Influence of the antiretroviral therapy on the growth pattern of children and adolescents living with HIV/AIDS

Are There Effects of Antiretroviral Usage, Caregiver Stigma, Caregiver Burden, and Caregiver Coping on the Quality of Life of Indonesian Children with HIV/AIDS?

“…This study found that ARV drugs improves the quality of life of Indonesian children with HIV/AIDS, which is a condition consistent with some previous studies [17][18][19]. ARV therapy suppresses viral replication and reduces viral load in blood thereby boosting immune system [20], and has been shown to improve physical functioning of children with HIV/AIDS [21]. Regular consumption of ARVs helps the development of children with HIV/AIDS [22].…”

“…The caregiver stigma measurement obtained a value of 21.7 ± 2.06, with a median value of 22 (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). There was no signi cant effect between caregiver stigma on the quality of life of Indonesian children with HIV/AIDS (β = 0.064; p = 0.548), with value of each subscale as follows: physical function (β = 0.023; p = 0.845), emotional function (β = -0.066; p = 0.608), social function (β = 0.007; p = 0.957), and school function (β = 0.097; p = 0.418).…”

“…quality of life (71.7%; β = 0.683; p < 0.001). Caregiver stigma value was 21.7 ± 2.06, with a median value of 22 (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26); β = 0.064; p = 0.548). Participants had moderate and mild caregiver burden, with percentage of 50.9% and 49.1%, respectively (β = 0.058; p = 0.593).…”

Comparison of Muscle Strength, Aerobic Capacity and Body Composition between Healthy Adolescents and Those Living with HIV: A Systematic Review and Meta-Analysis

“…Concerning the difference in body composition of patients living with HIV, there is an association with the interaction between virus, HAART, and host [ 29 ]. The change in phenotype includes body fat distribution abnormalities, which represent increased risk for premature cardiovascular diseases and accumulation of visceral fat, which at high levels is associated with chronic inflammation and metabolic disorders [ 5 ].…”

“…The use of HAART does not fully reverse the effects of HIV child growth [ 30 ]. However, a systematic review that addressed the influence of antiretroviral therapy on the growth pattern in children and adolescents living with HIV indicated that ART may influence weight and height development, indicating that the earlier the diagnosis of infection and, concomitantly, beginning of the use of combination antiretroviral therapy, the lower the impairment of growth compared to healthy children [ 29 ].…”