Genotoxic and Genoprotective Potential of Black Mulberry (Morus nigra) Fruit

Yılmaz, Serkan; Uçar, Aslı; Göktaş, Bayram

doi:10.1590/0001-3765201920190337

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…to an anti-tumor agent (mitomycin C). Mitomycin C-induced micronucleus frequency and chromosomal aberration decreased due to the fruit juice antioxidant activity (Yilmaz et al, 2019).…”

Section: Ta B L E 2 (Continued)mentioning

confidence: 99%

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Mulberry plant as a source of functional food with therapeutic and nutritional applications: A review

Maqsood

Saeed

Sahar

et al. 2022

Journal of Food Biochemistry

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Medicinal plants from the family Moraceae have diverse applications in agriculture, cosmetics, food, and the pharmaceutical industry. Their extensive spectrum of pharmacological activity for treating numerous inflammatory illnesses, cancer, cardiovascular diseases, and gastrointestinal problems reflects their biological and therapeutic value. This article summarizes the molecular mechanisms related to the biological implications of mulberry extracts, fractions, and isolated bioactive compounds from different parts in various health‐related ailments. Additionally, the food industry and animal nutrition applications are summarized. Phytochemicals such as steroids, saponins, alkaloids, glycosides, polysaccharides, and phenolic compounds including terpenoids, flavonoids, anthocyanins, and tannins are found in this medicinal plant. The aqueous, ethanolic, and methanolic extracts, as well as bioactive compounds, have anti‐oxidative, hypoglycemic, nephroprotective, antimicrobial, neuroprotective, anti‐mutagenic, hepatoprotective, anthelmintic, immune‐modulatory, cardioprotective, and skin protecting activities. Mulberry supplementation in food products improves the stability of phenolics, sensory properties, antioxidant activity, and antimicrobial properties. Mulberry leaves in animal feed increase the nutrient digestibility, growth parameters, antimicrobial, and antioxidant properties. Practical applications This review summarized the in vivo and in vitro biological activities of the mulberry and isolated constituents in various health conditions. In addition, the food uses such as antioxidant potential, antimicrobial, and physicochemical properties were discussed. Furthermore, in vivo studies revealed mulberry as a significant protein source and its flavonoids as potential animal foliage.

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“…to an anti-tumor agent (mitomycin C). Mitomycin C-induced micronucleus frequency and chromosomal aberration decreased due to the fruit juice antioxidant activity (Yilmaz et al, 2019).…”

Section: Ta B L E 2 (Continued)mentioning

confidence: 99%

“…Another in vitro investigation showed genoprotective activity of M. nigra fruit juice against genomic changes in human lymphocytes due to an anti‐tumor agent (mitomycin C). Mitomycin C‐induced micronucleus frequency and chromosomal aberration decreased due to the fruit juice antioxidant activity (Yilmaz et al, 2019).…”

Section: Therapeutic Effectsmentioning

confidence: 99%

Mulberry plant as a source of functional food with therapeutic and nutritional applications: A review

Maqsood

Saeed

Sahar

et al. 2022

Journal of Food Biochemistry

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“…In the literature, toxicological data about chronic use of this plant are limited. Yilmaz and colleagues [79] used cultured human peripheral lymphocytes to study the potential genotoxic effect of M. nigra fruit. Their results demonstrated that the fruit juice had no genotoxic effect but showed protective activity against mitomycin-induced genomic changes.…”

Section: Toxicology Of M Nigramentioning

confidence: 99%

Protective Effects of Morus nigra and Its Phytochemicals against Hepatotoxicity: A Review of Preclinical Studies

Ghorbani

Hooshmand

2021

Pharmacology

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Background: Our liver has a variety of vital functions including removing poisons, storing energy, immunological roles, and secretory and excretory functions. It may face some kinds of diseases caused by viruses, hepatotoxic chemicals, drugs, alcohol, and inherited disorders. Oxidative stress and inflammation are in the core of mechanisms of liver damages induced by viruses or chemical agents. Summary: Morus nigra (M. nigra), generally known as black mulberry, exhibited wide-spectrum pharmacological effects including antidiabetic, antinociceptive, anticancer, and hepatoprotective activities. Different parts of this plant particularly the fruit and leaf have shown beneficial effects on hepatocytes in cell culture and animal models of liver damages induced by chemicals (e.g., CCl4), drugs (e.g., paracetamol), diet (e.g., high fat), diabetes, etc. The beneficial effects of M. nigra on the liver are attributed to the presence of considerable amounts of phenolic compounds such as anthocyanins, flavonols, and phenolic acids. The present review is aimed to focus on the hepatoprotective activities of M. nigra and its phytochemicals and the mechanisms responsible for these activities. Key Messages: The evidence reviewed in this study can help design clinical trials on M. nigra in patients with liver disorders and develop a hepatoprotective herbal medicine.

