Intestinal parasites infection: protective effect in rheumatoid arthritis?

Oliveira, Sandra de; Gomides, Ana Paula Monteiro; Mota, Lícia Maria Henrique da; Lima, Caliandra Maria Bezerra Luna; Rocha, Francisco Airton Castro

doi:10.1016/j.rbre.2016.06.004

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…The development of an immunologically healthy condition because of helminth infection is thought to mitigate the incidence of an autoimmune rheumatic disorder that is present. A deeper understanding of the anti-inflammatory mechanisms triggered by helminth infection or their secretory products is remained elusive [92,93].…”

Section: Protective Role Of Parasites In Autoimmune Diseasesmentioning

confidence: 99%

Impact of parasitic infection on human gut ecology and immune regulations

Ahsan

Abdullah

2021

transl med commun

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The human body harbors trillions of microbes collectively known as microbiota. The human gut microbiota is importantly involved in most of the human metabolic and regulatory pathways. The gut microbiota needs to be balanced for the health of the host. Several factors are involved in the distribution of microbiota in the human body, in most cases these microbiotas are commensals, but some circumstances lead to serious disorders and the development of infections from microbiota. When parasites colonize the gut, the balance between the host and the gut microbiota can be disturbed. Parasitic invasion in the gut is associated with unhygienic conditions including contaminated food and water. Parasitic invasion in the gut induces the immune response to recognize and eliminate pathogens. The current study highlights the immune system’s response to disruption of normal intestinal microbiota and parasitic infections.

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Section: Protective Role Of Parasites In Autoimmune Diseasesmentioning

confidence: 99%

Impact of parasitic infection on human gut ecology and immune regulations

Ahsan

Abdullah

2021

transl med commun

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“…Recently, RA is described as an autoimmune disease mediated by T cells, especially effector The T helper 17 cells (Th17 cells) [24]. The protective role of T regulatory cells (Treg cells) and the pro-inflammatory role of Th17 (by secreting IL-17) have been elucidated and emphasized in the pathogenesis of RA.…”

Section: Balance Between Th17 and Tregmentioning

confidence: 99%

Five Balances in the Management of Rheumatoid Arthritis

Zou¹

2017

JBM

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Rheumatoid arthritis (RA) is the most common chronic autoimmune joint disease. The etiology of RA is complex, and then it is impossible to cure completely today and it should be individualized treatment. Immune system is complex. Existing statistical techniques based on reductionism cannot discover many relevant disease risk factors and complex interaction relationship. The disease network model based on complex network is important for the analysis and treatment of RA disease. In this Review, we have found five important layers of RA complex network and presented five balances regulating strategy in the management of RA. We have followed up one RA patient (wife of the author) for one year using this strategy, and the management effect is good. This Review argues RA is self-limiting to some extent, and good management with five balances regulating strategy would have positive significance, among which the balance between neuroendocrine system and immune system is the most important. During the day, glucocorticoid plays an important role in controlling inflammation, and human growth hormone plays an important role in eliminating inflammation during the slow-wave sleep at night. Five balances core concepts can shed light on the management of other causes of arthritis.

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