Musanga cecropioides leaf extract exhibits anti-inflammatory and anti-nociceptive activities in animal models

Momordica balsamina Fruit Extracts Enhances Selected Aspects of the Insulin Synthesis/Secretion Pathway

“…On the other hand, the upregulation of glucokinase mRNA levels was observed only at 50 µg/mL concentration. The observation that a crude plant extract may have a biological effect at a lower concentration than at a higher concentration have been stated in previous researches (Karthikeyan et al, 2010;Sowemimo et al, 2015;Zandi et al, 2016), however, no suitable explanation has been brought forward to account for this observation. Interestingly, it was also detected in this aspect of the study that the crude MB fruit ethanol extract which did not enhance the uptake of glucose in concentration dependent manner by RIN-m5F cells, significantly upregulated the expression of both glucokinase and GLUT2 genes.…”

Anti-Inflammatory Activity of Methanolic Leaf Extract of Kigelia Africana (Lam.) Benth and Stem Bark Extract of Acacia Hockii De Wild in Mice

“…A similar study carried out by [38], evaluated for the anti-inflammatory activity of Cissus quadrangularis using a dose range of 50 mg/kg, 100 mg/kg, and 150 mg/kg body weight in rats. Similarly, a study carried out on the anti-inflammatory activity of leaf extract of Musanga cecropioides used a dose range of 50 mg/kg, 100 mg/kg, 150 mg/kg, and 200 mg/kg [39].…”

An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

“…Antimicrobial, Antimalarial, Anti-Cancer (Trabelsi et al, 2014;Khodabakhsh et al, 2015 ;Bapna et al, 2014;Sharma et al, 2008;Karimi et al, 2012 ) Simaroubaceae: Quassia amara L. Apers et al, 2002;Toma et al, 2003;Kupchan et al, 1976;Toma et al, 2002) Urticaceae Sowemimo et al, 2015 ;Aziba 2004 ;Ajayi et al, 2013 ;Emoji et al, 2014) water ethanol extract of MC stem bark at 300 mg/kg bw reduced significantly glucose-load induced hyperglycemia in normal wistar rats and at 200, 300, and 400 mg/kg bw in STZ-induced diabetic rats. The extract effects were less efficient than those of glibenclamide (Nyunaï et al, 2016 Acute toxicity: 5 Groups of rats were treated orally or by IP with 300, 600, 1200, 2400 and 4800…”

“…to mice. LD 50 >3 g/kg (Sowemimo et al, 2015) Subacute toxicity: Daily oral dose of 750 mg/kg bw was administered to rats for 28 days. No subacute toxicity up to 750 mg/kg bw was recorded (Adeneye et al, 2006) Alkaloids, phenolic compounds, catechic tanins, flavonoids, and triterpenes (Nyunaï et al, 2016) Verbenaceae: Lantana camara L.…”