The Relevance of Neuroscience Research Networks for Brazilian Science

Kapczinski, Flávio; Romano-Silva, Marco Aurélio

doi:10.1016/j.rbp.2012.08.001

Cited by 6 publications

(13 citation statements)

References 5 publications

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“…The C3, CFI, and C4BPα proteins may represent a plasma-based diagnostic biomarker panel, which could aid BD diagnosis or be used to monitor BD progression. Current research appears to support the view that plasma levels of C3 are elevated in MDD patients, while changes in C3 in BD is closely associated with the state of disease (Santos Sória et al, 2012 ), and there is also mounting evidence of the C4BPα and CFI levels being disturbed in several psychiatric disorders, elevated peripheral C4BP levels have been reported in Alzheimer’s disease (Trouw et al, 2008 ), and the mean level of CFI activity in autistic subjects suggesting that high CFI activity may have an impact on the development of autism (Momeni et al, 2012 ). These findings seem to suggest that the autoimmune system may provide promising biomarkers for psychiatry.…”

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confidence: 69%

Comparative proteomic analysis of plasma from bipolar depression and depressive disorder: identification of proteins associated with immune regulatory

et al. 2015

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confidence: 69%

Comparative proteomic analysis of plasma from bipolar depression and depressive disorder: identification of proteins associated with immune regulatory

et al. 2015

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“…However, in a study reported by Akcan et al( 6 ) found that serum C4 levels were significantly reduced in chronic BD patients and the C4 mRNA expressions were elevated in a compensatory way. Furthermore, Santos and his colleagues failed to detect significant difference between HC and BD patients in euthymic state( 14 ). In spite of these conflict results, this would be understandable when considering the huge discrepancy of sample size and the subjects recruited.…”

Section: Discussionmentioning

confidence: 99%

Increased Serum C3 and Decreased UA in Patients of Bipolar Disorder in Chinese Han Population

et al. 2018

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The aim of this study is to explore the changes and clinical significance of serum C3, C4, hypersensitive C-reactive protein (hsCRP) and uric acid (UA) in patients of bipolar disorder (BD). In this case-control study, we recruited 141 BD patients from The Second Xiangya Hospital, Central South University, and 151 age and gender matched healthy controls (HC) from the health management central of The Second Xiangya Hospital. These patients were divided into two subgroups based on medicines use: 91 patients were treated with psychiatric drugs and 50 patients were drugs free, or four subgroups based on mood states: 54 patients in manic/hypomanic phase, 30 patients in depressive phase, 52 patients in euthymic phase and 5 patients in mixed phase. Serum levels of C3, C4, hsCRP and UA were measured in all subjects. The serum C3 levels in BD patients (0.9981 ± 0.1849 g/L) were significantly lower than that in HC group (1.0637 ± 0.2186 g/L), especially the drugs free subgroup and the euthymic subgroup (0.975 ± 0.153 and 0.983 ± 0.182 g/L), while the serum UA levels were significantly higher (354.6 ± 90.4 vs. 332.9 ± 88.7 μmol/L), especially the drug-treated subgroup and manic/hypomanic subgroup (361.56 ± 93.20 and 376.70 ± 88.89 μmol/L), and rates of hyperuricaemia (31.91 vs. 17.88%) were significantly higher in BD patients than in HC group. The serum C4 and hsCRP levels in HC group showed no significant difference with BD patients in whole or those subgroups. These findings suggested that the complement and purinergic systems of BD patients might be disrupted, the UA levels could be a potential marker in manic phase and the C3 might be the marker of therapeutic evaluation of BD patients.

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“…Hakobyan et al showed that C3 hemolytic activity was 2.01-fold higher in SCZ patients than in healthy controls [32]. dos Santos Sória et al reported that C3 was significant higher in SCZ patients than in control subjects [33]. Nsaiba et al also demonstrated that C3 was increased in SCZ patients [34].…”

Section: Discussionmentioning

confidence: 99%

Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population

Zhang

Zhou

et al. 2018

Cell Physiol Biochem

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Background/Aims: Schizophrenia is a severe psychiatric disorder, and complement 3 (C3) is closely related to schizophrenia. We investigated the association between C3 polymorphisms and schizophrenia in a Northeast Han Chinese population. Methods: A total of 2240 Chinese people, consisting of 1086 patients with schizophrenia and 1154 healthy controls, were recruited for this study. Ten single nucleotide polymorphisms (SNPs; rs11569562, rs344555, rs2241393, rs2241392, rs11569514, rs445750, rs451760, rs11672613, rs2230205, and rs2250656) in C3 were selected and genotyped. Results: Genotype distribution analysis indicated that rs11569514 was significantly associated with schizophrenia. In the dominant model (AA vs. GG+GA genotypes), we found a significant protective effect for rs344555 against schizophrenia (odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.53–0.99, P = 0.04). In the codominant model (TT vs. AA), we found a significant risk effect for rs11569514 on schizophrenia (OR: 4.39, 95% CI: 2.06–9.37, P < 0.001). Haplotypes, including TG (rs11569562 and rs344555), TGG (rs11569562-rs344555-rs2241393), AG (rs344555-rs2241393), CGGGT (rs11569562-rs344555-rs2241393-rs2241392-rs11569514), and ACGTG (rs11569514-rs445750-rs451760-rs11672613-rs2230205), showed either a risk or protective role for schizophrenia. Conclusions: SNP rs11569514 in C3 and haplotypes of C3 variants were associated with schizophrenia in a Han Chinese population.

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The Relevance of Neuroscience Research Networks for Brazilian Science

Cited by 6 publications

References 5 publications

Comparative proteomic analysis of plasma from bipolar depression and depressive disorder: identification of proteins associated with immune regulatory

Comparative proteomic analysis of plasma from bipolar depression and depressive disorder: identification of proteins associated with immune regulatory

Increased Serum C3 and Decreased UA in Patients of Bipolar Disorder in Chinese Han Population

Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population

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