A new tricyclic abietane diterpenoid from Salvia chloroleuca and evaluation of cytotoxic and apoptotic activities

Therapeutic benefits of Salvia species: A focus on cancer and viral infection

“… [ 22 ] PDE sub-fractions of methanol extracts of S. chloroleuca roots 25–200 μg/ml MCF-7 and PC-3 Reduced viability of MCF-7 and PC-3 cell lines, with IC 50 values ranging from 24.19 to 47.15 μg/ml. PDE sub-fractions induced apoptosis in PC-3 cells with DCM sub-fraction increasing the Bax/Bcl-2 ratio by 650% compared to negative control, and cleaving PARP [ 64 ] Petroleum ether sub-fractions of methanol extracts S. atropatana roots 2.5–200 μg/ml PC-3, MCF-7 and MDA-MB-231 Reduced proliferation of PC-3 (IC 50 = 8.73 μg/ml), MCF-7 (IC 50 = 32.40 μg/ml) and MDA-MB-231 (IC 50 = 77.65 μg/ml) by cleaving PARP. [ 69 ] n -hexane sub-fraction of methanol extracts of aerial parts of S. macrosiphon N.D A549, MCF-7, MDA-MB-231 and normal HDF Cytotoxic against A549, MCF-7, MDA-MB-231 and HDF with IC 50 values of 20.89, 10.24, 20.98 and 26.90 μg/ml, respectively.…”

“…chorassanica roots, stem and leaves reduced the proliferation of AGS and MKN-45 cancer cells, with highest cytotoxicity observed when AGS cells were treated with the roots extract (IC 50 = 9.262 μg/ml) [ 22 ]. The petroleum ether, dichloromethane and ethyl acetate (PDE) sub-fractions of methanol extracts of S. chloroleuca roots showed cytotoxicity against human breast adenocarcinoma (MCF-7) and prostate (PC-3) cell lines, with IC 50 values ranging from 24.19 to 47.15 μg/ml, which were however, less active than the reference anticancer agent, DRX (IC 50 = 2.78 and 2.49 μg/ml for MCF-7 and PC-3, respectively) [ 64 ]. Notably, the PDE sub-fractions induced apoptosis in PC-3 cells, as indicated by increase in sub-G1 peaks in flow cytometry histograms; with dichloromethane (DCM) sub-fraction achieving this by increasing the Bax/Bcl-2 ratio by 650% compared to negative control, and cleaving poly (ADP-ribose) polymerase (PARP).…”

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

“…Arguably, the most important class of chemicals produced by the Lamiaceae family is the terpenoids; of these, the most numerous subclass of compounds with confirmed anticancer properties is that of the diterpenoids. Many possess pro-apoptotic properties, including 3-acetoxylteuvincenone from Ajuga ovalifolia whole plants [ 263 ], sahandone and sahandol II from Salvia chloroleuca roots [ 264 ], acetyl-macrocalin B from Isodon sylvatica [ 265 ], parvifloron D from Plectranthu ecklonii [ 227 ], and 7β-acetoxy-20-hydroxy-19,20-epoxyroyleanone from Salvia corrugate shoots [ 266 ]. 3-acetoxylteuvincenone activates Src homology phosphotyrosine phosphatase 2 (SHP2) and induces extracellular signal-regulated kinase (ERK) 1/2 and Akt pathways in A549 cells [ 263 ].…”

“…Moreover, SNP2 has been implicated in the activation of ERK 1/2, a member of mitogen-activated protein kinases (MAPKs) that restored the levels of c-Myc [ 268 ]. Sahandone and sahandol II change the ratio of Bax/Bcl-2 apoptotic proteins and activate PARP in the MCF-7, LNCaP, and PC-3 cell lines [ 264 ]. Acetyl-macrocalin B induces apoptosis in an ROS-dependent manner in A549 cells and then upregulates the p38 MAPK signaling pathway that mediates caspase-9 release.…”

Sideritis perfoliata inhibits cell proliferation, induces apoptosis and exhibits cellular antioxidant activity in cervical cancer cells

“…In parallel with increasing cancer cases, the discovery of new natural agents have been gained importance to treatment them. Especially, plants belonging to Lamiaceae are used as important sources for this purpose (Pudziuvelyte et al, 2017;Shakeri et al, 2019;Balusamy et al, 2018). Many phytochemical agents in this genus are used in the treatment of many diseases, including cancer for a long time.…”