Maternal Exposure to Alcohol and Low Birthweight: A Systematic Review and Meta-Analysis

Pereira, Priscilla Perez da Silva; Mata, Fabiana Araújo Figueiredo Da; Figueiredo, Ana Cláudia Morais Godoy; Silva, Roberta Borges; Pereira, Maúrício Gomes

doi:10.1055/s-0039-1688905

Cited by 8 publications

(4 citation statements)

References 58 publications

(86 reference statements)

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“…Preventive strategies were divided into the 10 following categories: midwifery care, health promotion programs for smoking cessation, alcohol reduction during pregnancy, folic acid, vitamin D, iron, and zinc supplementation, a well-balanced diet, COVID-19 vaccination and cannabis use during pregnancy. The most significant and high-quality publications focusing on preventive strategies [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ] are summarized in Table 1 .…”

Section: Methodsmentioning

confidence: 99%

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Insights into Prevention of Health Complications in Small for Gestational Age (SGA) Births in Relation to Maternal Characteristics: A Narrative Review

Wołejszo

Genowska

Motkowski

et al. 2023

JCM

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Small for gestational age (SGA) births are a significant clinical and public health issue. The objective of this review was to summarize maternal biological and socio-demographic factors and preventive strategies used to reduce the risk of SGA births. A literature search encompassing data from the last 15 years was conducted using electronic databases MEDLINE/PubMed, Google Scholar and Scopus to review risk factors and preventive strategies for SGA. Current evidence shows that primiparity, previous stillbirths, maternal age ≤24 and ≥35 years, single motherhood, low socio-economic status, smoking and cannabis use during pregnancy confer a significant risk of SGA births. Studies on alcohol consumption during pregnancy and SGA birth weight are inconclusive. Beneficial and preventive factors include the “Mediterranean diet” and dietary intake of vegetables. Periconceptional folic acid supplementation, maternal 25-hydroxyvitamin D, zinc and iron levels are partly associated with birth weight. No significant associations between COVID-19 vaccinations and birthweight are reported. A midwifery-led model based on early and extensive prenatal care reduces the risk of SGA births in women with low socio-economic status. Major preventive measures relate to the awareness of modifiable and non-modifiable risk factors of SGA, leading to changes in parents’ lifestyles. These data support that education, monitoring during pregnancy, and implementing preventive strategies are as important as biological determinants in risk reduction of SGA births.

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Section: Methodsmentioning

confidence: 99%

“…In retrospective cohort studies Pereira et al found that an alcohol intake during pregnancy appears to be associated with a lower birth weight. However, in prospective cohort studies and case-control studies the association between maternal exposure to alcohol and birth weight was not observed [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

Insights into Prevention of Health Complications in Small for Gestational Age (SGA) Births in Relation to Maternal Characteristics: A Narrative Review

Wołejszo

Genowska

Motkowski

et al. 2023

JCM

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“…29 Penting untuk diingat bahwa data terkait variabel perilaku merokok dan konsumsi alkohol bersifat subjektif dan berkaitan dengan keterbukaan individu. 30…”

Section: Original Articleunclassified

Faktor risiko kejadian berat bayi lahir rendah di RSUP Sanglah, Denpasar, Bali, Indonesia

Aryana¹,

Sari²,

Aryani³

2021

Intisari Sains Medis

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Introduction:Maternal and child health has become a primary health focus in Indonesia and the maternal and child mortality rate in Indonesia is higher than those in South-East Asia countries. The incidence of Low Birth Weight (LBW) contributes to more than 50% of all neonatal mortality of all births in Indonesia. Therefore, identification of the risk factors that contributes to the incidence of LBW is important. Method: This retrospective case-control study involved 50 cases of LBW and 50 controls (baby with normal birth-weight), The data were analyzed using SPSS version 22. Result: The results of multivariate analysis showed that Pendahuluan: Kesehatan ibu dan anak merupakan salah satu fokus utama kesehatan di Indonesia. Kasus kematian ibu dan anak di Indonesia lebih tinggi dibandingkan dengan negara-negara di Asia Tenggara. Kejadian bayi berat lahir rendah (BBLR) berkontribusi terhadap lebih dari 50% total kematian neonatal di seluruh kelahiran di Indonesia. Oleh karena itu, identifikasi faktor-faktor risiko yang mendasari kejadian BBLR menjadi penting untuk dilakukan. Metode: Penelitian kasus kontrol retrospektif ini melibatkan 50 kasus (BBLR) dan 50 kontrol (bayi lahir dengan berat badan normal. Data yang diperoleh kemudian dianalisis menggunakan perangkat SPSS versi 22. Hasil: Hasil analisis multivariat didapatkan faktor-the factors significantly associated with LBW incidence were maternal blood pressure (p=0.000), history of giving birth to LBW babies (p=0.000), and the mode of current labor (p=0.034). The maternal age, maternal education level, maternal occupation, maternal anemia, parity, history of smoking, history of alcohol consumption, history of abortion, parity distance, and maternal BMI had no significant association (p>0.005). Conclusion: Thus, the incidence of LBW can be prevented through maternal blood control during the pregnancy. Careful history taking of past history of giving birth to LBW babies and the mode of delivery must be done to reduce the incidence of LBW.faktor yang memiliki hubungan signifikan dengan kejadian BBLR adalah tekanan darah ibu (p=0,000), riwayat melahirkan bayi BBLR (p=0,000), dan tipe persalinan bayi saat ini (p=0,034). Sebaliknya, faktor usia ibu, tingkat pendidikan ibu, pekerjaan ibu, anemia pada ibu, jumlah paritas, riwayat merokok, riwayat konsumsi alkohol, riwayat abortus, jarak paritas, dan IMT ibu tidak memiliki hubungan yang signifikan (p>0,005). Simpulan: Pencegahan kejadian BBLR dapat dilakukan dengan mengontrol tekanan darah ibu selama kehamilan. Penggalian riwayat melahirkan bayi BBLR sebelumnya dan pemilihan metode persalinan juga harus dilakukan dengan seksama untuk mengurangi kejadian BBLR.

