Antitussive and expectorant properties of growing and fallen leaves of loquat ( Eriobotrya japonica )

Wu, Yaohong; Jian, Tunyu; Han, Li; Ding, Xiaoqin; Zuo, Ya‐Gang; Ren, Bingru; Chen, Jian; Li, Weilin

doi:10.1016/j.bjp.2018.02.006

Cited by 20 publications

(7 citation statements)

References 17 publications

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“…In our previous study, Loquat Leaf exhibited a therapeutic effect on high-fat-diet induced NAFLD by regulating lipid accumulation and oxidative stress [ 19 ]. Flavonoids (about 3% in total extract) containing quercetin and kaemferol as the parent nucleus are main active components in Loquat Leaf [ 24 , 30 ]. These flavonoids not only have benefits on glucose metabolism, lipid metabolism, and NAFLD, but also exhibit anti-oxidative activity [ 23 , 24 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Loquat Leaf Flavonoids in PM2.5-Induced Non-Alcoholic Fatty Liver Disease via Regulation of IRs-1/Akt and CYP2E1/JNK Pathways

Jian

Ding

et al. 2018

IJMS

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Ambient air particulate matter (PM) represents a class of heterogeneous substances present in polluted air, which contains many harmful components. Exposure to ambient particulate matter in fine rages (PM2.5) is associated with non-alcoholic fatty liver disease (NAFLD). Loquat Leaf possesses pharmacological actions on NAFLD. As the main biological active ingredients, the potential therapeutic role of total flavonoids (TF) isolated from Loquat Leaf in PM2.5-induced NAFLD model remains unclear. The present study was designed to explore the hepatoprotective effect of TF in PM2.5-induced NAFLD mice with its related mechanisms of action. Mice were exposed to PM2.5 to induce NAFLD, and body weight, the ratio of liver to body weight, and blood lipids increased significantly compared with the control group. It was found that TF significantly reduced the above parameters in PM2.5-induced NAFLD mice. TF treatment alleviated oxidative stress by preventing the accumulation of oxidative product malondialdehyde (MDA) and by strengthening the anti-oxidative capacity of superoxide dismutase (SOD). TF was also found to reduce the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity in the PM2.5 group. In addition, TF repaired the PM2.5-induced decline of insulin receptor substrate-1 (IRs-1) and protein kinase B (Akt) phosphorylation. Meanwhile, the data showed TF suppressed the expression of cytochrome P450 2E1(CYP2E1) and the phosphorylation of c-jun N-terminal kinase (JNK) in PM2.5-induced NAFLD. Taken together, these findings show that TF alleviate PM2.5-induced NAFLD via regulation of IRs-1/Akt and CYP2E1/JNK pathways, which may have potential for further development as novel therapeutic agents for NAFLD.

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Loquat Leaf Flavonoids in PM2.5-Induced Non-Alcoholic Fatty Liver Disease via Regulation of IRs-1/Akt and CYP2E1/JNK Pathways

Jian

Ding

et al. 2018

IJMS

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“…TA was extracted from loquat leaf by a previously described method with some minor alterations according to the study of Wu et al [24]. In short, dried powder (1000 g) of loquat leaf was extracted with 95% ethanol (W:V (g:mL) = 1:5) twice (2 h each time) in a 90 • C water bath.…”

Section: Isolation Of Ta From Loquat Leafmentioning

confidence: 99%

Triterpene Acids of Loquat Leaf Improve Inflammation in Cigarette Smoking Induced COPD by Regulating AMPK/Nrf2 and NFκB Pathways

Jian

Ding

et al. 2020

Nutrients

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Cigarette smoking (CS) is believed to be an important inducement in the pathological development of chronic obstructive pulmonary disease (COPD), a progressive lung disease. Loquat is an Asian evergreen tree commonly cultivated for its fruit. Its leaf has long been used as an important material for both functional and medicinal applications in the treatment of lung disease in China and Japan. As the principal functional components of loquat leaf, triterpene acids (TAs) have shown notable anti-inflammatory activity. However, their protective activity and underlying action of mechanism on CS-induced COPD inflammation are not yet well understood. In the present study, male C57BL/6 mice were challenged with CS for 12 weeks, and from the seventh week of CS exposure, mice were fed with TAs (50 and 100 mg/kg) for 6 weeks to figure out the therapeutic effect and molecular mechanism of TAs in CS-induced COPD inflammation. The results demonstrate that TA suppressed the lung histological changes in CS-exposed mice, as evidenced by the diminished generation of pro-inflammatory cytokines, including interleukin 1β (IL-1β), IL-2, IL-6, and tumor necrosis factor α (TNF-α). Moreover, TA treatment significantly inhibited the malondialdehyde (MDA) level and increased superoxide dismutase (SOD) activity. In addition, TAs increased the phosphorylation of AMP-activated protein kinase (AMPK) and nuclear factor erythroid-2-related factor-2 (Nrf2) expression level, while inhibiting phosphorylation of nuclear factor kappa B (NFκB) and inducible nitric oxide synthase (iNOS) expression in CS-induced COPD. In summary, our study reveals a protective effect and putative mechanism of TA action involving the inhibition of inflammation by regulating AMPK/Nrf2 and NFκB pathways. Our findings suggest that TAs could be considered as a promising functional material for treating CS-induced COPD.

