Comparison of 1α-25-dihydroxyvitamin D3 and IgE Levels between Allergic Rhinitis Patients and Healthy People

Demir, Mehmet Gökhan

doi:10.1055/s-0038-1649492

Cited by 6 publications

(8 citation statements)

References 20 publications

(21 reference statements)

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“…In this study, the mean serum IgE level in moderate-severe AR patients was 383.69±154.86 IU/mL. This is comparable to a study conducted in Turkey in 2018 by Mehmet Gokhan Demir, which included 256 patients and reported levels of 453.6±15.3 IU/ml in patients [18]. Our study findings are also comparable to the study of Osisi K et al conducted in Nigeria in 2017, which revealed a statistically significant difference in serum IgE levels in the AR and normal population (252±60 IU/ml in patients and 106±117.95 IU/ml in healthy population) [19].…”

Section: Discussionsupporting

confidence: 80%

Association of Serum Vitamin D and Immunoglobulin E Levels With Severity of Allergic Rhinitis

Awan¹,

Sohail²,

Naumeri³

et al. 2021

Cureus

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Objective The aim of this study was to determine the association of serum vitamin D and immunoglobulin E (IgE) levels with the severity of allergic rhinitis (AR). Methods This case-control study was conducted at Mayo Hospital, Lahore, from June to September 2020 after obtaining ethical approval. Patients of AR were included and divided with the help of allergic rhinitis and its impact on asthma (ARIA) classification, into group A (cases), patients presenting with moderate to severe symptoms, and into group B (control), patients with mild symptoms, after treatment of AR. The mean difference between serum IgE and serum Vitamin D levels of both groups were compared by t-test. Association was determined by logistic regression and odds ratio. Results A total of 224 patients were included in the study, 112 patients in group A and 112 patients in group B. There were 106 (47.3%) female and 118 (52.7%) male. The mean age of patients in group A was 26.78± 8.92 years and in group B, it was 25.72±8.12 years. Mean serum vitamin D levels in group A were 16.24±6.7 ng/ml and in group B 26.92±35 ng/ml (p=0.0001). Mean serum IgE levels in group A were 383.69±154.86 IU/ml and in group B, they were 373.03±106.83 IU/ml (p=0.0001). Vitamin D deficient patients were 24 times more likely to develop moderate to severe AR disease. Conclusion This study showed that in moderate-severe AR, IgE levels are raised statistically as compared to mild AR and the deficiency of Vitamin D is associated with increasing severity of allergic rhinitis symptoms.

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Section: Discussionsupporting

confidence: 80%

Association of Serum Vitamin D and Immunoglobulin E Levels With Severity of Allergic Rhinitis

Awan¹,

Sohail²,

Naumeri³

et al. 2021

Cureus

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“…The prevalence of self-reported AR has been estimated to range from 2 to 25% in children and from 1 to 40% in adults. The prevalence of confirmed AR in adults in Europe ranges from 17 to 28.5% [2]. Recent studies have shown that the prevalence of AR has increased from 11.1 to 17.6% in Chinese adults [3].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Asarum sieboldii essential oil on ovalbumin induced allergic rhinitis in rat

Zhang

Kang

2020

Bioscience Reports

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Background: The study was aimed to investigate the protective effect of Asarum sieboldii Miq. essential oil (AEO) on ovalbumin (OVA)-induced allergic rhinitis (AR) in rats. Methods and results: Sixty Sprague–Dawley male rats were randomly divided into six groups (n=10): control, model, cetirizine (Cet, 4.65 g/kg), and AEO (0.5, 1.5, 3 g/kg) groups. All animals except the control group received repeated intranasal instillation with 20 μl of 20% OVA in Al(OH)3 saline solvent for 15 days. The control group was intranasally instilled with 5 mg/ml of Al(OH)3 instead of the same procedure. In the 15 days, Cet and AEO were orally administrated for 28 days. At the end of the drug administration, 20 μl of 5% OVA was given to animals to stimulate allergic reaction, then the rat behavioral detection, assessment of the patho-morphological changes in nasal mucosa, and the serum biomarkers were determined. The result showed that AEO could significantly reduce the amount of nasal secretions, sneezing, and the degree of nasal scratching in AR rats with EC50 = 1.5 and 2.8 g/kg, respectively. The degree of nasal mucosal inflammation in AEO group improved, the levels of immunoglobulin E (IgE), histamine, IL-4, IL-5, IL-17 were decreased, and the level of IFN-γ was increased obviously with EC50 = 2 g/kg. Conclusion: The study suggested that the possible mechanism might be related with the inhibition of histamine release and regulation of the cytokine levels, which plays an important role in the treatment of AR.

