Hematological parameters, serum iron and vitamin B 12 levels in hospitalized Palestinian adult patients infected with Helicobacter pylori : a case–control study

Mwafy, Saleh; Afana, Wesam Mohammad

doi:10.1016/j.htct.2017.11.010

Cited by 27 publications

(37 citation statements)

References 21 publications

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“…However, these changes seem to be reversible after H pylori eradication, due to an improvement in serum iron and vitamin B12 levels. [ 14 ] A special attention has been given to iron refractory iron-deficiency anemia (IRIDA) in the past years, as H pylori infection eradication has been proved to improve the efficacy of iron supplementation in various pediatric studies evolving around this condition. Still, a recent review that summarized the findings of multiple studies and randomized control trials on this matter, underlined the need for higher quality, larger cohort researches to elucidate a possible association between iron deficiency anemia and H pylori infection in children.…”

Section: Introductionmentioning

confidence: 99%

Pediatric gastritis and its impact on hematologic parameters

Săsăran

Meliţ

Mocan³

et al. 2020

Medicine

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Non-invasive biomarkers, such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios, may predict inflammation in various disorders, including gastritis, according to recent data. Nevertheless, various studies reported an association between Helicobacter pylori ( H pylori ) and immune thrombocytopenia in both adults and pediatric patients. The objective of our study was to evaluate the impact of pediatric gastritis, caused or not by H pylori infection on erythrocytes, their parameters, thrombocytes, mean platelet volume, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). We performed a prospective, case–control study on 151 patients aged between 1 and 17 years who presented with chronic dyspeptic symptoms. An upper digestive endoscopy with gastric biopsies and a complete blood count was performed in each case. Control group consisted of 67 patients with normal histological findings, while the two study groups were divided into group 1— H pylori -induced gastritis (31 patients) and group 2—non- H pylori- induced gastritis (53 patients). Children from the rural area were more likely to develop both types of gastritis ( P < .01). No significant difference was found between either of the study groups and control group in terms of platelets, mean platelet volume, NLR and PLR ( P > .05). However, significantly higher values of lymphocytes were associated with non- H pylori -induced gastritis ( P < .01). Comparison of the two study groups did not reflect any significant differences in terms of hematological parameters. When assessing these constants in relation to gastritis severity, severe gastritis led to a compelling decrease in hemoglobin (Hb) and hematocrit (Htc) levels. The comparison of parameters between severe, moderate, and mild gastritis did not reveal any significant results. Childhood and adolescent gastritis does not produce a significant effect upon platelet counts, their mean volume, PLR or NLR, according to our study. An important increase in lymphocyte count might predict non- H pylori pediatric gastritis. Moreover, severe gastritis might result in an important decrease in Hb and Htc levels.

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Section: Introductionmentioning

confidence: 99%

Pediatric gastritis and its impact on hematologic parameters

Săsăran

Meliţ

Mocan³

et al. 2020

Medicine

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“…Moreover, they observed a significant correlation between administration of anti‐ H pylori treatment plus iron and improvement of hemoglobin ( P < .001), MCV ( P < .001), iron ( P < .001), and ferritin levels ( P < .001) . Mwafy et al investigated 150 H pylori ‐positive patients (18‐50 years old) and 150 matched controls for several hematologic parameters, and they found significantly lower levels of iron in infected patients compared to uninfected (71.6 ± 24.8 vs 80.1 ± 20.7 μg/dL) and similar results were obtained for vitamin B12 levels (262.5 ± 100 vs 378.2 ± 160.6 pg/mL) . Nevertheless, Tseng et al, who followed up 508 patients with IDA, did not report any significant difference on hemoglobin levels between those treated or not treated for H pylori after a 2‐year observation but that could also be due to the presence of intestinal metaplasia .…”

Section: Hematologic Diseasesmentioning

confidence: 99%

Review: Helicobacter pylori and extragastric diseases

2019

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In the last year, many studies have demonstrated a potential role of Helicobacter pylori in the pathogenic mechanisms of different extragastric diseases. While the role of H pylori in idiopathic thrombocytopenic purpura, idiopathic iron deficiency anemia, and vitamin B12 deficiency has already been demonstrated, there is growing evidence of other related conditions, especially cardiovascular, metabolic, and neurologic disorders, including neurodegenerative diseases. A summary of the results of the most relevant studies published over the last year on this attractive topic is presented in this review.

