Comparison of Muscle Strength, Aerobic Capacity and Body Composition between Healthy Adolescents and Those Living with HIV: A Systematic Review and Meta-Analysis

Medeiros, Rafaela Catherine da Silva Cunha de; Santos, Ivanaldo; Oliveira, Anna Luiza Vasconcelos de; Goes, Carlos Jean Damasceno de; Medeiros, Jason Azevedo de; Silva, Tatiane Andreza Lima da; Araújo, Juliany de Souza; Varela, Phelipe Wilde de Alcântara; Cobucci, Ricardo Ney; Cabral, Breno Guilherme de Araújo Tinôco

doi:10.3390/ijerph18115675

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…However, the results from these scoping reviews show the lack of knowledge in terms of understanding the importance of the physical activity level as a moderating factor in the relationship between HIV infection/ART use and the health-related physical fitness components in HIV-diagnosed children and adolescents in terms of the physical activity level investigation [48,49,53]. Another limitation of the interpretation of these studies is the difference between HIVdiagnosed children and adolescents when compared whit their peers without a diagnosis of HIV infection [54,55].…”

Section: Discussionmentioning

confidence: 99%

“…The preliminary search was conducted in January 2024, through the search tools of the Medical Literature Analysis and Retrieval System Online (MEDLINE) (via PubMed), Cochrane Library, Joana Briggs Institute (JBI) Evidence Synthesis and Open Science Framework (OSF) to identify scoping reviews or systematic reviews that mapped the healthrelated physical fitness of HIV-diagnosed children and adolescents. Two systematic reviews with meta-analysis were found, which aimed to investigate muscle function and aerobic capacity in HIV-diagnosed patients [54], and to investigate the aerobic capacity, muscle strength and body composition of HIV-diagnosed adolescents [55]. However, those reviews included only studies that compared results of HIV-diagnosed participants with…”

Section: Preliminary Searchmentioning

confidence: 99%

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Health-Related Physical Fitness Evaluation in HIV-Diagnosed Children and Adolescents: A Scoping Review

de Castro,

de Lima,

Silva

2024

IJERPH

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Background: Health-related physical fitness has been widely used to investigate the adverse effects of HIV infection/ART in children and adolescents. However, methods/protocols and cut-points applied for investigating health-related physical fitness are not clear. The aim of this scoping review was to map the literature to identify gaps in knowledge regarding the methods/protocols and cut-points. Methods: A scoping review, following the Joana Briggs Institute (JBI) guidelines, was conducted through ten major databases. Search followed the PCC strategy to construct block of terms related to population (children and adolescents), concept (health-related physical fitness components) and context (HIV infection). Results: The search resulted in 7545 studies. After duplicate removal, titles and abstracts reading and full text assessment, 246 studies were included in the scoping review. Body composition was the most investigated component (n= 244), followed by muscular strength/endurance (n = 23), cardiorespiratory fitness (n = 15) and flexibility (n = 4). The World Health Organization growth curves, and nationals’ surveys were the most reference values applied to classify body composition (n = 149), followed by internal cut-points (n = 30) and cut-points developed through small populations (n = 16). Cardiorespiratory fitness was classified through cut-points from three different assessment batteries, as well as cut-points developed through studies with small populations, muscular strength/endurance and flexibility were classified through the same cut-points from five different assessment batteries. Conclusions: The research on muscular strength/endurance, cardiorespiratory fitness and flexibility has been scarcely explored. The lack of studies that investigated method usability as well as reference values was evidenced.

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Section: Discussionmentioning

confidence: 99%

Section: Preliminary Searchmentioning

confidence: 99%

Health-Related Physical Fitness Evaluation in HIV-Diagnosed Children and Adolescents: A Scoping Review

de Castro,

de Lima,

Silva

2024

IJERPH

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“…It is known that nutritional counseling and exercise interventions in adults with HIV are effective in treating obesity, fat redistribution, and metabolic abnormalities, however, in the pediatric population, investigations need to be further examined [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. Evidence suggests that an approach of anticipation and accountability for nutrition and concern with the level of physical activity can improve the results and help minimize the adverse consequences (metabolic, cardiovascular, and psychological) of HIV [ 1 , 38 , 39 ], mainly during the development and maturation phases [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of Healthy Habits Counseling on Biochemical and Metabolic Parameters in Children and Adolescents with HIV: Longitudinal Study

