Association between vitamin D status and allergen sensitization in pediatric subjects in the Balearic Islands

Segovia‐Ortí, Raquel; Bennasar, Antònia Barceló; Sotto-Esteban, Diego de; Sanchís, Pilar; Pons, Jaime

doi:10.1111/pai.13513

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…There are few relevant studies now. Segovia-Ortí R et al's study shows Vitamin D status is associated with sensitization to dust mite, and cat and dog dander (13). Some articles believe that there is no correlation between VDD and various allergens (14).…”

Section: Clinical Research On Vitamin D and Allergic Diseasesmentioning

confidence: 99%

A narrative review of vitamin D and food allergy in infants and children

Di¹,

Chen²

2021

Transl Pediatr

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Objective: This article summarizes the research progress on the association of vitamin D and food allergy in infants and children. Background: In recent years, food allergy seriously has affected the quality of life of children and adults. Vitamin D is known to be involved in calcium and phosphorus metabolism, and recent research has demonstrated that vitamin D can also affect the immune regulation of food allergy. Methods: The present study summarizes the research progress on the association of vitamin D and food allergy in infants and children. We searched the PubMed database to identify studies on the association of vitamin D and food allergy published between January 2003 and August 2021.Conclusions: Vitamin D in the body through a number of steps into the final formation of biological effects. The implications of postnatal vitamin D levels for food allergy may be even greater. Vitamin D can prevent the intestinal immune system from being exposed to allergens by maintaining the integrity of the mucosal barrier. Many clinical studies believe that vitamin D supplementation can improve infants' and children's food allergy, however, some show negative results or opposite results. A lot of laboratory studies have confirmed that vitamin D is involved in the immune regulation of food allergy. Evidence indicates there may be a nonlinear relationship between vitamin D and food allergy. Further researches need to be launched.

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Section: Clinical Research On Vitamin D and Allergic Diseasesmentioning

confidence: 99%

A narrative review of vitamin D and food allergy in infants and children

Di¹,

Chen²

2021

Transl Pediatr

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“…In the first original study selected in this editorial, Raquel Segovia‐Orti and colleagues looked at the association between vitamin D status and allergen sensitization in a population of children living in the Balearic Islands 4 . Logistic regression on data from 749 subjects after age adjustment showed that vitamin D deficiency was associated with sensitization to D. pteronyssinus and dog dander, whereas insufficient vitamin D was associated with cat dander and D. pteronyssinus sensitization.…”

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confidence: 99%

Comments on vitamin D and sensitization, asthma treatment, and lung function development

Eigenmann

2021

Pediatric Allergy Immunology

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Comments on vitamin D and sensitization, asthma treatment, and lung function developmentAsthma is the common denominator for the first two reviews featured in this issue. Rossi et al. 1 comment and analyze the complex interactions between the respiratory syncytial virus (RSV) and the airway microbiota, highlighting the fact that viruses such as the RSV might increase the virulence of bacterial pathogens in the airways, but that also a disbalance in the airway microbiota may promote more severe RSV infections.The second review by a group of South-East Asian colleagues focusing on their regional area analyzes how the environment can contribute to our understanding of the pathogenesis of asthma with an emphasis on prevention strategies. 2 The food-induced enterocolitis syndrome (FPIES) is well known to you, but probably less when similar symptoms are provoked by drugs (DIES). Francesca Mori et al. 3 describe new cases and analyze the current literature with a focus on similarities and differences between FPIES and DIES.In the first original study selected in this editorial, Raquel Segovia-Orti and colleagues looked at the association between vitamin D status and allergen sensitization in a population of children living in the Balearic Islands. 4Logistic regression on data from 749 subjects after age adjustment showed that vitamin D deficiency was associated with sensitization to D. pteronyssinus and dog dander, whereas insufficient vitamin D was associated with cat dander and D. pteronyssinus sensitization. They conclude by suggesting that trials are needed to test the effectiveness of vitamin D supplementation against sensitization to specific allergens, rather than clinical symptoms.The role of dietary factors in allergy has been reported in several recent publications in PAI 5-7 ; in addition, the reader will find in recent publications investigations on the effect of vitamin D on the immune system, as well as on allergic diseases. 8-10 Additionally, you may find some interest to look at sensitization patterns reported recently in Northern Europe, and how they may differ from the Spanish study. 11

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