Diagnostic Value of Serum Cytokines in Predicting a Complicated Acute Appendicitis

Binboğa, Sinan; Işıksaçan, Nilgün; Binboğa, Elif; Kasapoğlu, Pınar; Sürek, Ahmet; Karabulut, Mehmet

doi:10.1590/0001-3765202220201947

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…IL-10 is recognized as an anti-inflammatory cytokine as it operates through negative feedback on diverse immune responses 36 . The finding that IL-1β was not associated with an increased risk of complicated appendicitis is in accordance with a previous study on adults 16 , but in contrast to the results from a different study that found significantly higher levels of IL-1β in adults with complicated appendicitis 17 . Serum IL-17 has, in a previous study, been found to be elevated in adults with gangrenous appendicitis compared to adults with phlegmonous appendicitis 9 .…”

Section: Discussionsupporting

confidence: 91%

“…Other biomarkers, including a number of Th1/17 associated ILs, have been studied in the context of pediatric appendicitis, but their diagnostic accuracy in distinguishing uncomplicated from complicated cases remains unclear 14 , 15 . Additionally, certain biomarkers have only been investigated in adult cases of appendicitis and have not yet been studied in children 16 , 17 . In addition to elucidating its pathogenesis, a biomarker for complicated appendicitis in children could aid in clinical diagnostics which, in turn, would lead to better resource utility and health outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Associations between Th1-related cytokines and complicated pediatric appendicitis

Elliver,

Salö,

Roth

et al. 2024

Sci Rep

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The pathogenesis of appendicitis is not understood fully, and the diagnosis can be challenging. Previous research has suggested an association between a T helper (Th) 1-dependent immune response and complicated appendicitis. This prospective cohort study aimed to evaluate the association between serum concentrations of the Th1-associated cytokines interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-10, IL-17A and tumor necrosis factor beta (TNF-β) and the risk of complicated appendicitis in children. Appendicitis severity was determined through histopathological examination. A total of 137 children < 15 years with appendicitis were included with a median age of 10 years (IQR 8–12); 86 (63%) were boys, and 58 (42%) had complicated appendicitis. Children with complicated appendicitis had significantly higher concentrations of serum IL-6 and IL-10, and lower of TNF-β. After adjustment for age, symptom duration, and presence of appendicolith in a multivariable logistic regression, a higher concentration of IL-6 remained associated with an increased risk of complicated appendicitis (aOR 1.001 [95% CI 1.000–1.002], p = 0.02). Serum concentrations of IL-1α, IL-1β, IL-2, IL-10, IL-17A and TNF-β were not significantly associated with the risk of complicated appendicitis. In conclusion, our results suggests that the systemic inflammatory response in complicated appendicitis is complex and not solely Th1-dependent.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Associations between Th1-related cytokines and complicated pediatric appendicitis

Elliver,

Salö,

Roth

et al. 2024

Sci Rep

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“…и иммунной (клеточной и гуморальной) систем. Обнаружено их увлечение при кардиохирургических патологиях [4].…”

unclassified

Lipid Destabilizations Are the Pathogenetic Basis of the Method of Predicting the Course of Urgent Abdominal Diseases

Vlasov¹,

Muratova²,

Vlasova³

et al. 2022

СПНО (MPSE)

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Выполнено исследование 144 пациентов с ургентными патологиями живота, разделенных на 3 группы. Первая группа (n=77) -с острым перитонитом, вторая (n=38) -с острой кишечной непроходимостью, третья (n=29) -с панкреонекрозом. Вид лечения -хирургический. Объем оперативной коррекции определялся характером заболевания. Методы исследования: определены параметры процессов липопереокисления, эндотоксикоза, мембранодестабилизирующих явлений. На основе вышеуказанных параметров разработан индекс определения исхода раннего периода после операции (патент № 2729730). Установлено, что в предложенном методе определяются вероятность формирования воспалительных и гнойных процессов с применением не только стандартных параметров (содержание лейкоцитов и токсинов в плазме крови), но и показателей эндотоксикоза (уровня молекулы средней массы), липопереокисления (количества малонового диальдегида), а также их степень выраженности по активности мембранодестабилизирующих явлений (активности лизоформ фосфолипидов). Определение исследованных параметров обладает интегральной количественной характеристикой, а не статической, что позволяет динамично оценить ранний послеоперационный период и быстро и достоверно прогнозировать риск развития осложнений. Расчет индекса прогнозирования течения раннего срока после хирургического лечения апеллируют на абсолютными данными, связанными с многими обстоятельствами, как технические нюансы каждой лаборатории, что в целом позволяет исключить возможность ошибочного прогноза. Ключевые слова: перитонит, панкреатит, кишечная непроходимость, интоксикация, липопериокисление.

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Individual biomarkers in the blood are not yet applicable in diagnosing complicated appendicitis: A scoping review

Sikander

Rosenberg

Fonnes

2023

The American Journal of Emergency Medicine

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Diagnostic Value of Serum Cytokines in Predicting a Complicated Acute Appendicitis

Cited by 3 publications

References 26 publications

Associations between Th1-related cytokines and complicated pediatric appendicitis

Associations between Th1-related cytokines and complicated pediatric appendicitis

Lipid Destabilizations Are the Pathogenetic Basis of the Method of Predicting the Course of Urgent Abdominal Diseases

Individual biomarkers in the blood are not yet applicable in diagnosing complicated appendicitis: A scoping review

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