et al. 2021

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We analyze the influence of dietary counseling and physical activity on biochemical and metabolic parameters in children and adolescents with HIV. A longitudinal experimental study, including three analyses: At the beginning, 4th month, and 8th month. A sample of 18 subjects with HIV of both sexes, mean age 10.4 ± 4.50 years. Usual food intake (24 h recall and food intake marker), level of habitual physical activity, biochemical parameters, resting metabolic rate, as well as body composition (dual-energy X-ray absorptiometry), biological maturation, and anamnesis with clinical data and socioeconomic were evaluated. There was an effect of time on the reduction of blood glucose and triglycerides and the resting metabolic rate. There was a significant increase in fruit consumption throughout the study. The consumption of soft drinks decreased when comparing analysis periods 1 and 2, however, it increased again in analysis period 3. There was no significant effect of time on the set of variables related to a food recall. Counseling healthy habits and regular clinical follow-up were relevant for improving biochemical parameters (glucose, triglyceride, HDL cholesterol), maintaining the resting metabolic rate, increasing fruit consumption, and decreasing the consumption of soft drinks, in part of the time, of children and adolescents with HIV. Finally, we emphasize that counseling positively influenced healthy habits, and these, in turn, improved health-related parameters.

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“…Those reported are often small, lack a control population [10,11], or focus on treatment-naive individuals [12]. A recent systematic review of just five cross-sectional studies (none in Africa), totalling 197 adolescents (age 16-18 years) living with HIV, identified reduced muscle strength and physical fitness compared with uninfected peers [13]. In adults, findings are mixed, for example, raltegravir-based therapy has been associated with skeletal muscle toxicity [14], whilst tenofovir alafenamide (TAF) has been associated with greater muscle mass in men [15].…”

Section: Introductionmentioning

confidence: 99%

Perinatal HIV infection is associated with deficits in muscle function in children and adolescents in Zimbabwe

Gregson,

Rehman,

Rukuni

et al. 2023

Aids

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Objectives: :To determine how muscle strength, power, mass, and density (i.e. quality) differ between children living with HIV (CWH) and those uninfected, and whether antiretroviral therapy (ART) regime is associated with muscle quality. Design: :A cross-sectional study in Harare, Zimbabwe. Methods: :The study recruited CWH aged 8–16years, taking ART for ≥2years, from HIV clinics, and HIV-uninfected children from local schools. Muscle outcomes comprised grip strength measured by hand-held Jamar dynamometer, lower-limb power measured by standing long-jump distance, lean mass measured by dual-energy X-ray absorptiometry, and muscle density (reflecting intramuscular fat) by peripheral quantitative computed tomography. Linear regression calculated adjusted mean differences (aMD) by HIV status. Results: :Overall, 303 CWH and 306 without HIV, had mean(SD) age 12.5(2.5) years, BMI 17.5(2.8), with 50% female. Height and fat mass were lower in CWH, mean differences(SE) 7.4(1.1)cm and 2.7(0.4)kgs, respectively. Male CWH had lower grip strength (aMD 2.5[1.1,3.9]kg, P < 0.001), long-jump distance (7.1[1.8,12.5]cm, P = 0.006), muscle density (0.58[0.12,1.05]mg/cm3, P = 0.018, but not lean mass 0.06[-1.08,1.21]kg, P = 0.891) versus boys without HIV; differences were consistent but smaller in females. Mediation analysis suggested the negative effect of HIV on jumping power in males was partially mediated by muscle density (P = 0.032). CWH taking tenofovir disoproxil fumarate (TDF) had lower muscle density (0.56[0.00,1.13]mg/cm3, P = 0.049) independent of fat mass, than CWH on other ART. Conclusions: :Perinatally-acquired HIV is associated, particularly in males, with reduced upper and lower-limb muscle function, not mass. Intra-muscular fat (poorer muscle quality) partially explained reductions in lower-limb function. TDF is a novel risk factor for impaired muscle quality.

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Comparison of Muscle Strength, Aerobic Capacity and Body Composition between Healthy Adolescents and Those Living with HIV: A Systematic Review and Meta-Analysis

Cited by 5 publications

References 34 publications

Health-Related Physical Fitness Evaluation in HIV-Diagnosed Children and Adolescents: A Scoping Review

Health-Related Physical Fitness Evaluation in HIV-Diagnosed Children and Adolescents: A Scoping Review

Influence of Healthy Habits Counseling on Biochemical and Metabolic Parameters in Children and Adolescents with HIV: Longitudinal Study

Perinatal HIV infection is associated with deficits in muscle function in children and adolescents in Zimbabwe

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