Methamphetamine’s effects on oxidative stress markers may continue after detoxification: a case–control study

Hacımusalar, Yunus; Karaaslan, Özgül; Bal, Ceylan; Koçer, Derya; Gök, Gamze; Yildiz, Bayram

doi:10.1080/24750573.2019.1652414

Cited by 7 publications

(9 citation statements)

References 30 publications

(27 reference statements)

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“…These findings extend previous findings that MA use increases MDA and other markers of lipid peroxidation in the blood and brain and decreases catalase, Gpx, GSH, SOD, and thiols groups [ 56 , 57 , 58 , 59 , 60 , 61 ]. MA also causes mitochondrial oxidative damage in human T lymphocytes [ 62 ] and in vivo and in vitro MA exposure increases ROS production in the central nervous system (CNS) [ 63 , 64 ].…”

Section: Discussionsupporting

confidence: 89%

Increased Lipid Peroxidation and Lowered Antioxidant Defenses Predict Methamphetamine Induced Psychosis

Al‐Hakeim

Altufaili

Almulla

et al. 2022

Cells

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Background: a significant percentage of methamphetamine (MA) dependent patients develop psychosis. The associations between oxidative pathways and MA-induced psychosis (MIP) are not well delineated. Objective: the aim of this study is to delineate whether acute MA intoxication in MA dependent patients is accompanied by increased nitro-oxidative stress and whether the latter is associated with MIP. Method: we recruited 30 healthy younger males and 60 acutely intoxicated males with MA dependence and assessed severity of MA use and dependence and psychotic symptoms during intoxication, and serum oxidative toxicity (OSTOX) biomarkers including oxidized high (oxHDL) and low (oxLDL)-density lipoprotein, myeloperoxidase (MPO), malondialdehyde (MDA), and nitric oxide (NO), and antioxidant defenses (ANTIOX) including HDL-cholesterol, zinc, glutathione peroxidase (GPx), total antioxidant capacity (TAC), and catalase-1. Results: a large part (50%, n = 30) of patients with MA dependence could be allocated to a cluster characterized by high psychosis ratings including delusions, suspiciousness, conceptual disorganization and difficulties abstract thinking and an increased OSTOX/ANTIOX ratio. Partial Least Squares analysis showed that 29.9% of the variance in MIP severity (a first factor extracted from psychosis, hostility, excitation, mannerism, and formal thought disorder scores) was explained by HDL, TAC and zinc (all inversely) and oxLDL (positively). MA dependence and dosing explained together 44.7% of the variance in the OSTOX/ANTIOX ratio. Conclusions: MA dependence and intoxication are associated with increased oxidative stress and lowered antioxidant defenses, both of which increase risk of MIP during acute intoxication. MA dependence is accompanied by increased atherogenicity due to lowered HDL and increased oxLDL and oxHDL.

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“…These findings extend previous findings that MA use increases MDA and other markers of lipid peroxidation in the blood and brain and decreases catalase, Gpx, GSH, SOD, and thiols groups [ 56 , 57 , 58 , 59 , 60 , 61 ]. MA also causes mitochondrial oxidative damage in human T lymphocytes [ 62 ] and in vivo and in vitro MA exposure increases ROS production in the central nervous system (CNS) [ 63 , 64 ].…”

Section: Discussionsupporting

confidence: 89%

Increased Lipid Peroxidation and Lowered Antioxidant Defenses Predict Methamphetamine Induced Psychosis

Al‐Hakeim

Altufaili

Almulla

et al. 2022

Cells

View full text Add to dashboard Cite

show abstract

“…These findings extend previous findings that MA use increases MDA and other markers of lipid peroxidation in the blood and brain and decreases catalase, Gpx, GSH, SOD, and thiols groups (Mirecki, Fitzmaurice et al 2004, Moszczynska, Fitzmaurice et al 2004, Fitzmaurice, Tong et al 2006, Govitrapong, Boontem et al 2010, Suriyaprom, Tanateerabunjong et al 2011, Huang, Lin et al 2013, Hacimusalar, Karaaslan et al 2019). MA also causes mitochondrial oxidative damage in human T lymphocytes (Potula, Hawkins et al 2010) and in vivo and in vitro MA exposure increases ROS production in the CNS (Pubill, Chipana et al 2005, Wu, Ping et al 2007).…”

