Individual biomarkers in the blood are not yet applicable in diagnosing complicated appendicitis: A scoping review

Sikander, Binyamin; Rosenberg, Jacob; Fonnes, Siv

doi:10.1016/j.ajem.2023.02.016

Cited by 4 publications

(3 citation statements)

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“…Our results suggested that, although biomarkers appear to be useful in the selection of patients with low suspicion of acute appendicitis, none showed superior diagnostic performance with NPVs above 90%, except for PCT. This fact has been observed in several studies whose main objectives were different from that or had smaller sample size, but supports our initial hypothesis [15–17].…”

supporting

confidence: 91%

Diagnostic performance of serum biomarkers in acute appendicitis in children

Pernía,

Cancho,

Segovia

et al. 2023

European Journal of Emergency Medicine

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supporting

confidence: 91%

Diagnostic performance of serum biomarkers in acute appendicitis in children

Pernía,

Cancho,

Segovia

et al. 2023

European Journal of Emergency Medicine

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“…La principal limitación de esos estudios es la heterogeneidad de las poblaciones estudiadas, que en muchos casos son mixtas (adultos y niños). Otra limitación importante, muy frecuente en los estudios que analizan exclusivamente en poblaciones pediátricas, es el escaso tamaño muestral [46,47].…”

Section: El Rol De Los Biomarcadores Séricos En El Diagnóstico De La ...unclassified

“…La creación de ratios derivados de estos parámetros básicos, como el índice neutrófilo-linfocito, ha mejorado parcialmente el rendimiento diagnóstico de estos marcadores, pero aún dista de ser perfecto. Por otro lado, recientemente se han evaluado biomarcadores novedosos como potenciales herramientas diagnósticas en la apendicitis aguda [46,47], pero la evidencia a este respecto es todavía escasa y la mayoría se limita a series unicéntricas de pequeño tamaño.…”

Section: Justificación Del Trabajounclassified

Valoración de la aplicabilidad clínica y de la rentabilidad diagnóstica de un panel de biomarcadores en sangre periférica en la apendicitis aguda pediátrica

Arredondo¹

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Background Despite the radiological and analytical advances of the last decades, there is still a significant rate of diagnostic error in pediatric acute appendicitis. In recent years, multiple biomarkers have emerged as potential diagnostic tools. This study aimed to examine the diagnostic performance of serum interleukin-6 in pediatric acute appendicitis. Methods We conducted a systematic review of the literature that involved an extensive search in the main databases of medical bibliography (Medline, PubMed, Web of Science and SciELO). Two independent reviewers selected the relevant articles based on the previously defined inclusion and exclusion criteria. Methodological quality of the selected article was rated using the QUADAS2 index. Data extraction was performed by two independent reviewers. ResultsThe research in the medical bibliography databases resulted in 68 articles. We removed 26 duplicates. Among the remaining 42 articles, we excluded 33 following the inclusion and exclusion criteria. Of the final 9 studies included in this review, 8 provided measured serum interleukin-6 values, and all of them reported significant differences between groups, but inconsistent results regarding sensitivity and specificity. Conclusions The diagnostic performance of interleukine-6 alone for the diagnosis of acute appendicitis in children is limited. The sensitivity and specificity of interleukine-6 for the diagnosis of non-complicated acute appendicitis in the pediatric population are moderate but increased in complicated appendicitis. There seems to be a direct relationship between serum level of interleukin-6 and the hours of evolution of abdominal pain in children with acute appendicitis. The increasingly widespread use of non-operative management of acute appendicitis warrants further exploration of the classificatory potential of this marker between complicated and uncomplicated appendicitis. We consider that this may be an avenue of research to explore in the future.

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