Hypovitaminosis D in patients with Crohn's disease

Rebouças, Priscilla Clímaco; Netinho, João Gomes; Cunrath, Geni Satomi; Ronchi, Luiz Sérgio; Melo, Marcelo Maia Caixeta de; Filho, Francisco de Assis Gonçalves; Muniz, Rafaela Cristina Coelho; Martins, Alissonn Teixeira Silva; Oliveira, Rafael Andrade de; Costa, Ricardo Mendonça

doi:10.1016/j.jcol.2016.03.001

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…The inclusion of vitamin D blood dosage level in the habitual prenatal care could be an interesting action as rickets prophylaxis in newborns and for preeclampsia. We believe, that though this study was the first step, new aspects should be evaluated and addressed in the near future [27][28][29][30][31][32]. But now our results show that low blood levels of vitamin D in the first trimester are associated with pre-eclampsia, but not with birth weight.…”

Section: Discussionmentioning

confidence: 88%

Blood Dosage of Vitamin D in Pregnant Women and Association with Preeclampsia and Fetal Low Weight

Ba¹,

Cac²,

Hsr³

et al. 2020

Asp Biomed Clin Case Rep

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Objective: The present study aimed to evaluate the vitamin D blood dosage during the three gestational trimesters, while identifying the frequency of pregnant women in the normal range, the variance in the three periods and evaluate the association between vitamin D and the obstetric complications such as preeclampsia, diabetes, and weight of the newborn. Methods: This is a longitudinal study with pregnant and non-pregnant women, from which there was collected data of anamneses, physical exam, obstetric info, as well as milk consumption habits, sunscreen and sun exposure, and also the vitamin D blood dosage. Results: There were 91 Pregnant Women studied, from whom the comparison between the vitamin D dosages identified the absence of gestation as a protective factor for VDD; the tendency for lower levels of supplementations when the workplace is in an external environment; the association between vitamin D and pre-eclampsia in the first trimester. Conclusion: The most relevant consequences from VDD were pre-eclampsia in the first trimester, the absence of gestation as a protective factor for VDD, and the need to consider the workplace before supplementation.

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Section: Discussionmentioning

confidence: 88%

Blood Dosage of Vitamin D in Pregnant Women and Association with Preeclampsia and Fetal Low Weight

Ba¹,

Cac²,

Hsr³

et al. 2020

Asp Biomed Clin Case Rep

View full text Add to dashboard Cite

show abstract

“…This can be explained by the low day-today exposure to sunlight, poor exposure of the body due to clothing, and the frequent use of sunscreens. 8,22 The active form of vitamin D is present in various tissues and organs that are not related to bone or calcium metabolism. 1,25-Dihydroxyvitamin D functions in processes such as cell differentiation, proliferation and apoptosis, hormone secretion, and in the immune system.…”

Section: Discussionmentioning

confidence: 99%

Deficiency of vitamin D and its relation with clinical and laboratory activity of inflammatory bowel diseases

Scolaro

Barretta

Matos

et al. 2018

Journal of Coloproctology

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Objective To evaluate the serum concentrations of vitamin D and their relation with inflammatory bowel diseases. Methods This is a quantitative and descriptive study, with individuals assisted by the interdisciplinary ambulatory of Inflammatory Bowel Disease of the Family and Community Health Unit of Itajaí/SC from September 2015 to October 2016. Socioeconomic data, life habits, and biochemical tests were collected, with the use of clinical indexes of classification of the disease activity: Harvey-Bradshaw Index (Crohn's Disease) and Partial Mayo Score (Chronic Nonspecific Ulcerative Colitis). Results Of the 60 patients evaluated, 57% ( n = 34) had Crohn's Disease and 43% ( n = 26) had Chronic Nonspecific Ulcerative Colitis. According to disease activity, 75% ( n = 45) were in the remission phase, 13% ( n = 8) had mild activity, and 9% ( n = 5) had moderate activity. Regarding vitamin D, 63% ( n = 38) had deficiency of this vitamin and 37% ( n = 22) presented sufficiency. With the association of serum vitamin D concentrations and disease activity, we observed statistical significance among the variables ( p = 0.005). Regarding biochemical exams, the majority of patients with fecal calprotectin elevation presented vitamin D deficiency ( p = 0.025). Statistically significant correlation between HSV and vitamin D ( p = 0.0001) was found. Conclusion According to the findings of this study, vitamin D deficiency is related to the clinical and laboratory activity of inflammatory bowel diseases.

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“…On the other hand, the lack of VD 3 is a major health problem [6,7]. According to clinical interpretations, the adequate blood level of VD 3 is 30-36 ng.ml -1 , and above 100-150 ng.ml -1 is considered as toxic [8].…”

Section: Introductionmentioning

confidence: 99%

Effect of HA Nanoparticles on Adsorption of Vitamin D3 on Super-Hydrophobic PA6 Nanofibrous Scaffold

Esfahani

Ghiyasi

2020

Matéria (Rio J.)

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Vitamin D 3 has significant roles in bone growth and the prevention of osteoporotic fractures. The present study investigated the effect of hydroxyapatite nanoparticles decoration onto polyamide-6 nanofibrous scaffold on adsorption behaviour of Vitamin D 3. To synthesize the nanofibrous scaffold, an electrospinning device was used, and the surface of the scaffold was characterized by scanning electron microscopy, energy dispersive spectrometry, Fourier transform infrared spectroscopy, and measurement of the water contact angle. The antibacterial activity test against E. coli and S. aureus bacteria indicated no such activity of pristine and hydroxyapatite decorated scaffold. The results demonstrated that a hydrophobic and high porous scaffold was formed, and hydroxyapatite nanoparticles were distributed inside the polyamide-6 nanofibers homogenously. Results showed that the hydroxyapatite nanoparticles improved the adsorption efficiency of polyamide-6 scaffold. It was found that the amount of adsorbed Vitamin D 3 molecules onto the polyamide-6/HA scaffold was rapid during the first hour of immersion (24.4 ng.cm-3), then declined over the next 3 h, and eventually reached a stable percentage of about 10.3 ng.cm-3. This phenomenon appears to be related to the high adsorption potential of porosities and the hydrophobic nanofibers during the first stage of immersion and non-occupied hydroxyapatite ceramic sites during the final stage of immersion.

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Hypovitaminosis D in patients with Crohn's disease

Cited by 4 publications

References 18 publications

Blood Dosage of Vitamin D in Pregnant Women and Association with Preeclampsia and Fetal Low Weight

Blood Dosage of Vitamin D in Pregnant Women and Association with Preeclampsia and Fetal Low Weight

Deficiency of vitamin D and its relation with clinical and laboratory activity of inflammatory bowel diseases

Effect of HA Nanoparticles on Adsorption of Vitamin D3 on Super-Hydrophobic PA6 Nanofibrous Scaffold

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