Dynamic maceration of Matricaria chamomilla inflorescences: optimal conditions for flavonoids and antioxidant activity

Pereira, Simone Vieira; Reis, Rayssa A.S.P.; Garbuio, Danielle Cristina; Freitas, Luís Alexandre Pedro de

doi:10.1016/j.bjp.2017.11.006

Cited by 29 publications

(19 citation statements)

References 28 publications

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“…In general, liquid-liquid or solid-liquid extraction is the most widely used process for the extraction of flavonoids. Although maceration and water infusion are conventional extraction processes, they are still used today [35,36]. These methodologies have adopted the use of solvents such as ethanol, methanol, acetone and not just water for the extraction of bioactive compounds [14,37,38].…”

Section: Conventional Methodsmentioning

confidence: 99%

Conventional and Emerging Extraction Processes of Flavonoids

et al. 2020

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Flavonoids are a group of plant constituents called phenolic compounds and correspond to the nonenergy part of the human diet. Flavonoids are found in vegetables, seeds, fruits, and beverages such as wine and beer. Over 7000 flavonoids have been identified and they have been considered substances with a beneficial action on human health, particularly of multiple positive effects because of their antioxidant and free radical scavenging action. Although several studies indicate that some flavonoids have provident actions, they occur only at high doses, confirming in most investigations the existence of anti-inflammatory effects, antiviral or anti-allergic, and their protective role against cardiovascular disease, cancer, and various pathologies. Flavonoids are generally removed by chemical methods using solvents and traditional processes, which besides being expensive, involve long periods of time and affect the bioactivity of such compounds. Recently, efforts to develop biotechnological strategies to reduce or eliminate the use of toxic solvents have been reported, reducing processing time and maintaining the bioactivity of the compounds. In this paper, we review, analyze, and discuss methodologies for biotechnological recovery/extraction of flavonoids from agro-industrial residues, describing the advances and challenges in the topic.

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Section: Conventional Methodsmentioning

confidence: 99%

Conventional and Emerging Extraction Processes of Flavonoids

et al. 2020

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“…The effect of concentration (A), stirring rate (B), and extraction time (C) on extraction response is theoretically expected to increase yield and polyphenolic compounds (rich-EGCG). The specified extraction factor or variable strongly supports polyphenol compounds to dissolve well [18][19][20]. In order to obtain high levels of EGCG and polyphenols, a strategy is needed in regulating the material ratio with solvent, temperature, stirring rate, and extraction time.…”

Section: Resultsmentioning

confidence: 99%

“…Extraction techniques such as conventional maceration and infundation have an equilibrium point [18]. Likewise, with the KAI technique developed.…”

Section: Resultsmentioning

confidence: 99%

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Optimization of a Novel Kinetic-Assisted Infundation for Rich-Egcg and Polyphenols of White Tea (Camellia Sinensis) Using Central Composite Design

Shiyan¹,

Hertiani²,

Martien³

et al. 2018

Int J App Pharm

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Objective: This research aimed to find modeling and optimization of a novel kinetic-assisted infundation for rich-epigallocatechin gallate (EGCG) and polyphenols extraction from white tea leaf (Camellia sinensis L.).Methods: The optimal conditions for the best extraction of kinetic-assisted infundation were determined using central composite design. The content of EGCG, catechin, gallic acid, caffeine, theobromine, and theophylline was quantified using high-performance liquid chromatography with ultraviolet detection (HPLC/UV-detection). The total polyphenolic content (TPC) and total flavonoid content (TFC) was measured using the spectrophotometric method. The semi-purified extract was characterized by HPLC, fourier transform infrared spectrophotometry-universal attenuated total reflectance (FTIR-UATR), and powder-X ray diffraction (P-XRD). The extraction mechanism of target compounds was analyzed using scanning electron microscopy (SEM) qualitatively.Results: The optimum process for the rich-EGCG and polyphenolic extraction using kinetic-assisted infundation was the concentration of simplicia 14.75 %, the stir rate 440 rpm, and extraction time 12.31 min. The yield of extracts, TPC, TFC, EGCG, caffeine, gallic acid, and theobromine contents in the optimal extraction process were 9.34 %, 70.97 %, 13.95 %, 29.02 %, 11.95 %, 1.33 %, and 0.33 %, respectively.Conclusion: The kinetic-assisted infundation method proved to be easy to apply with good results as an alternative technique for extracting polyphenolic compounds and rich-EGCG from white tea leaves.

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“…Also, include sinapic acid which acts as antioxidant 25 , cinnamic acid acts as anticancer, antioxidant 26,27 , coumaric acid acts as antibacterial, immunomodulatory, antioxidant activity [28][29][30][31] . Flavonoid compounds such as myricetin show anti-atherosclerotic show, antiinflammatory 32,33 , Apigenin acts as antioxidant, anti-hyperglycaemic, anti-inflammatory, antiapoptotic, cytotoxic, cardiovascular [34][35][36][37][38][39] . Quercetin acts as antiatherosclerotic 40 .…”

Section: Fig 12: Zone Of Inhibition Of Different Extracts Of a Aspementioning

confidence: 99%

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2020

IJPSR

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Green synthesis is one of the best routes for the silver nanoparticles (AgNPs). The present study revealed that the aqueous leaf extracts of Aeschynomene aspera, which contains alkaloids, flavonoids, phenols, terpenoids, anthocyanidins, indoles, glycosides, saponins and tannins, is found to be responsible for bioreduction during the synthesis of silver nanoparticles (SNPs). The colour change from light yellow to dark brown within 20 to 60 min indicates the formation of nanoparticles. The UV-Visible spectrum of the aqueous medium containing silver nanoparticles showed a Surface Plasmon Resonance peak at 450 nm. FT-IR analysis reveals that the phenols and amides are mainly responsible for reduction. XRD analysis clearly showed the characteristic Bragg peaks of (111), (200), (220), (311) facets of the face-entered cubic structure of silver nanoparticles and confirmed that these nanoparticles are crystalline in nature.HR-TEM analysis revealed that the green synthesized SNPs were spherical in shape with an average size of 10 nm. The antibacterial effect of synthesized AgNPs on different bacterial strains with the zone of inhibition 14.1 mm on Escherichia coli 12.2 mm on Pseudomonas aeruginosa, 11.3 mm on Staphylococcus aureus and 11.1 mm on Bacillus subtilis respectively. DPPH analysis shows that the nanoparticles possess 67.48 percent of antioxidant activity. The above results also correlated with the other species of Fabaceae such as, Abrus precatorius, Cicer arietinum, Callindra haematocephala Clitoria ternatea, and Pongamia pinnata both in their nanoparticles characteristics and also their antibacterial activity.

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Dynamic maceration of Matricaria chamomilla inflorescences: optimal conditions for flavonoids and antioxidant activity

Cited by 29 publications

References 28 publications

Conventional and Emerging Extraction Processes of Flavonoids

Conventional and Emerging Extraction Processes of Flavonoids

Optimization of a Novel Kinetic-Assisted Infundation for Rich-Egcg and Polyphenols of White Tea (Camellia Sinensis) Using Central Composite Design

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