In vivo anti-arthritic and antioxidant effects from the standardized ethanolic extract of Moussonia deppeana

Gutiérrez-Rebolledo, Gabriel Alfonso; Garduño‐Siciliano, Leticia; Chávez-Rueda, Adriana Karina; Siordia-Reyes, Alicia Georgina; Zamilpa, Alejandro; Jiménez-Arellanes, María Adelina

doi:10.1016/j.bjp.2018.02.004

Cited by 13 publications

(12 citation statements)

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“…Phenolic compounds, including the flavonoids, are bioactive secondary metabolites known for a wide range of health benefits [ 13 , 20 ]. They have considerable antioxidant activity, as demonstrated in several in vitro and in vivo assay systems [ 13 , 21 , 22 ]. Multiple electron-donating phenolic hydroxyl groups in the flavonoid and phenylethanoid glycosides and resonance stabilization of the radicals explain this high radical scavenging activity [ 23 , 24 ].…”

Section: Resultsmentioning

confidence: 99%

Insecticidal Activity and Free Radical Scavenging Properties of Isolated Phytoconstituents from the Saudi Plant Nuxia oppositifolia (Hochst.)

et al. 2021

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Chromatographic purification of the alcoholic extract from the aerial parts of the Saudi plant Nuxia oppositifolia (Hochst.), Benth., resulted in five isolated phenolic compounds. Two flavones, hispidulin (1) and jaceosidin (2), and the phenylethanoid glycosides, verbascoside (3), isoverbascoside (4), and conandroside (5), were identified and their chemical structures were determined by spectroscopic analyses. The insecticidal activity of compounds 1 and 2, in addition to 11 compounds isolated in a previous research (6–16), was evaluated against the Yellow Fever mosquito, Aedes aegypti. Four compounds displayed adulticidal activity with LD50 values of 2–2.3 μg/mosquito. Free radical scavenging properties of the plant extracts and compounds (1–5) were evaluated by measuring the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonate radical cation (ABTS•+) scavenging activity. All compounds exhibited notable activity, compared with the positive control, l-Ascorbic acid. This study suggests that N. oppositifolia could be a promising source of secondary metabolites, some with lethal adulticidal effect against Ae. aegypti.

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Section: Resultsmentioning

confidence: 99%

Insecticidal Activity and Free Radical Scavenging Properties of Isolated Phytoconstituents from the Saudi Plant Nuxia oppositifolia (Hochst.)

et al. 2021

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“…This assay was carried out according to that previously described (Gutiérrez-Rebolledo et al [ 10 , 11 ]), with modifications. All groups (n = 7) were injected subcutaneously with 25 μ L of CFA in right hind paw on days zero and 14 (reinjection).…”

Section: Methodsmentioning

confidence: 99%

Hepatoprotective and Anti‐Inflammatory Activities of the Cnidoscolus chayamansa (Mc Vaugh) Leaf Extract in Chronic Models

Pérez-González

Siordia-Reyes

Damián-Nava

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Previous report described that CHCl3:MeOH extract of C. chayamansa leaves and pure compounds (moretenol, moretenyl acetate, kaempferol-3,7-dimethyl ether, and 5-hydroxy-7-3′,4′-trimethoxyflavanone) showed important topical and systemic anti-inflammatory activity in acute model, as well as in vitro antimycobacterial and antiprotozoal activities. In this paper, we describe the in vivo hepatoprotective and anti-inflammatory effects of the CHCl3:MeOH extract in chronic model and the isolation of additional compounds (moretenone and lupeol acetate). The hepatoprotective activity was determined at 39 days using Balb/c mice with liver damage induced with an antitubercular drug (RIF/INH/PZA). The anti-inflammatory activity was evaluated in a chronic model induced with CFA and in two acute models (TPA and carrageenan). In addition, moretenone and lupeol acetate were isolated and identified by spectroscopic data. Lupeol acetate is a main compound present in fractions 14-42, and this fraction was the majority fraction from the extract; from this moretenone was obtained. In animals with liver damage, the extract at 200 and 400 mg/kg induced better body weight gain with respect to positive control (Silymarin); in addition, the mice that received the extract at 200 mg/kg and Silymarin exhibited slight steatosis; however, the animals' livers at 400 mg/kg did not show steatosis. The extract and fractions 14-42 showed a good anti-inflammatory activity by TPA model (DE50 = 1.58 and 1.48 mg/ear) and by carrageenan model (DE50 = 351.53 and 50.11 mg/kg). In the chronic inflammatory test, the extract at three doses revealed a similar effect to that of phenylbutazone, although the body weight gain was better in animals that received the extract at 900 mg/kg. Conclusion. The CHCl3:MeOH extract showed significant anti-inflammatory and good hepatoprotective effect on chronic models. The fraction containing moretenone and lupeol acetate as main compounds was more active than extract in both acute models of inflammation.

