Allergic sensitization pattern of patients in Brazil

Aranda, Carolina Sánchez; Cocco, Renata Rodrigues; Pierotti, Felipe Faria; Sarinho, Emanuel Sávio Cavalcanti; Sano, Flávio; Porto, Arnaldo; Chong-Neto, Herberto José; Goudouris, Ekaterini; Moraes, Lillian; Wandalsen, Neusa Falbo; Mallozi, Márcia C.; Pastorino, Antônio Carlos; Franco, Jackeline; Chavarria, Maria Letícia; Borres, Magnus P.; Solé, Dírceu

doi:10.1016/j.jped.2020.08.005

Cited by 7 publications

(7 citation statements)

References 27 publications

(42 reference statements)

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“…Also in this study, children with eczema who were sensitive to HDM had respiratory allergic diseases. In a study by Aranda CS, mite sensitization was the most frequent in 470 children with allergy, with a predominance of Der p 1 and Der p 2 sensitization (78.3% and 79.4%, respectively) [16].…”

Section: Discussionmentioning

confidence: 96%

House dust mite sensitivity in atopic children with Dectin-1 rs7309123 polymorphism

Mozyrska¹

2022

pja

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Introduction: Sensitization to house dust mites is common in patients with atopic dermatitis. Dectin-1 polymorphism can affect the recognition of house dust mite allergens in the skin. Aim: To investigate the prevalence of sensitization to house dust mites in children with atopic dermatitis and the role of Dectin-1 rs7309123 polymorphism in the development of sensitivity to house dust mites. Material and methods:The study included 101 patients with atopic dermatitis. Genotyping of the Dectin-1 rs7309123 was performed in the patient group using real-time PCR. Measurements of sIgE to dust mites were performed by Western blotting. Results: Sensitization to house dust mites was found in 48.5% of the children. The presence of sIgE to HDM in patients with AD was significantly associated with concomitant allergic rhinitis (OR = 2.593 (1.096-6.133)) and in the group of children with both concomitant allergic diseases ). There was statistically significant difference in the distribution of genotypes in patients with elevated serum IgE to HDM and among the children with normal levels for CG and GG). Conclusions:The susceptibility to dust mites among children with atopic dermatitis is 48.5%. Dectin-1 is involved in the development of HDM-induced allergic inflammation in skin because polymorphism rs7309123 of the Dectin-1 gene may affect percutaneous sensitization to HDM in patients with AD, and the inhibition of signalling pathways of Dectin-1 may be an efficient therapeutic strategy.

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Section: Discussionmentioning

confidence: 96%

House dust mite sensitivity in atopic children with Dectin-1 rs7309123 polymorphism

Mozyrska¹

2022

pja

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“…We saw much lower rates of sensitization (<7%) to the tropical mite, Blomia tropicalis, and the storage mite Chortoglyphus arcuatus compared to Dermatophagoides spp. B. tropicalis is an important source of allergens in tropical and subtropical settings and has been associated with respiratory allergies (6,38), atopic dermatitis, and food allergies (39). Mite fauna in house dust samples from tropical settings including Ecuador are highly diverse (6,40,41) and vary geographically between such settings (6).…”

Section: Discussionmentioning

confidence: 99%

“…B . tropicalis is an important source of allergens in tropical and subtropical settings and has been associated with respiratory allergies ( 6 , 38 ), atopic dermatitis, and food allergies ( 39 ). Mite fauna in house dust samples from tropical settings including Ecuador are highly diverse ( 6 , 40 , 41 ) and vary geographically between such settings ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

Patterns of Allergic Sensitization and Factors Associated With Emergence of Sensitization in the Rural Tropics Early in the Life Course: Findings of an Ecuadorian Birth Cohort

et al. 2021

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Introduction: There are limited data on emergence of allergic sensitization (or atopy) during childhood in tropical regions.Methods: We followed a birth cohort of 2,404 newborns to 8 years in tropical Ecuador and collected: risk factor data by maternal questionnaires periodically from birth; atopy was measured by skin prick test reactivity (SPT) to aeroallergens in parents, and aeroallergens and food allergens in children at 2, 3, 5, and 8 years; and stool samples for soil-transmitted helminths (STH) from children periodically to 8 years and from parents and household members at the time of recruitment of cohort children. Data on risk factors were measured either at birth or repeatedly (time-varying) from birth to 8 years. Longitudinal repeated-measures analyses were done using generalized estimating equations to estimate the age-dependent risk of positive SPT (SPT+) to any allergen or mite during early childhood.Results: SPT+ to any allergen was present in 29.0% of fathers and 24.8% of mothers, and in cohort children increased with age, initially to mite but later to cockroach, reaching 14.8% to any allergen (10.7% mite and 5.3% cockroach) at 8 years. Maternal SPT+, particularly presence of polysensitization (OR 2.04, 95% CI 1.49–2.77) significantly increased the risk of SPT+ during childhood, while household overcrowding at birth decreased the risk (OR 0.84, 95% CI 0.72–0.98). For mite sensitization, maternal polysensitization increased (OR 2.14, 95% CI 1.40–3.27) but rural residence (OR 0.69, 95% CI 0.50–0.94) and birth order (3rd−4th vs. 1st−2nd: OR 0.71, 95% CI 0.52–0.98) decreased the risk. Time-varying exposures to agricultural activities (OR 0.77, 95% CI 0.60–0.98) and STH parasites (OR 0.70, 95% CI 0.64–0.91) during childhood decreased while anthelmintics increased the childhood risk (OR 1.47, 95% CI 1.05–2.05) of mite sensitization.Conclusion: Our data show the emergence of allergic sensitization, primarily to mite and cockroach allergens, during childhood in tropical Ecuador. A role for both antenatal and post-natal factors acting as potential determinants of SPT+ emergence was observed.

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“…In Brazil, allergens derived from house dust mites are associated with the development of AR and asthma, and also atopic dermatitis. 57 , 58 , 59 , 60 , 61 , 62 , 63 The formulation of the extract used for AIT should be chosen based on the skin prick test result and/or serum level of specific IgE.…”

Section: Handling and Choice Of Allergenic Extractsmentioning

confidence: 99%

Good clinical practice recommendations in allergen immunotherapy: Position paper of the Brazilian Association of Allergy and Immunology – ASBAI

Aarestrup¹,

Taketomi²,

Galvão³

et al. 2022

World Allergy Organization Journal

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Allergic sensitization pattern of patients in Brazil

Cited by 7 publications

References 27 publications

House dust mite sensitivity in atopic children with Dectin-1 rs7309123 polymorphism

House dust mite sensitivity in atopic children with Dectin-1 rs7309123 polymorphism

Patterns of Allergic Sensitization and Factors Associated With Emergence of Sensitization in the Rural Tropics Early in the Life Course: Findings of an Ecuadorian Birth Cohort

Good clinical practice recommendations in allergen immunotherapy: Position paper of the Brazilian Association of Allergy and Immunology – ASBAI

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