Stool viruses in babies in Glasgow: 1. Hospital admissions with diarrhoea

Madeley, C. R.; Cosgrove, B.; Bell, Eleanor J.; Fallon, R. J.

doi:10.1017/s0022172400056151

Cited by 94 publications

(50 citation statements)

References 16 publications

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“…Adenoviruses, which have been frequently involved in diarrhoea in several countries (Madeley et al 1977;Brandt et al 1979;Uhnoo et al 1984), appear to be uncommon in our population and were detected in only 0-9 % of cases.…”

Section: Discussionmentioning

confidence: 57%

A three-year diagnostic and epidemiological study on viral infantile diarrhoea in Rome

et al. 1988

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SUMMARYRotavirus infection was demonstrated in 168 (293 %) of 573 children hospitalized for acute diarrhoea in Rome between January 1982 and December 1984. Laboratory diagnosis of these infections was made by transmission electron microscopy and enzyme immunoassay techniques with an overall agreement of 91-3%. Astroviruses, adenoviruses and small round viruses were detected in the faeces of 36 patients (6'4 %). Whereas in 1982 rotavirus positive patients were clustered in the winter and following spring, in the following years cases were recorded all year round. The median age of patients with rotavirus infections was 17, 10 and 11.5 months in 1982, 1983 and 1984, respectively. In addition, a smaller number of rotavirus positive cases were admitted in 1983 when compared to those admitted during the previous as well as the subsequent years. It is suggested that a herd immunity was induced in the population by epidemic spread of rotavirus in the first half of 1982.

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Section: Discussionmentioning

confidence: 57%

A three-year diagnostic and epidemiological study on viral infantile diarrhoea in Rome

et al. 1988

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“…The methods for processing and examining the stools were as previously reported (Madeley et al 1977).…”

Section: Virologymentioning

confidence: 99%

“…In the course of a previous study (Madeley et al 1977) we were asked to investigate an outbreak ofenteritis in the post-natal ward in another hospital. Examination of stools from six cases by electron microscopy showed the presence of viruses in all babies.…”

Section: Introductionmentioning

confidence: 99%

Stool viruses in babies in Glasgow: 2. Investigation of normal newborns in hospital

Madeley

Cosgrove

Bell

1978

J. Hyg.

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SummaryThe stools of 37 newborn babies born in hospital were examined for the presence of virus. An extract of every stool passed by each baby was examined in the electron microscope and inoculated into cell cultures. The babies were delivered in four separate maternity units (A–D). All the babies from units A and C (9 babies) were found to be excreting rotavirus though none showed any evidence of diarrhoea. Two of the babies also excreted astrovirus. Subsequently unit A was closed for cleaning and, on reopening with more restrictions on visitors, a further 19 babies were examined. No virus was found in any of their stools, nor was virus observed in the stools of babies from units B and D, where visiting was also more restricted. Visiting restrictions in these units excluded older siblings of the babies. No virus was cultured from any stools in this study.

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“…During the last 13 years, adenoviruses have been detected in stools of patients with gastroenteritis (33,108,110,119,197,232,297,300,324), using the technique of EM (Fig. 1B), but often, they could not be isolated in routine cell cultures.…”

Section: Introductionmentioning

confidence: 99%

Human viral gastroenteritis

Christensen

1989

Clin Microbiol Rev

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During the last 15 years, several different groups of fastidious viruses that are responsible for a large proportion of acute viral gastroenteritis cases have been discovered by the electron microscopic examination of stool specimens. This disease is one of the most prevalent and serious clinical syndromes seen around the world, especially in children. Rotaviruses, in the family Reoviridae, and fastidious fecal adenoviruses account for much of the viral gastroenteritis in infants and young children, whereas the small caliciviruses and unclassified astroviruses, and possibly enteric coronaviruses, are responsible for significantly fewer cases overall. In addition to electron microscopy, enzyme immunoassays and other rapid antigen detection systems have been developed to detect rotaviruses and fastidious fecal adenoviruses in the stool specimens of both nonhospitalized patients and those hospitalized for dehydration and electrolyte imbalance. Experimental rotavirus vaccines have also been developed, due to the prevalence and seriousness of rotavirus infection. The small, unclassified Norwalk virus and morphologically similar viruses are responsible for large and small outbreaks of acute gastroenteritis in older children, adolescents, and adults. Hospitalization of older patients infected with these viruses is usually not required, and their laboratory diagnoses have been limited primarily to research laboratories.

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Stool viruses in babies in Glasgow: 1. Hospital admissions with diarrhoea

Cited by 94 publications

References 16 publications

A three-year diagnostic and epidemiological study on viral infantile diarrhoea in Rome

A three-year diagnostic and epidemiological study on viral infantile diarrhoea in Rome

Stool viruses in babies in Glasgow: 2. Investigation of normal newborns in hospital

Human viral gastroenteritis

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