Section: Discussionsupporting

confidence: 89%

Increased lipid peroxidation and lowered antioxidant defenses predict methamphetamine induced psychosis

Al‐Hakeim

Altufaili

Almulla

et al. 2022

Preprint

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Background: A significant percentage of methamphetamine (MA) dependent patients develop psychosis. However, the associations between oxidative pathways and MA-induced psychosis (MIP) are not well delineated. Objective: The aim of this study is to delineate whether acute MA intoxication in MA dependent patients is accompanied by increased nitro-oxidative stress and whether the latter is associated with MIP. Method: We recruited 30 healthy males and 60 acutely intoxicated MA males with MA dependence and assessed severity of MA use and dependence and psychotic symptoms during intoxication and measured serum oxidative toxicity (OSTOX) biomarkers including oxidized high (oxHDL) and low (oxLDL)-density lipoprotein, myeloperoxidase (MPO), malondialdehyde (MDA), and nitric oxide (NO), and antioxidant defenses (ANTIOX) including HDL-cholesterol, zinc, glutathione peroxidase (GPx), total antioxidant capacity (TAC), and catalase-1. Results: A large part (50%, n=30) of patients with MA dependence could be allocated to a cluster characterized by high psychosis ratings including delusions, suspiciousness, conceptual disorganization and difficulties abstract thinking and an increased OSTOX/ANTIOX ratio. Partial Least Squares analysis showed that 29.9% of the variance in MIP severity (a first factor extracted from psychosis, hostility, excitation, mannerism, and formal thought disorder scores) was explained by HDL, TAC and zinc (all inversely) and oxLDL (positively). MA dependence and dosing explained together 44.7% of the variance in the OSTOX/ANTIOX ratio.

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“…There is only one retrospective case-control study in the literature evaluating the oxidative stress status with TDH in patients with MUD [ 26 ]. In this study by Hacimusalar et al .…”

Section: Discussionmentioning

confidence: 99%

“…[ 26 ], the levels of native thiol, total thiol, and disulfide in the patient group with MUD were detected to be significantly higher than in the CG. Besides, only the serum disulfide level continued to increase in the samples taken before and after detoxification [ 26 ]. In our study, serum disulfide levels were observed not to change before detoxification.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress and Inflammatory Biomarkers in People with Methamphetamine Use Disorder

Turan

Şenormancı

Neşeli̇oğlu

et al. 2023

Clin Psychopharmacol Neurosci

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Objective This study aimed to investigate the blood serum levels of biomarkers specifying oxidative stress status and systemic inflammation between people using methamphetamine (METH) and the control group (CG). Serum thiol/disulfide balance and ischemia-modified albumin levels were studied to determine oxidative stress, and serum interleukin-6 (IL-6) levels and complete blood count (CBC) were to assess inflammation. Methods Fifty patients with METH use disorder (MUD) and 36 CG participants were included in the study. Two tubes of venous blood samples were taken to measure oxidative stress, serum thiol/disulfide balance, ischemia-modified albumin, and IL-6 levels between groups. The correlation of parameters measuring oxidative stress and inflammation between groups with sociodemographic data was investigated. Results In this study, serum total thiol, free thiol levels, disulfide/native thiol percentage ratios, and serum ischemia-modified albumin levels of the patients were statistically significantly higher than the healthy controls. No difference was observed between the groups in serum disulfide levels and serum IL-6 levels. Considering the regression analysis, only the duration of substance use was a statistically significant factor in explaining serum IL-6 levels. The parameters showing inflammation in the CBC were significantly higher in the patients than in the CG. Conclusion CBC can be used to evaluate systemic inflammation in patients with MUD. Parameters measuring thiol/disulfide homeostasis and ischemia-modified albumin can be, also, used to assess oxidative stress.

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Methamphetamine’s effects on oxidative stress markers may continue after detoxification: a case–control study

Cited by 7 publications

References 30 publications

Increased Lipid Peroxidation and Lowered Antioxidant Defenses Predict Methamphetamine Induced Psychosis

Increased Lipid Peroxidation and Lowered Antioxidant Defenses Predict Methamphetamine Induced Psychosis

Increased lipid peroxidation and lowered antioxidant defenses predict methamphetamine induced psychosis

Oxidative Stress and Inflammatory Biomarkers in People with Methamphetamine Use Disorder

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