One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing

Wan, Peng; Wang, Weidan; Zheng, Lizhen; Qin, Ling; Yang, Ke

doi:10.1016/j.jmst.2020.10.055

Cited by 17 publications

(5 citation statements)

References 23 publications

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“…In the studies performed to date, a wide range of antihyperlipidemics [ 94 ], analgesic and anti-inflammatory drugs [ 91 , 108 ], antibiotics [ 210 ], bisphosphonates [ 30 ], selective estrogen receptor modulators [ 211 ], and growth factors [ 40 ] have been incorporated into medical implant coatings with the aim of preventing postoperative complications and inducing adequate acceptance and integration of the implant into the body. The drug release is strongly influenced by factors such as the type and physiochemical properties of the selected drug, the coating and the implant, the deposition technique, the focal tissue environment, and the method of incorporating the drug into the coatings, indicating different interactions between the drug and the coating material [ 38 , 212 ].…”

Section: Controlled Releasementioning

confidence: 99%

“…Furthermore, the inclusion of antibiotics in implant coatings is recommended, as improper surgery and postoperative contamination from nearby tissues or hematogenous sources often lead to infections [ 25 ]. The addition of growth factors and osteoclast inhibitors has a positive effect on the quality of newly formed bone tissue [ 26 , 27 , 28 , 29 , 30 ], whereas the addition of anticoagulants may reduce the risk of clot formation and improve the blood compatibility of the biomaterials without affecting cell proliferation [ 31 ]. A number of factors influence the kinetics of the drug release, with the selection of an appropriate coating material and coating deposition technique (e.g., 3D printing, electrospinning [ 32 ], electrophoretic deposition [ 30 ], dip coating [ 33 ], drop casting [ 34 ], sol-gel deposition [ 35 ], biomimetic deposition [ 36 ], layer-by-layer deposition (LbL) [ 15 ], anodization [ 37 ], etc.)…”

Section: Introductionmentioning

confidence: 99%

“…The addition of growth factors and osteoclast inhibitors has a positive effect on the quality of newly formed bone tissue [ 26 , 27 , 28 , 29 , 30 ], whereas the addition of anticoagulants may reduce the risk of clot formation and improve the blood compatibility of the biomaterials without affecting cell proliferation [ 31 ]. A number of factors influence the kinetics of the drug release, with the selection of an appropriate coating material and coating deposition technique (e.g., 3D printing, electrospinning [ 32 ], electrophoretic deposition [ 30 ], dip coating [ 33 ], drop casting [ 34 ], sol-gel deposition [ 35 ], biomimetic deposition [ 36 ], layer-by-layer deposition (LbL) [ 15 ], anodization [ 37 ], etc.) being particularly important, as they dictate the final shape of the drug delivery system, thus allowing a controlled and prolonged release for up to several months [ 38 , 39 , 40 , 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

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Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Kravanja

Finšgar

2021

Biomedicines

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The development of bioactive coatings for orthopedic implants has been of great interest in recent years in order to achieve both early- and long-term osseointegration. Numerous bioactive materials have been investigated for this purpose, along with loading coatings with therapeutic agents (active compounds) that are released into the surrounding media in a controlled manner after surgery. This review initially focuses on the importance and usefulness of characterization techniques for bioactive coatings, allowing the detailed evaluation of coating properties and further improvements. Various advanced analytical techniques that have been used to characterize the structure, interactions, and morphology of the designed bioactive coatings are comprehensively described by means of time-of-flight secondary ion mass spectrometry (ToF-SIMS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), 3D tomography, quartz crystal microbalance (QCM), coating adhesion, and contact angle (CA) measurements. Secondly, the design of controlled-release systems, the determination of drug release kinetics, and recent advances in drug release from bioactive coatings are addressed as the evaluation thereof is crucial for improving the synthesis parameters in designing optimal bioactive coatings.

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Section: Controlled Releasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Kravanja

Finšgar

2021

Biomedicines

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“…The process requires a short process time and gives the ability to produce interconnected porous coatings with controlled thicknesses up to 2 mm [120]. The EPD technique also allows the incorporation of bioactive ingredients such as antibiotics [121] and zoledronate (medication used to treat several bone diseases) [122]. The main issues are related to the coating adhesion, occurrence of cracks and difficult scalability [123].…”

Section: Electrochemical Methodsmentioning

confidence: 99%

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Nikolova

Apostolova

2022

Materials

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To fix the bone in orthopedics, it is almost always necessary to use implants. Metals provide the needed physical and mechanical properties for load-bearing applications. Although widely used as biomedical materials for the replacement of hard tissue, metallic implants still confront challenges, among which the foremost is their low biocompatibility. Some of them also suffer from excessive wear, low corrosion resistance, infections and shielding stress. To address these issues, various coatings have been applied to enhance their in vitro and in vivo performance. When merged with the beneficial properties of various bio-ceramic or polymer coatings remarkable bioactive, osteogenic, antibacterial, or biodegradable composite implants can be created. In this review, bioactive and high-performance coatings for metallic bone implants are systematically reviewed and their biocompatibility is discussed. Updates in coating materials and formulations for metallic implants, as well as their production routes, have been provided. The ways of improving the bioactive coating performance by incorporating bioactive moieties such as growth factors, osteogenic factors, immunomodulatory factors, antibiotics, or other drugs that are locally released in a controlled manner have also been addressed.

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“…In one-step electrochemical deposition of drug coated surfaces, osteoblasts have been shown to proliferate and differentiate osteogenically, but osteoclasts are not significantly inhibited. This may improve bone formation and decrease osteoporosis-related bone resorption near magnesium-based implants [ 91 ]. Bioactive interfaces loaded with 99Tc-MDP exhibited the strongest osseointegration with a native bone when implanted into osteoporotic rabbits’ distal femoral defects.…”

Section: Conventional Drug-eluting Implantsmentioning

confidence: 99%

Recent Advancements in Metallic Drug-Eluting Implants

et al. 2023

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Over the past decade, metallic drug-eluting implants have gained significance in orthopedic and dental applications for controlled drug release, specifically for preventing infection associated with implants. Recent studies showed that metallic implants loaded with drugs were substituted for conventional bare metal implants to achieve sustained and controlled drug release, resulting in a desired local therapeutic concentration. A number of secondary features can be provided by the incorporated active molecules, including the promotion of osteoconduction and angiogenesis, the inhibition of bacterial invasion, and the modulation of host body reaction. This paper reviews recent trends in the development of the metallic drug-eluting implants with various drug delivery systems in the past three years. There are various types of drug-eluting implants that have been developed to meet this purpose, depending on the drug or agents that have been loaded on them. These include anti-inflammatory drugs, antibiotics agents, growth factors, and anti-resorptive drugs.

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One-step electrodeposition synthesis of bisphosphonate loaded magnesium implant: A strategy to modulate drug release for osteoporotic fracture healing

Cited by 17 publications

References 23 publications

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Recent Advancements in Metallic Drug-Eluting Implants

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