Evaluation of anxiolytic-like effect of 7-epiclusianone isolated from Garcinia brasiliensis in mice

Veloso, Clarice de Carvalho; Silva, Mayara Bueno da; Megda, Marianne de Oliveira; Santos, Marcelo H. dos; Giusti‐Paiva, Alexandre; Vilela, Fabiana C.

doi:10.1016/j.bjp.2018.01.009

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…Similar results were reported in other studies. [31][32][33][34] Elevated plus maze test was carried out to evaluate anxiolytic activity of medicinal plants. It operates based on the rodents" natural dislike for elevated open space and their interest to walk around their environment in search for food and shelter.…”

Section: Resultsmentioning

confidence: 99%

“…The outcome signified anxiolytic activity and is comparable to the outcome of other investigations. [31][32][33][34][35][36][37][38][39] The staircase test experiment is primarily designed to test for both anxiolytic and sedative properties of a medicinal plant. Parameters such as decreased in frequency of rearing without affecting steps climbing signify anxiolytic activity.…”

Section: Resultsmentioning

confidence: 99%

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Anxiolytic and Sedative Activities of Methanol Extract of Solanum aethiopicum (Linn.) Fruits in Swiss Mice

2021

TJNPR

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Anxiety is a group of mental disorders characterized by the sudden feeling of intense fear, panic, shortness of breath, chest pain, insomnia, fatigue, sweating, etc. 1 Anxiety disorders (AD) include generalized anxiety disorder, panic disorder, agoraphobia, obsessive compulsive disorder (OCD), social anxiety disorder, specific phobia, post-traumatic stress disorders (PSTD), separation anxiety disorder and selective mutism. 1 Anxiety disorder occurs as a result of response to stress which causes release of cortisol and noradrenaline. These hormones activate amygdala and limbic system connected to the prefrontal cortex in the brain. The disorder is mediated in the central nervous system via GABA, norepinephrine, serotonin, dopamine and glycine receptors. 2,3 Treatment involves the use of anxiolytic agents such as benzodiazepines, carbamates, atypical antipsychotics, azapirones, and antidepressants. 2,3 Medicinal plants are widely used in the phytotherapy of various CNS disorders including anxiety. 4-6 Various part of the plants such as leaves, stems, roots, fruits, seeds, flowers etc. were used by both traditional and orthodox medicine practitioners as their source of medication. 4-6 The application of

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Section: Resultsmentioning

confidence: 99%