Review: <i>Helicobacter pylori</i> and extragastric diseases

Franceschi, Francesco; Covino, Marcello; Baudron, Claire Roubaud

doi:10.1111/hel.12636

Cited by 53 publications

(38 citation statements)

References 70 publications

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“…[ 27 ] However, it produces a systemic response, mediated by pro-inflammatory cytokines, causing systemic manifestations, even in pediatric patients. [ 28 , 29 ] Its oncoprotein CagA has been associated with both carcinogenesis [ 30 ] and hematologic disorders, including thrombocytopenia. [ 31 ] Due to its molecular mimicry, this protein can cross-react with platelet-associated immunoglobulin G antibodies, therefore triggering autoimmune-induced destruction of platelets.…”

Section: Discussionmentioning

confidence: 99%

Pediatric gastritis and its impact on hematologic parameters

Săsăran

Meliţ

Mocan³

et al. 2020

Medicine

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Non-invasive biomarkers, such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios, may predict inflammation in various disorders, including gastritis, according to recent data. Nevertheless, various studies reported an association between Helicobacter pylori ( H pylori ) and immune thrombocytopenia in both adults and pediatric patients. The objective of our study was to evaluate the impact of pediatric gastritis, caused or not by H pylori infection on erythrocytes, their parameters, thrombocytes, mean platelet volume, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). We performed a prospective, case–control study on 151 patients aged between 1 and 17 years who presented with chronic dyspeptic symptoms. An upper digestive endoscopy with gastric biopsies and a complete blood count was performed in each case. Control group consisted of 67 patients with normal histological findings, while the two study groups were divided into group 1— H pylori -induced gastritis (31 patients) and group 2—non- H pylori- induced gastritis (53 patients). Children from the rural area were more likely to develop both types of gastritis ( P < .01). No significant difference was found between either of the study groups and control group in terms of platelets, mean platelet volume, NLR and PLR ( P > .05). However, significantly higher values of lymphocytes were associated with non- H pylori -induced gastritis ( P < .01). Comparison of the two study groups did not reflect any significant differences in terms of hematological parameters. When assessing these constants in relation to gastritis severity, severe gastritis led to a compelling decrease in hemoglobin (Hb) and hematocrit (Htc) levels. The comparison of parameters between severe, moderate, and mild gastritis did not reveal any significant results. Childhood and adolescent gastritis does not produce a significant effect upon platelet counts, their mean volume, PLR or NLR, according to our study. An important increase in lymphocyte count might predict non- H pylori pediatric gastritis. Moreover, severe gastritis might result in an important decrease in Hb and Htc levels.

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Section: Discussionmentioning

confidence: 99%

Pediatric gastritis and its impact on hematologic parameters

Săsăran

Meliţ

Mocan³

et al. 2020

Medicine

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“…A possible association between HPI and over 50 systemic diseases has been described. In recent years numerous reviews focused on this topic [ 11 , 13 , 14 , 68 , 79 , 331 , 332 , 333 , 334 , 335 , 336 , 337 , 338 , 339 , 340 , 341 , 342 , 343 , 344 , 345 , 346 ]. Most of HPI–linked extra-gastroduodenal chronic diseases and disorders as well as treatments used for are known to increase risk of OP, falls and OFs, especially in the elderly [ 317 , 347 , 348 , 349 ].…”

Section: Hpi-associated Chronic Extra-gastroduodenal Diseases Medmentioning

confidence: 99%

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

Fisher

Smith

2020

JCM

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Osteoporosis (OP) and osteoporotic fractures (OFs) are common multifactorial and heterogenic disorders of increasing incidence. Helicobacter pylori (H.p.) colonizes the stomach approximately in half of the world’s population, causes gastroduodenal diseases and is prevalent in numerous extra-digestive diseases known to be associated with OP/OF. The studies regarding relationship between H.p. infection (HPI) and OP/OFs are inconsistent. The current review summarizes the relevant literature on the potential role of HPI in OP, falls and OFs and highlights the reasons for controversies in the publications. In the first section, after a brief overview of HPI biological features, we analyze the studies evaluating the association of HPI and bone status. The second part includes data on the prevalence of OP/OFs in HPI-induced gastroduodenal diseases (peptic ulcer, chronic/atrophic gastritis and cancer) and the effects of acid-suppressive drugs. In the next section, we discuss the possible contribution of HPI-associated extra-digestive diseases and medications to OP/OF, focusing on conditions affecting both bone homeostasis and predisposing to falls. In the last section, we describe clinical implications of accumulated data on HPI as a co-factor of OP/OF and present a feasible five-step algorithm for OP/OF risk assessment and management in regard to HPI, emphasizing the importance of an integrative (but differentiated) holistic approach. Increased awareness about the consequences of HPI linked to OP/OF can aid early detection and management. Further research on the HPI–OP/OF relationship is needed to close current knowledge gaps and improve clinical management of both OP/OF and HPI-related disorders.

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“…It is shown that H. pylori has a large spectrum of both metabolic and non-metabolic extra-gastric manifestations. A striking study by Isave et al demonstrated the colonization of H. pylori in the hepatobiliary system of cirrhosis patients with a frequency of 50% [14]. Their findings support the studies that were pointed out toward the H. pylori infection and hepatocellular carcinoma [15].…”

Section: Discussionmentioning

confidence: 53%

Evaluation of Helicobacter pylori Infection, Neutrophil–Lymphocyte Ratio and Platelet–Lymphocyte Ratio in Dyspeptic Patients

Böyük

Saydan

Maviş

et al. 2020

Gastroenterology Insights

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Recent studies have shown a correlation between Helicobacter pylori (H. Pylori) infection and the neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). The aim of this study was to investigate the relationship between H. Pylori infection and hematimetric indices in patients with dyspepsia symptoms. Overall, 448 patients who underwent gastroscopy were analyzed retrospectively. Histopathological evaluation of biopsies according to H. pylori presence was classified as H. Pylori positive and negative groups, which are analyzed in relation with hematimetric indices. NLR and PLR measurements did not show a statistically significant difference between H. pylori negative and positive groups (p > 0.05). NLR revealed a negative correlation between hemoglobin (HGB), iron, and ferritin measurements in the correlation analysis of the H. Pylori positive group (r = −0.133, p = 0.031; r = −0.270, p = 0.002; r = −0.162, p = 0.032). Again, with PLR, there was a negative correlation between HGB, mean corpuscular volume (MCV), iron, and ferritin measurements (r = −0.310, p = 0.001, r = −0.187, p = 0.002, r = −0.335, p = 0.001; r = −0.290; p = 0.001). The results of our study do not reveal an association between H. pylori presence and inflammatory response, which is evaluated by NLR and PLR measurements in patients with dyspepsia. However, low serum iron and ferritin values of H. pylori-positive patients suggest the effect of H. pylori on iron metabolism.

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Review: Helicobacter pylori and extragastric diseases

Cited by 53 publications

References 70 publications

Pediatric gastritis and its impact on hematologic parameters

Pediatric gastritis and its impact on hematologic parameters

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

Evaluation of Helicobacter pylori Infection, Neutrophil–Lymphocyte Ratio and Platelet–Lymphocyte Ratio in Dyspeptic Patients

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