Phytochemistry and antimicrobial activity of Campomanesia adamantium

Sá, Stone de; Chaul, Luíza Toubas; Alves, Virgínia Farias; Fiuza, Tatiana de Sousa; Tresvenzol, Leonice Manrique Faustino; Vaz, Boniek G.; Ferri, Pedro Henrique; Borges, Leonardo L.; Paula, José Realino de

doi:10.1016/j.bjp.2018.02.008

Cited by 22 publications

(24 citation statements)

References 41 publications

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“…Biomonitored phytochemical research aims to identify which substances are responsible for specific biological activities [37,38,39]. Biomonitored research involves studies across several knowledge areas to identify the bioactive compounds of interest [40].…”

Section: Discussionmentioning

confidence: 99%

Larvicidal Compounds Extracted from Helicteres velutina K. Schum (Sterculiaceae) Evaluated against Aedes aegypti L.

et al. 2019

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Helicteres velutina K. Schum (Sterculiaceae), a member of Malvaceae sensu lato, is a Brazilian endemic plant that has been used by the indigenous tribe Pankarare as an insect repellent. A previous study has reported the isolation of terpenoids, flavonoids and pheophytins, in addition to the larvicidal activity of crude H. velutina extracts derived from the aerial components (leaves, branches/twigs, and flowers). The present study reports the biomonitoring of the effects of fractions and isolated compounds derived from H. velutina against A. aegypti fourth instar larvae. A crude ethanol extract was submitted to liquid–liquid extraction with hexane, dichloromethane, ethyl acetate and n-butanol to obtain their respective fractions. Larvicidal evaluations of the fractions were performed, and the hexane and dichloromethane fractions exhibited greater activities than the other fractions, with LC50 (50% lethal concentration) values of 3.88 and 5.80 mg/mL, respectively. The phytochemical study of these fractions resulted in the isolation and identification of 17 compounds. The molecules were subjected to a virtual screening protocol, and five molecules presented potential larvicidal activity after analyses of their applicability domains. When molecular docking was analysed, only three of these compounds showed an ability to bind with sterol carrier protein-2 (1PZ4), a protein found in the larval intestine. The compounds tiliroside and 7,4′-di-O-methyl-8-O-sulphate flavone showed in vitro larvicidal activity, with LC50 values of 0.275 mg/mL after 72 h and 0.182 mg/mL after 24 h of exposure, respectively. This is the first study to demonstrate the larvicidal activity of sulphated flavonoids against A. aegypti. Our results showed that the presence of the OSO3H group attached to C-8 of the flavonoid was crucial to the larvicidal activity. This research supports the traditional use of H. velutina as an alternative insecticide for the control of A. aegypti, which is a vector for severe arboviruses, such as dengue and chikungunya.

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Section: Discussionmentioning

confidence: 99%

Larvicidal Compounds Extracted from Helicteres velutina K. Schum (Sterculiaceae) Evaluated against Aedes aegypti L.

et al. 2019

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“…Its fruit can be consumed in natura or in the form of juice, ice cream, popsicles, candy, or liqueur (Bardiviesso, Maruyama, Reis, Modesto, & Rezende, 2011). In addition, studies have demonstrated the species to have medicinal properties including anti-inflammatory, antihyperalgesic and antidepressant actions (Souza et al, 2014), antimicrobial (Sá et al, 2018), as well as antidiarrheal (Lescano et al, 2016) and antileukemic activity, thus demonstrating therapeutic potential for diseases associated with the proliferation of tumor cells (Campos et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Embryogenic potential of the callus of gabirobeira, Campomanesia adamantium (Cambess) O. Berg

Rossato

Schumacher

Netto

et al. 2019

Acta Sci. Biol. Sci.

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Campomanesia adamantium is a native plant species of Brazilian Cerrado with diverse economic potential and great medicinal importance. Its sexual propagation is impaired by the recalcitrance of its seeds, which prevents effective and profitable propagation. With the purpose of establishing commercial crops and minimizing the extractive use of vegetal resources, the aim of the present study was to induce embryogenic calli in nodal segments of gabirobeira, and to determine and characterize their embryogenic phase through the establishment of a growth curve based on cellular characteristics. Calli were induced using nodal segments inoculated in WPM culture medium without the addition of hormones (control) and with different concentrations of 2,4-D, IAA, IBA, NAA or picloram. Cytochemical and SEM analyses revealed cellular characteristics of the formation of meristematic centers that indicated 4.14 μM of picloram to be the best treatment for induction of embryogenic calli, and demonstrating their embryogenic potential. The treatment was used to establish a callus growth curve, from which it was inferred that calli should be transferred to new culture media on the 28th day to maintain cell viability

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“…Gabiroba fruit is characterized as rounded berries ranging from 1 to 2 cm in diameter, with yellow-green color and sweet taste; gabiroba fruiting occurs from September to November and could eventually extend until February (Oliveira, Rossi, & Barros, 2011). The fruit and leaves are used to combat influenza, since the plant is rich in vitamin C, and the shells are indicated in the treatment antiinflammatory, anti-diarrhoeal and urinary antiseptic activities, since the shells contain astringent substances (Oliveira et al, 2011;Sá et al, 2018). However, little is known about the physiology and conservation of gabiroba fruit.…”

Section: Introductionmentioning

confidence: 99%

Post-harvest quality of Campomanesia adamantium (Cambess.) O. Berg. in function of storage temperature

Santos¹,

Costa²,

Megguer³

et al. 2020

Acta Sci Technol

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Brazil has a large variety of native and exotic fruit species, including the gabiroba, which can be sources of income for the population. The objective of this study was to evaluate the post-harvest behavior of gabiroba fruit by maturity stage and storage temperature. The fruits were divided into two lots and stored at temperatures of 6, 12, 24 and 30°C. The first batch was used for the physical and chemical analysis of acidity, soluble solids, firmness, percentage of green color, and visual analysis; this batch was composed of green and yellow-green fruit. The second lot was intended for breath analysis, composed of green, yellow-green, and yellow fruits. The experiment was conducted in a completely randomized design with five replications. Data were analyzed using descriptive statistics. Considering the evaluated characteristics, the gabiroba soluble solid/titratable acidity ratio values should be approximately 4.0 for the fruits to be considered acceptable for consumption. For the preservation of the post-harvest quality of gabiroba, it is indicated that the harvest is carried out at the green stage of maturation and that they are stored at a temperature of 6°C. The highest respiratory rates were observed in fruits harvested at the yellow stage, not being recommended its storage.

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Phytochemistry and antimicrobial activity of Campomanesia adamantium

Cited by 22 publications

References 41 publications

Larvicidal Compounds Extracted from Helicteres velutina K. Schum (Sterculiaceae) Evaluated against Aedes aegypti L.

Larvicidal Compounds Extracted from Helicteres velutina K. Schum (Sterculiaceae) Evaluated against Aedes aegypti L.

Embryogenic potential of the callus of gabirobeira, Campomanesia adamantium (Cambess) O. Berg

Post-harvest quality of Campomanesia adamantium (Cambess.) O. Berg. in function of storage temperature

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