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“…A probable risk relationship between H. pylori infection and pernicious anemia was also suggested[ 47 ]. Case-control and prospective cohort studies have shown that patients with positive H. pylori had lower Vitamin B12 (Cobalamin) levels when compared to control groups[ 47 , 48 ]. In addition, when treated with triple therapy - clarithromycin, amoxicillin and omeprazole - to eradicate H. pylori , patients with previous pernicious anemia obtained satisfactory levels of Vitamin B12, with mean iron levels of 262.5 ± 100.0 pg/mL among H. pylori -positives against 378.2 ± 160.6 pg/mL in the group of H. pylori -negatives, representing a difference of 30.6% between those groups, with a P value of 0.001[ 48 ].…”

Section: Extragastric Manifestationsmentioning

confidence: 99%

“…Case-control and prospective cohort studies have shown that patients with positive H. pylori had lower Vitamin B12 (Cobalamin) levels when compared to control groups[ 47 , 48 ]. In addition, when treated with triple therapy - clarithromycin, amoxicillin and omeprazole - to eradicate H. pylori , patients with previous pernicious anemia obtained satisfactory levels of Vitamin B12, with mean iron levels of 262.5 ± 100.0 pg/mL among H. pylori -positives against 378.2 ± 160.6 pg/mL in the group of H. pylori -negatives, representing a difference of 30.6% between those groups, with a P value of 0.001[ 48 ]. Corroborating to the consolidation of this association, studies have shown that there is a decrease in Cobalamin levels in H. pylori positive patients regardless of gastric atrophy and dyspepsia[ 49 ].…”

Section: Extragastric Manifestationsmentioning

confidence: 99%

“…That is, there is no need for tissue damage and hemorrhagic processes for the onset of anemia due to infection by H. pylori [ 52 ]. When comparing H. pylori positive patients to the H. pylori negative ones, the first group had iron levels of 71.6 ± 24.8 μg/dL against 80.1 ± 20.7 μg/dL of the second one, a difference of 10,6%, with a t value of −3.206 and P value: 0.001[ 48 ].…”

Section: Extragastric Manifestationsmentioning

confidence: 99%

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Helicobacter pylori infection: Beyond gastric manifestations

Santos

Brito

Silva

et al. 2020

WJG

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Helicobacter pylori ( H. pylori ) is a bacterium that infects more than a half of world’s population. Although it is mainly related to the development of gastroduodenal diseases, several studies have shown that such infection may also influence the development and severity of various extragastric diseases. According to the current evidence, whereas this bacterium is a risk factor for some of these manifestations, it might play a protective role in other pathological conditions. In that context, when considered the gastrointestinal tract, H. pylori positivity have been related to Inflammatory Bowel Disease, Gastroesophageal Reflux Disease, Non-Alcoholic Fatty Liver Disease, Hepatic Carcinoma, Cholelithiasis, and Cholecystitis. Moreover, lower serum levels of iron and vitamin B12 have been found in patients with H. pylori infection, leading to the emergence of anemias in a portion of them. With regards to neurological manifestations, a growing number of studies have associated that bacterium with multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, and Guillain-Barré syndrome. Interestingly, the risk of developing cardiovascular disorders, such as atherosclerosis, is also influenced by the infection. Besides that, the H. pylori -associated inflammation may also lead to increased insulin resistance, leading to a higher risk of diabetes mellitus among infected individuals. Finally, the occurrence of dermatological and ophthalmic disorders have also been related to that microorganism. In this sense, this minireview aims to gather the main studies associating H. pylori infection with extragastric conditions, and also to explore the main mechanisms that may explain the role of H. pylori in those diseases.

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Hematological parameters, serum iron and vitamin B 12 levels in hospitalized Palestinian adult patients infected with Helicobacter pylori : a case–control study

Cited by 27 publications

References 21 publications

Pediatric gastritis and its impact on hematologic parameters

Pediatric gastritis and its impact on hematologic parameters

Review: Helicobacter pylori and extragastric diseases

Helicobacter pylori infection: Beyond gastric manifestations

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