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“…Ekstrak dengan kandungan flavonoid yang lebih tinggi menunjukkan aktivitas antitusif yang lebih baik. 14 Penelitian lain menyatakan bahwa fraksi polar herba meniran dengan dosis 160 mg/ kgBB pada hewan uji marmut menunjukkan nilai antitusif paling efektif yaitu 65,87% dibanding penggunaannya dengan dosis lain yang lebih rendah. Kandungan flavonoid yang terkandung dalam fraksi herba meniran diduga memiliki peran dalam aktivitas antitusif.…”

Section: Pembahasanunclassified

AKTIVITAS ANTITUSIF KOMBINASI EKSTRAK ETANOL JAHE MERAH (Zingiber officinale var. rubrum) DAN DAUN UNGU (Graptophyllum pictum) PADA MARMUT (Cavia porcellus)

Umami

Mutiah

Annisa

2020

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Batuk sebagai sebuah sistem perlindungan dengan cara mengeluarkan benda asing pada saluran pernapasan manusia yang bisa menyebabkan infeksi. Perlu dilakukan penelitian terhadap pemanfaatan tanaman sebagai obat yang digunakan untuk mengatasi batuk. Hal tersebut dikarenakan tanaman obat memiliki efek samping minim daripada obat buatan. Jahe merah (Zingiber officinale var. rubrum) serta daun ungu (Graptophylum pictum) telah dimanfaatkan penggunaannya dengan cara tradisional dalam mengatasi batuk. Tujuan penelitian ini yaitu mendapatkan pengetahuan mengenai aktivitas antitusif serta perbandingan optimal kombinasi dari ekstrak etanol 96% jahe merah serta ekstrak etanol 96% daun ungu. Uji aktivitas antitusif dilakukan dengan menilai persentase supresi batuk melalui induksi larutan asam sitrat 7,5% pada hewan coba marmut betina sebanyak 28 ekor dibagikan menjadi tujuh kelompok perlakuan di antaranya perlakuan dengan pemberian CMC-Na (kontrol negatif), kodein 10 mg/kg BB (kontrol positif), dosis tunggal 250 mg/kg BB dari ekstrak etanol 96% jahe merah serta daun ungu, dosis kombinasi ekstrak etanol 96% jahe merah serta daun ungu dengan perbandingan kombinasi 1:1, 0,5:1 dan 1:0,5 selama 5 hari. Penelitian menunjukkan hasil bahwa ekstrak etanol 96% jahe merah serta daun ungu pada dosis tunggal maupun kombinasinya memiliki aktivitas antitusif yang mampu meningkatkan supresi batuk melalui hewan percobaan yaitu marmut. Perbandingan hasil kombinasi ekstrak etanol 96% jahe merah serta ekstrak etanol 96% daun ungu yang optimal adalah 1:0,5 dengan persentase supresi batuk sebesar 73,00 %. Kata kunci: antitusif, asam sitrat 7,5%, daun ungu (Graptophylum pictum), jahe merah (Zingiber officinale var. rubrum).

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Antitussive and expectorant properties of growing and fallen leaves of loquat ( Eriobotrya japonica )

Cited by 20 publications

References 17 publications

Hepatoprotective Effect of Loquat Leaf Flavonoids in PM2.5-Induced Non-Alcoholic Fatty Liver Disease via Regulation of IRs-1/Akt and CYP2E1/JNK Pathways

Hepatoprotective Effect of Loquat Leaf Flavonoids in PM2.5-Induced Non-Alcoholic Fatty Liver Disease via Regulation of IRs-1/Akt and CYP2E1/JNK Pathways

Triterpene Acids of Loquat Leaf Improve Inflammation in Cigarette Smoking Induced COPD by Regulating AMPK/Nrf2 and NFκB Pathways

AKTIVITAS ANTITUSIF KOMBINASI EKSTRAK ETANOL JAHE MERAH (Zingiber officinale var. rubrum) DAN DAUN UNGU (Graptophyllum pictum) PADA MARMUT (Cavia porcellus)

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