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“…According to different studies, nobody knows the exact amount of alcohol that is potentially harmful to the developing baby in any trimester. Hence, researchers and health professionals recommend not drinking any amount of alcohol for pregnant women as well as women who are trying to get pregnant [16][17][18][19][20][21][22][23]. The consequences and safety of low-to-moderate alcohol consumption during pregnancy on the fetus is still inconclusive and discordant [9,15,24,25].It is argued that the lack of agreement between studies might be due to heterogeneity of the study participants, methodological differences, low statistical power, potential confounding factors, and the difference in detecting tools used or biased information on maternal alcohol consumption [23,26].…”

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confidence: 99%

The effects of maternal alcohol consumption during pregnancy on adverse fetal outcomes among pregnant women attending antenatal care at public health facilities in Gondar town, Northwest Ethiopia: a prospective cohort study

Addila

Azale

Gete

et al. 2021

Subst Abuse Treat Prev Policy

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Background The teratogenic effect of fetal alcohol exposure may lead to actual and potential problems, instantly after birth, at infancy; or even later, and mental impairment in life. This study aimed to investigate the effects of maternal alcohol consumption during pregnancy on adverse fetal outcomes at Gondar town public health facilities, Northwest Ethiopia. Methods A facility-based prospective cohort study was performed among 1778 pregnant women who were booked for antenatal care in selected public health facilities from 29 October 2019 to 7 May 2020 in Gondar town. We used a two-stage random sampling technique to recruit and include participants in the cohort. Data were collected using the Alcohol Use Disorders Identification Test – Consumption (AUDIT-C) standardized and pre-tested questionnaire. Multivariable analysis was performed to examine the association between reported prenatal alcohol exposure (non-hazardous and hazardous) and interested adverse birth outcomes using log-binomial regression modeling. The burden of outcomes was reported using the adjusted risk ratio and population-attributable risk (PAR). Results A total of 1686 pregnant women were included in the analysis, which revealed that the incidences of low birth weight, preterm, and stillbirth were 12.63% (95% CI: 11.12, 14.31), 6.05% (95% CI: 5.00, 7.29) and 4.27% (95% CI: 3.4, 5.35), respectively. Non-hazardous and hazardous alcohol consumption during pregnancy was significantly associated with low birth weight (ARR = 1.50; 95% CI: 1.31, 1.98) and (ARR = 2.34; 95% CI: 1.66, 3.30), respectively. Hazardous alcohol consumption during pregnancy was also significantly associated with preterm birth (ARR = 2.06; 95% CI: 1.21, 3.52). The adjusted PAR of low birth weight related to non-hazardous and hazardous alcohol drinking during pregnancy was 11.72 and 8.44%, respectively. The adjusted PAR of hazardous alcohol consumption was 6.80% for preterm. Conclusions Our findings suggest that there is an increasing risk of adverse birth outcomes, particularly preterm delivery and low birth weight, with increasing levels of alcohol intake. This result showed that the prevention of maternal alcohol use during pregnancy has the potential to reduce low birth weight and preterm birth. Hence, screening women for alcohol use during antenatal care visits and providing advice with rigorous follow-up of women who used alcohol may save the fetus from the potential risks of adverse birth outcomes.

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Maternal Exposure to Alcohol and Low Birthweight: A Systematic Review and Meta-Analysis

Cited by 8 publications

References 58 publications

Insights into Prevention of Health Complications in Small for Gestational Age (SGA) Births in Relation to Maternal Characteristics: A Narrative Review

Insights into Prevention of Health Complications in Small for Gestational Age (SGA) Births in Relation to Maternal Characteristics: A Narrative Review

Faktor risiko kejadian berat bayi lahir rendah di RSUP Sanglah, Denpasar, Bali, Indonesia

The effects of maternal alcohol consumption during pregnancy on adverse fetal outcomes among pregnant women attending antenatal care at public health facilities in Gondar town, Northwest Ethiopia: a prospective cohort study

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