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“…Anthocyanins, polyphenols, and flavonoids are medicinally active compounds in M. nigra fruit and have various biological activities (Jiang et al, 2017). The fruit exhibits antioxidant (Bao et al, 2019), genoprotective (Yilmaz et al, 2019), antibacterial (Trak & Arslan, 2021), anti‐inflammatory (Shahani et al, 2017), anti‐septic (de Pádua Lúcio et al, 2018), and hepatoprotective (Elmasry & Moawad, 2021) activities. In addition, fruit also has gastroprotective (Nesello et al, 2017), bone protection (Targhi et al, 2017), skin protection (Budiman et al, 2019), anticancer (Erden, 2021), neuroprotective (Suttisansanee et al, 2020), and antidiabetic effects (Budiman et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical characterization ofMorus nigrafruit ultrasound‐assisted ethanolic extract for its cardioprotective potential

Maqsood

Khan

Sharif

et al. 2022

Journal of Food Biochemistry

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The current work investigated the phytochemical profile of ultrasound‐assisted ethanolic extract of Morus nigra (M. nigra) fruit. FTIR analysis of M. nigra fruit extract revealed the presence of alcohols (O‐H), alkanes (C‐H stretch), alkenes (C=C), and alkynes (C≡C). The HPLC analysis quantified the quercetin, gallic acid, vanillic acid, chlorogenic acid, syringic acid, cinnamic acid, sinapic acid, and kaempferol. Furthermore, the cardioprotective activity of ethanolic extract of M. nigra fruit was investigated. Cholesterol supplementation (2%) in the daily diet and exposure to cigarette smoke (2 cigarettes twice a day) were to induce hypertension in rats. The experimental animals were categorized into four groups: G0 (negative control), G1 (positive control), G2 (standard drug), and G3 (M. nigra fruit). The fruit extract administration at 300 mg/kg BW/day orally for 2 months significantly (p < .001) enhanced the activities of serum and cardiac tissue antioxidants in hypertensive rats. Meanwhile, the fruit extract reduced the elevated serum lipid profile while significantly increasing the high‐density lipoproteins in G3 than G1 and G2. The increase in blood pressure, liver transaminases, and serum lactate dehydrogenase also reduced significantly in M. nigra fruit extract‐treated rats. Histopathological findings revealed mild normalization of cardiac myocytes with central nuclei, branching, and cross‐striations. Consequently, the M. nigra fruit extract exerted the cardioprotective potential via increasing the antioxidant enzymes and reducing the lipids, lactate dehydrogenase, liver transaminases, and blood pressure. The therapeutic potential of M. nigra fruit can be due to flavonols and phenolic acids. Practical applications The present work quantified the Morus nigra fruit phytochemicals and its significant role in reducing lipid markers and blood pressure and improving antioxidant status in rats fed a hypercholesterolemic diet and exposed to cigarette smoke. Conclusively, the inclusion of M. nigra fruit in daily diet could improve the cardiac health of the individuals. Furthermore, the therapeutic potential of M. nigra fruit and its isolated constituents in modulating the gene expression against cardiac problems can explore after clinical trials and standardization in higher animals.

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Genotoxic and Genoprotective Potential of Black Mulberry (Morus nigra) Fruit

Cited by 4 publications

References 34 publications

Mulberry plant as a source of functional food with therapeutic and nutritional applications: A review

Mulberry plant as a source of functional food with therapeutic and nutritional applications: A review

Protective Effects of <b><i>Morus nigra</i></b> and Its Phytochemicals against Hepatotoxicity: A Review of Preclinical Studies

Phytochemical characterization ofMorus nigrafruit ultrasound‐assisted ethanolic extract for its cardioprotective potential

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