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“…Finally, the edema of that paw was measured again 1 h, 2 h, 3 h, 4 h,and 5 h, 6 h (for carrageenan and histamine) later using the digital micrometer. These determined edema outcome values were used to calculate the percentage of inhibition of the edema (% INH) according to the formula used by Meshram et al and Gutiérrez-Rebolledo et al [14,15]. Inflammation curative activity of the extract Edema was induced in each rat 1 h (egg albumin) or 2 h (carrageenan) by injecting either 0.1 mL of carrageenan (1%) solution or 0.1 mL of fresh egg albumin under the paw of the right hind leg before the gavage with AEJf or normal saline.…”

Section: Inflammation Preventive Activity Of the Extractmentioning

confidence: 99%

Anti-Inflammatory Effects of an Aqueous Extract of Justicia Flava (Forsk) Vahl (Acanthaceae) in Rats

Wenceslas

Frédéric

Léandre

et al. 2021

Asian J Pharm Clin Res

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Objective: Justicia flava is a plant commonly used in traditional medicine for the treatment of frictions, convulsions, body aches, pains, and fever. The aim of this study was to determine the anti-inflammatory properties of an aqueous extract of J. flava (AEJf) in rats. Methods: Thus, 36 rats were divided into six groups of six rats each for each test. Acute anti-inflammatory activity was evaluated by induction of plantar edema following injections of egg albumin, carrageenan, or histamine. AEJf and aspirin (100 mg/kg bw) were orally administered to rats with doses ranged from 62.5 to 500 mg/kg bw before (preventive study) and after (curative study) the induction of edema. The rat’s paw edema was measured using a digital caliper thereafter. For a sub-chronic anti-inflammatory activity, sterilized cotton pellets (20±0.5 mg) were implanted in the anterior dorsal region for granuloma formation. Animals received the different doses of AEJf (62.5–500 mg/kg bw) for 7 days and on the 8th day, cotton pellets were removed and weighed, dried, and weighed again. Results: The results of the oral administration of AEJf at doses of 62.5, 125, 250, and 500 mg/kg bw to rats showed similar acute anti-inflammatory properties such as aspirin (100 mg/kg bw) on carrageenan (1%), fresh egg albumin, and histamine injection-induced rats’ paw edema. AEJf caused 77.63% (preventive study) and 28.1% (curative study) inhibitions of carrageenan (1%) solution-induced paw edema and 61% (preventive study) and 29.62% (curative study) inhibitions of fresh egg albumin-induced paw edema. AEJf also inhibited histamine-induced edema (1 mg/mL) by 83.67% compared to the control group. AEJf significantly reduced the weight of granuloma tissue elicited by the insertion of sterile cotton pellets from 34.53 to 46.98% for wet cottons and from 45.73 to 59.45% for dry cottons. Conclusion: AEJf possessed anti-inflammatory activity on acute and sub-chronic inflammations in rats.

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In vivo anti-arthritic and antioxidant effects from the standardized ethanolic extract of Moussonia deppeana

Cited by 13 publications

References 54 publications

Insecticidal Activity and Free Radical Scavenging Properties of Isolated Phytoconstituents from the Saudi Plant Nuxia oppositifolia (Hochst.)

Insecticidal Activity and Free Radical Scavenging Properties of Isolated Phytoconstituents from the Saudi Plant Nuxia oppositifolia (Hochst.)

Hepatoprotective and Anti‐Inflammatory Activities of the Cnidoscolus chayamansa (Mc Vaugh) Leaf Extract in Chronic Models

Anti-Inflammatory Effects of an Aqueous Extract of Justicia Flava (Forsk) Vahl (Acanthaceae) in Rats

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