIA–Myofunctional Orofacial and Vocal Therapy (A-MOVT). They all were submitted to pre- and postintervention evaluations using the World Health Organization's Quality of Life (WHOQOL-BREF) assessment, as well as the Living with Dysarthria (LwD), Quality of Life in Swallowing Disorders (SWAL-QOL), and Food Assessment Tool (EAT-10). Results The study sample consisted of 48 patients with SCA3 (STG = 25; CG = 23), mean age was 47.1 ± 11.4 years; mean age at symptom onset was 36.9 ± 11.3 years; disease duration was 11.9 ± 13.3 years. After the 3-month intervention, there were significant changes in the QOL in the STG compared with the CG, when assessed by the LwD (179.12 ± 62.55 vs. 129.88 ± 51.42, p < 0.001), SWAL-QOL (869.43 ± 153.63 vs. 911.60 ± 130.90, p = 0.010), and EAT-10 (5.16 ± 7.55 vs. 2.08 ± 3.85, p = 0.018). Conclusions Patients with SCA3 should receive continuous speech therapy as part of the A-MOVT program, because therapy helps to improve difficulty swallowing and dysarthria.

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Section: Methodsmentioning

confidence: 99%

Effect of speech therapy on quality of life in patients with spinocerebelar ataxia type 3

et al. 2022

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“…The International Cooperative Ataxia Rating Scale (ICARS) 17 , 18 comprises 19 items divided in four subscales: posture and gait disturbances, kinetic functions, speech disorders and oculomotor disorders, along with a functional test (Archimedes spiral). The maximum cumulative score is 100 points.…”

Section: Outcome Measures and Clinical Scalesmentioning

confidence: 99%

Rehabilitation in patients with cerebellar ataxias

Chien

Zonta

Chen

et al. 2022

Arq. Neuro-Psiquiatr.

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Cerebellar ataxias comprise a heterogeneous group of diseases characterized by motor and non-motor symptoms, which can be acquired, degenerative, or have a genetic cause, such as spinocerebellar ataxias (SCA). Usually, the genetic and neurodegenerative forms of cerebellar ataxias present a progressive and inevitable worsening of the clinical picture so that rehabilitation treatment is fundamental. Rehabilitation treatment includes physical therapy, respiratory therapy, speech, voice and swallowing therapy, occupational therapy, and new technologies, such as the use of exergames. The current treatment of patients with cerebellar ataxias, especially neurodegenerative forms, genetic or not, should include these different forms of rehabilitation, with the main objective of improving the quality of life of patients.

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“…ICARS has 19 items subdivided into four subscales with a maximum score of 100: posture and gait disturbances; kinetic functions; speech disorders and oculomotor disorders. For the severity classi cation, the following cut-off points were adopted: mild ataxia (1 to 30 points), moderate ataxia (31 to 60 points) and severe ataxia (> 60 points) [35].…”

Section: Neurological Assessmentmentioning

confidence: 99%

Hepatic Fibrosis: A Manifestation of the Evolution of Liver Disease in Patients with Ataxia-Telangiectasia

Barreto

Filho

Shigueoka

et al. 2022

Preprint

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Background: Ataxia-telangiectasia (A-T) is a DNA repair disorder characterized by changes in several organs and systems. Advances in clinical protocols have resulted in increased survival of A-T patients, however disease progression is evident, mainly through metabolic and liver changes. We aimed to identify the frequency of significant hepatic fibrosis in A-T patients and to verify association with metabolic alterations and degree of ataxia. Results: Dyslipidemia was observed in 16/25 (64%), diabetes in 4/22 (18%), insulin resistance in 5/17 (29%), hepatic steatosis in 13/20 (65%) and suggestive of significant hepatic fibrosis in 5/25 (20%). Patients in the group with significant hepatic fibrosis were older (p<0.001), had lower platelet values (p=0.027), albumin (p=0.019), HDL-c (p=0.013) and Matsuda index (p=0.044); and high values of LDL-c (p=0.049), AST (p=0.001), alanine aminotransferase (p=0.002), gamma-glutamyl transferase (p=0.001), ferritin (p=0.001), 120-minutes glycemia by OGTT (p=0.049), HOMA-AD (p=0.016) and degree of ataxia (p=0.009). Conclusions: A suggestive diagnosis of significant hepatic fibrosis was observed in 20% of A-T patients which was associated with changes in liver enzymes, ferritin, increased HOMA-AD and with severity of ataxia compared to patients without hepatic fibrosis.

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Cross-cultural adaptation and validation of the International Cooperative Ataxia Rating Scale (ICARS) to Brazilian Portuguese

Cited by 11 publications

References 24 publications

Effect of speech therapy on quality of life in patients with spinocerebelar ataxia type 3

Effect of speech therapy on quality of life in patients with spinocerebelar ataxia type 3

Rehabilitation in patients with cerebellar ataxias

Hepatic Fibrosis: A Manifestation of the Evolution of Liver Disease in Patients with Ataxia-Telangiectasia

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