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“…The relationship between vitamin D status and risk of aeroallergen sensitization and atopic pathology is supported by many observational studies and reviews 9‐12 . However, a Mendelian randomization study design did not find that evidence 29 ; neither did birth cohort studies reveal consistent results, 30,31 finding only an apparent protective effect for lower respiratory tract infection and wheezing 32,33 .…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between vitamin D status and risk of aeroallergen sensitization and atopic pathology is supported by many observational studies and reviews. [9][10][11][12] However, a Mendelian randomization study design did not find that evidence 29 ; neither did birth cohort studies reveal consistent results, 30,31 finding only an apparent protective effect for lower respiratory tract infection and wheezing. 32,33 In addition, trial studies that supplemented with vitamin D found no benefit in preventing allergic diseases, 34 while the only benefit found was for the control of asthma symptoms and in reducing the severity of atopic dermatitis.…”

Section: Limitations and Clinical Applicationmentioning

confidence: 99%

Association between vitamin D status and allergen sensitization in pediatric subjects in the Balearic Islands

Segovia‐Ortí

Bennasar

Sotto-Esteban

et al. 2021

Pediatric Allergy Immunology

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Introduction: Vitamin D has known effects on the immune system, and its deficiency has been associated with allergen sensitization. Material and methods: A retrospective study was performed to evaluate the association between 25(OH)vitamin D (25(OH)D) and specific IgE for the most frequent allergens in our area in children and adolescents. All subjects under 15 years of age with a determination of Phadiatop ® or Phadiatop Infant ® and close serum 25(OH)D determination were included, from 2012 to 2019. From this sample, demographic and analytical variables were collected: specific IgE to Dermatophagoides pteronyssinus;dog and cat dander; grass, olive, and pellitory pollens; egg white; and cow milk; as well as complete blood count analysis and immunoglobulins.Results: A total of 749 subjects were recruited. Clusters according to deficiency, insufficiency, or sufficiency of 25(OH)D showed an association with age, Phadiatop ® , D. pteronyssinus, cat and dog dander specific IgE, and a higher frequency of positive allergen sensitization (P < .05). Logistic regression, compared with vitamin D levels of greater than 30 ng/mL after age adjustment, showed that deficient 25(OH)D was associated with D. pteronyssinus (OR 1.90; 95% CI, 1.25-2.90) and dog dander (OR, 2.10; 1.10-4.02); whereas insufficient 25(OH)D was associated with cat dander (OR, 2.46;) and also with D. pteronyssinus (OR, 1.55; 1.06-2.29) (P < .05). No associations were found between 25(OH) D levels and other analytical parameters. Conclusion:Vitamin D status is associated with sensitization to D. pteronyssinus, and cat and dog dander in children and adolescents, and also with a higher number of positive specific IgE.

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Comparison of 1α-25-dihydroxyvitamin D3 and IgE Levels between Allergic Rhinitis Patients and Healthy People

Cited by 6 publications

References 20 publications

Association of Serum Vitamin D and Immunoglobulin E Levels With Severity of Allergic Rhinitis

Association of Serum Vitamin D and Immunoglobulin E Levels With Severity of Allergic Rhinitis

Protective effect of Asarum sieboldii essential oil on ovalbumin induced allergic rhinitis in rat

Association between vitamin D status and allergen sensitization in pediatric subjects in the Balearic Islands

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