Regular exercise, overweight/obesity and sedentary lifestyle cause adaptive changes in thiol–disulfide homeostasis

Göl, Mehmet Fatih; Özkaya, Beytullah; Yıldırım, Caner; Bal, Ramazan

doi:10.1590/0001-3765201920180547

Cited by 8 publications

(9 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another limitation is that measurements were not performed at the end of a long period of detoxification. Life style, exercise, and obesity have also been reported to affect TDH homeostasis [34]. In our study, although the BMI of the patient and control groups were similar, their life style and duration of exercise were not questioned.…”

Section: Discussionmentioning

confidence: 52%

Methamphetamine’s effects on oxidative stress markers may continue after detoxification: a case–control study

Hacımusalar

Karaaslan

Bal

et al. 2019

Psychiatry and Clinical Psychopharmacology

View full text Add to dashboard Cite

OBJECTIVE: Substance use disorder (SUD) is a critical public health problem. The use of methamphetamine is increasing daily worldwide. The aetiology of SUD is related to numerous factors that have not been fully elucidated. It is known that there are some changes in oxidative stress in substance use disorder. However, to the best of our knowledge, there is no study showing changes in thiol/disulphide homeostasis (TDH) in methamphetamine use disorder (MUD). METHODS: Forty-four male patients with MUD and forty-five healthy male controls were included in the study. Only patients who had used methamphetamine in the last three months were included. Blood samples were taken from the patients one day after hospitalization and after detoxification for measurement of the thiol/disulphide level. RESULTS: The levels of native thiol, total thiol, and disulphide in the MUD group were significantly higher than in the control group. At the end of the detoxification period, the levels of native thiol and total thiol did not change significantly, but an increase in the disulphide level was observed. CONCLUSION: The results of our study show that there was a shift in the disulphide direction in the TDH, which is an indicator of oxidative stress in the patient group, and this shift continued after the detoxification period of between 5 and 21 days. There is no other study in the literature evaluating TDH in patients with MUD. Therefore, our study is important for clarifying the aetiopathogenesis of SUD.

show abstract

Section: Discussionmentioning

confidence: 52%

Methamphetamine’s effects on oxidative stress markers may continue after detoxification: a case–control study

Hacımusalar

Karaaslan

Bal

et al. 2019

Psychiatry and Clinical Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…There was no significant difference between these groups in the native thiol groups. In terms of the total number of thiol groups, the highest value was found among people who exercise regularly and the lowest among people who lead a sedentary lifestyle [ 34 ]. In our study, we assessed the concentration of thiol groups per gram of protein.…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative Medicine and Cellular Longevity lowest among people who lead a sedentary lifestyle [34]. In our study, we assessed the concentration of thiol groups per gram of protein.…”

mentioning

confidence: 99%

Oxidative Stress in Association with Metabolic Health and Obesity in Young Adults

Jakubiak

Osadnik

Lejawa

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Introduction. Obesity is one of the most important public health problems in the world. Among obese people, there are those who, apart from excessive body weight, do not exhibit other metabolic dysfunctions, have a lower risk of developing cardiovascular diseases (CVDs), and show lower mortality. According to the theory, they are referred as metabolically healthy obese (MHO), in contrast to metabolically unhealthy obese (MUO). Metabolic disturbances occurring with obesity have been well established to be associated with oxidative stress. Aim. The purpose of this study was to analyse the association between selected anthropometric and biochemical parameters with oxidative stress in MHO, MUO, and normal weight young adults. Material and Methods. Individuals with age between 18 and 36 years with no history of chronic diseases and use of medicaments, with or without obesity, participated in the study. Complete blood counts, biochemical measurements, and parameters of oxidative stress such as total antioxidant capacity (TAC), total oxidative status (TOS), oxidative stress index (OSI), serum concentration of malondialdehyde (MDA), ceruloplasmin, thiol groups and lipid hydroperoxides (LPH), concentration of lipofuscin (LPS) in erythrocytes, and the activity of superoxide dismutase (SOD) were measured. Results. 422 patients who met the inclusion criteria were enrolled in the study. Among the study participants, 208 people (49.29%) were offspring of patients with angiographically confirmed coronary artery disease. Among the participants, 16 patients have been included in the group of metabolically healthy obese (MHO) people and 61 patients in the group of metabolically unhealthy obese (MUO) people and 345 patients had normal body weight. Significant differences between metabolically unhealthy obese and normal weight patients, as well as between women and men, have been found. Conclusions. We showed significant differences in the selected parameters of oxidative stress between metabolically unhealthy obese (MUO) individuals and young volunteers with normal body weight as well as without significant medical history.

show abstract

“…Albumin is one of the protein thiols that is abundant in plasma ( Kundi et al, 2015 ). Gol et al (2019) indicated that the total thiol pool that stands for antioxidant capacity is of insufficient function in sedentary people. Thus, in conditions associated with increasing oxidative stress, stimulation of the antioxidant defense and protein thiols may be not sufficiently effective in subjects with sedentary lifestyle ( Gol et al, 2019 ; Tebay et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Qigong exercise on muscle strengths and oxidative stress/antioxidant responses in young sedentary females: a quasi-experimental study

Klarod¹,

Singsanan²,

Thamwiriyasati³

et al. 2020

J Exerc Rehabil

View full text Add to dashboard Cite

Regular exercise is associated with the production of small amounts of oxidative stress which might promote individual antioxidant capacity contributing to favorable training effects potentially interrelated with skeletal muscle strength. Therefore, the present study was aimed at evaluating effects of an 8-week Qigong exercise training on muscle strengths associated with responses of oxidative stress and antioxidants in young sedentary females. A total of 41 sedentary women were allocated to the Qigong exercise group (QG, N= 20) or to the control group (CG, N= 21). After 8 weeks of Qigong training, back and leg strength was significantly improved compared to baseline and the CG (P< 0.05). Plasma oxidative stress levels were reduced and total antioxidant capacity was enhanced in the QG compared to the CG (P< 0.05). Correlation analyses revealed that improvements in muscle strength (including both groups) were associated with changes in the levels of oxidative stress (reduction) and antioxidants (elevation). The presented findings indicate that strength training effects seem at least partly to be interrelated with alterations of the oxidant-antioxidant balance generated by the 8-week Qigong training in young sedentary females.

show abstract

Regular exercise, overweight/obesity and sedentary lifestyle cause adaptive changes in thiol–disulfide homeostasis

Cited by 8 publications

References 33 publications

Methamphetamine’s effects on oxidative stress markers may continue after detoxification: a case–control study

Methamphetamine’s effects on oxidative stress markers may continue after detoxification: a case–control study

Oxidative Stress in Association with Metabolic Health and Obesity in Young Adults

Effects of Qigong exercise on muscle strengths and oxidative stress/antioxidant responses in young sedentary females: a quasi-experimental study

Contact Info

Product

Resources

About