Protective Effects of &lt;b&gt;&lt;i&gt;Morus nigra&lt;/i&gt;&lt;/b&gt; and Its Phytochemicals against Hepatotoxicity: A Review of Preclinical Studies

Ghorbani, Ahmad; Hooshmand, Sara

doi:10.1159/000515032

Cited by 12 publications

(9 citation statements)

References 75 publications

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“…Phytochemicals derived from plants, such as flavonoids, terpenoids, phenolics, alkaloids, and other compounds, are recognized for their potential to confer numerous benefits to the body, particularly in supporting liver function. [19][20] Key effects include minimizing liver damage, detoxification, and safeguarding the liver against harmful agents. Within black shallot extract, the presence of polyphenols and flavonoids allows for intricate interactions with other phytochemicals, creating a synergistic collaboration.…”

Section: Resultsmentioning

confidence: 99%

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Counteracting Paracetamol-Induced Hepatotoxicity with Black Shallot Extract: An Animal Model Investigation

2024

TJNPR

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Excessive paracetamol consumption leads to the formation of a dangerous compound called "N-acetyl-p-benzoquinone-imine" (NAPQI) through the enzymatic metabolic pathway. NAPQI depletes the liver's limited glutathione reserves, resulting in irreversible binding to liver cells, which can lead to hepatotoxicity and potential liver necrosis. 5 Public apprehension surrounding paracetamol-induced liver toxicity has spurred extensive research aimed at uncovering its mechanisms. Oxidative stress has been closely linked to paracetamol's toxic effects. 3 N-acetyl cysteine (NAC), a well-known antioxidant, is commonly used to mitigate paracetamol-induced liver toxicity. NAC protects the liver by preventing the depletion of cellular glutathione (GSH), thus inhibiting oxidative reactions within the cells. However, NAC treatment can lead to adverse effects, and its efficacy diminishes if administered more than 8 hours after paracetamol overdose. Therefore, there is a pressing need to investigate alternative or adjunct therapeutic agents, particularly those derived from traditional botanical sources known for their historical contributions to medicine. 2 Shallot (Allium ascalonicum Linn.), a member of the Liliaceae family, has a rich history in traditional cuisine. It offers antibacterial, antifungal, and antioxidant properties, along with the ability to neutralize peroxynitrite. 6 Shallots contain essential proteins, dietary fiber, minerals, and vitamins (A, B, C), as well as phenolic and flavonoid compounds like gallic acid, apigenin, quercetin, and tannic acid, which confer antioxidant benefits for liver and kidney health. 7 Additionally, shallots exhibit anti-cancer properties, inhibiting the growth of cancer cell lines, including HeLa and MCF-7, and promoting apoptosis in cervical cancer cells. 6 Innovative techniques have transformed pungent purple shallots into sweet black shallots rich in bioactive compounds like quercetin and branched-chain amino acids. These components offer antioxidative, anti-inflammatory, anti-cancer, and liver and kidney detoxification benefits. 7 Despite research on black shallot's potential, its effectiveness in addressing paracetamol-induced liver toxicity remains

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Section: Resultsmentioning

confidence: 99%

“…The combination of these compounds not only targets the liver but also contributes to overall health benefits for the body. 19 Consequently, black shallot extract not only provides essential phytochemicals but also stimulates positive interactions among them, effectively protecting the liver and sustaining its functionality.…”

Section: Resultsmentioning

confidence: 99%

Counteracting Paracetamol-Induced Hepatotoxicity with Black Shallot Extract: An Animal Model Investigation

2024

TJNPR

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“…Blackberry phenolic compounds have demonstrated the capacity to diminish LDL oxidation, quench free radicals by hydrogen molecule donation, and interfere with liposome oxidation systems [165,166]. In particular, anthocyanins from M. nigra showed the capacity to protect human primary endothelial cells by decreasing the production of the cytokine-induced chemokine monocyte chemotactic protein 1, a protein directly linked to atherogenesis, and which is mainly responsible for attracting macrophages to sites of infection or inflammation [167].…”

Section: Cardiovascular Protectionmentioning

confidence: 99%

“…In epidemiological studies, diets high in plant-derived phenolic compounds have been shown to reduce the incidence of coronary heart disease. The chronic antioxidant and hypolipidemic characteristics of these compounds play critical roles in the prevention of lipoprotein oxidation and the formation of atherosclerotic lesions [2,122,166,169].…”

Section: Cardiovascular Protectionmentioning

confidence: 99%

Blackberries and Mulberries: Berries with Significant Health-Promoting Properties

Martins

Gonçalves

Meirinho

et al. 2023

IJMS

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Blackberries and mulberries are small and perishable fruits that provide significant health benefits when consumed. In reality, both are rich in phytochemicals, such as phenolics and volatile compounds, and micronutrients, such as vitamins. All the compounds are well-known thanks to their medicinal and pharmacological properties, namely antioxidant, anti-inflammatory, anti-cancer, antiviral, and cardiovascular properties. Nevertheless, variables such as genotype, production conditions, fruit ripening stage, harvesting time, post-harvest storage, and climate conditions influence their nutritional composition and economic value. Given these facts, the current review focuses on the nutritional and chemical composition, as well as the health benefits, of two blackberry species (Rubus fruticosus L., and Rubus ulmifolius Schott) and one mulberry species (Morus nigra L.).

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“…Many research studies reported the phytochemical and pharmacological aspects of M. nigra as an antidiabetic drug [103,113,141] and found that all botanical parts (leaves, root, branches and fruits) have special effects on antidiabetic activity [26,72,113,142].…”

Section: Antidiabetic Therapymentioning

confidence: 99%

Phytochemical Composition of Different Botanical Parts of Morus Species, Health Benefits and Application in Food Industry

Memete

Timar

Vuşcan

et al. 2022

Plants

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In recent years, mulberry has acquired a special importance due to its phytochemical composition and its beneficial effects on human health, including antioxidant, anticancer, antidiabetic and immunomodulatory effects. Botanical parts of Morus sp. (fruits, leaves, twigs, roots) are considered a rich source of secondary metabolites. The aim of our study was to highlight the phytochemical profile of each of the botanical parts of Morus tree, their health benefits and applications in food industry with an updated review of literature. Black and white mulberries are characterized in terms of predominant phenolic compounds in correlation with their medical applications. In addition to anthocyanins (mainly cyanidin-3-O-glucoside), black mulberry fruits also contain flavonols and phenolic acids. The leaves are a rich source of flavonols, including quercetin and kaempferol in the glycosylated forms and chlorogenic acid as predominant phenolic acids. Mulberry bark roots and twigs are a source of prenylated flavonoids, predominantly morusin. In this context, the exploitation of mulberry in food industry is reviewed in this paper, in terms of developing novel, functional food with multiple health-promoting effects.

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Protective Effects of <b><i>Morus nigra</i></b> and Its Phytochemicals against Hepatotoxicity: A Review of Preclinical Studies

Cited by 12 publications

References 75 publications

Counteracting Paracetamol-Induced Hepatotoxicity with Black Shallot Extract: An Animal Model Investigation

Counteracting Paracetamol-Induced Hepatotoxicity with Black Shallot Extract: An Animal Model Investigation

Blackberries and Mulberries: Berries with Significant Health-Promoting Properties

Phytochemical Composition of Different Botanical Parts of Morus Species, Health Benefits and Application in Food Industry

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