Surface modification of chitosan films.

Tangpasuthadol, Varawut; Pongchaisirikul, Noppong; Hoven, Vipavee P.

doi:10.1016/s0008-6215(03)00038-7

Cited by 196 publications

(79 citation statements)

References 18 publications

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“…A quitosana é um aminopolissacarídeo biodegradável, hidrofílico, não tóxico e biocompatível obtido a partir da desacetilação alcalina da quitina [1][2][3] . Sua estrutura química é formada pelos copolímeros β-(1→4)-2-amino 2-desoxi-D-glicose e β-(1→4)-2-acetamida 2-desoxi-D-glicose com a presença de grupos amino e grupos hidroxila primário e secundário.…”

Section: Produção E Caracterização De Microesferas De Quitosana Modifunclassified

Produção e caracterização de microesferas de quitosana modificadas quimicamente

et al. 2005

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Resumo: Microesferas de quitosana podem ser empregadas na área de biomaterias, em processos biotecnológicos e como adsorventes. Neste trabalho, foi empregada a técnica de atomização e coagulação para produção dessas microesferas, que permitiu o controle dos parâmetros de operação e por conseqüência a obtenção de microesferas de tamanho e faixas de tamanho específicos. Após a sua obtenção, as microesferas foram modificadas quimicamente com objetivo de estudar as resistências térmica, mecânica e química. Para isso foram empregadas três rotas distintas: a-) reticulação com glutaraldeído; b-) reticulação com epicloridrina e c-) acetilação. As microesferas preparadas apresentaram distribuição de tamanho da ordem de 140 µm com desvio padrão de 11,9 µm. Após as modificações químicas, as microesferas apresentaram temperatura de degradação térmica em torno de 300 °C, aumento da estabilidade química à solução de HCl, e diminuição da resistência mecânica.Palavras-chave: Quitosana, microesferas, atomização, modificação química. Production and Characterization of Chemically Modified Chitosan MicrospheresAbstract: Chitosan microspheres can be used as biomaterial, in biotechnology processes and as adsorbents. This work is concerned with the production of chitosan microspheres using spraying and coagulation processes, which allows us to control the operating parameters and to produce chitosan microspheres of several ranges and sizes. The microspheres were modified chemically in order to study their thermal, mechanical and chemical resistance. The methods used were: 1) crosslinking with glutaraldehyde; 2) crosslinking with epichlorohydrin; 3) acetylation. The microspheres obtained presented mean particle size of 140 µm and standard deviation of 11.9 µm. The modified microspheres showed thermal degradation around 300 °C, an increase of chemical stability using HCl solution and a decrease of mechanical resistance.

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Section: Produção E Caracterização De Microesferas De Quitosana Modifunclassified

Produção e caracterização de microesferas de quitosana modificadas quimicamente

et al. 2005

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“…Thus, significant research efforts have been focused on improving the host response to these materials in terms of cellular behavior. Earlier studies used a variety of methods such as blending, [16] gamma irradiation, [18] chemical reactions [19] and plasma surface modification. [20][21][22][23] The last one of these, plasma surface modification, is a method widely used [23][24][25] to tailor surface functionality by working in different atmospheres.…”

Section: Introductionmentioning

confidence: 99%

Plasma Surface Modification of Chitosan Membranes: Characterization and Preliminary Cell Response Studies

Silva

Luna

Gomes

et al. 2008

Macromolecular Bioscience

130

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Surface modification of biomaterials is a way to tailor cell responses whilst retaining the bulk properties. In this work, chitosan membranes were prepared by solvent casting and treated with nitrogen or argon plasma at 20 W for 10-40 min. AFM indicated an increase in the surface roughness as a result of the ongoing etching process. XPS and contact angle measurements showed different surface elemental compositions and higher surface free energy. The MTS test and direct contact assays with an L929 fibroblast cell line indicated that the plasma treatment improved the cell adhesion and proliferation. Overall, the results demonstrated that such plasma treatments could significantly improve the biocompatibility of chitosan membranes and thus improve their potential in wound dressings and tissue engineering applications.

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“…Fernández et al scaffolds, [40][41][42][43][44] and have concluded that it is due to initial interactions between cells and scaffolds that are dependent on weak bonds such as dipole-dipole. Although it is still not understood how the hydrophobicity or hydrophilicity of materials can regulate cellular activity and tissue regeneration, this is an important parameter to consider when designing a scaffold.…”

Section: Fumarate/ceramic Composite Based Scaffolds For Tissue Enginementioning

confidence: 99%

Fumarate/Ceramic Composite Based Scaffolds for Tissue Engineering: Evaluation of Hydrophylicity, Degradability, Toxicity and Biocompatibility

Fernández¹,

Cortizo²,

Cortizo³

2014

j biomater tissue eng

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The present study was designed to investigate the possible cytotoxicity and biocompatibility of scaffolds based on previously characterized polymeric materials including poly--caprolactone (PCL) or polydiisopropyl fumarate (blended or on their own), with or without hydroxyapatite (HAP). Water contact angle was also evaluated to determine the hydrophylicity of each scaffold. Degradation of different scaffolds was evaluated after a 10-week incubation in Dulbecco's modified eagle medium (DMEM) supplemented with 5% (v/v) fetal bovine serum (FBS). Bone Marrow Stromal Cells (MSC) were grown on different scaffolds in an osteogenic medium, after which alkaline phosphatase activity (ALP) was evaluated. ALP activity increased when MSC were grown on PCL + HAP or Blend + HAP, as compared to PCL or Blend without HAP. The effect of different scaffolds on the proliferation of the macrophage cell line RAW 264.7, production of nitric oxide (NO) and secretion of pro-inflammatory cytokines was examined. After 72 h, macrophages proliferated equally well on all scaffolds, maintaining a rounded morphology. None of the investigated scaffolds induced production of NO or cytokine release into the culture media, suggesting an absence of cytotoxicity. Therefore, these polymer-and HAP-based scaffolds could potentially be used as bone substitute materials.

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Surface modification of chitosan films.

Cited by 196 publications

References 18 publications

Produção e caracterização de microesferas de quitosana modificadas quimicamente

Produção e caracterização de microesferas de quitosana modificadas quimicamente

Plasma Surface Modification of Chitosan Membranes: Characterization and Preliminary Cell Response Studies

Fumarate/Ceramic Composite Based Scaffolds for Tissue Engineering: Evaluation of Hydrophylicity, Degradability, Toxicity and Biocompatibility

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