An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

Taika, B. Bading; Bouckandou, M.; Souza, Alain; Bourobou, H.P. Bourobou; Mackenzie, Louise; Lione, Lisa

doi:10.1016/j.jep.2017.12.036

Cited by 23 publications

(3 citation statements)

References 226 publications

(115 reference statements)

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“…These plants were Mondia whitei and compounds 5-chloropropacin, 7-hydroxy-4,6-dimethoxypropacin and propacin; Voacanga Africana and its compounds ibogaine, ibogamine, iboxygaine, vinburnine, voacamine, voacangine, voacorine, voaphylline and vobtusine; and Xysmalobium undulatum and compounds allouzarin, alloxysmalorin, uzarigenin, uzarin (Figure 3). Of note, these three plants have been used traditionally to treat diabetes, but lack the accompanying scientific evidence [68,69,70]. The identification of the compounds found in these plants with a potential anti-diabetic activity provide some rationale for the traditional use of these plants in the treatment of diabetes.…”

Section: Resultsmentioning

confidence: 99%

Exploring African Medicinal Plants for Potential Anti-Diabetic Compounds with the DIA-DB Inverse Virtual Screening Web Server

et al. 2019

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Medicinal plants containing complex mixtures of several compounds with various potential beneficial biological effects are attractive treatment interventions for a complex multi-faceted disease like diabetes. In this study, compounds identified from African medicinal plants were evaluated for their potential anti-diabetic activity. A total of 867 compounds identified from over 300 medicinal plants were screened in silico with the DIA-DB web server (http://bio-hpc.eu/software/dia-db/) against 17 known anti-diabetic drug targets. Four hundred and thirty compounds were identified as potential inhibitors, with 184 plants being identified as the sources of these compounds. The plants Argemone ochroleuca, Clivia miniata, Crinum bulbispermum, Danais fragans, Dioscorea dregeana, Dodonaea angustifolia, Eucomis autumnalis, Gnidia kraussiana, Melianthus comosus, Mondia whitei, Pelargonium sidoides, Typha capensis, Vinca minor, Voacanga africana, and Xysmalobium undulatum were identified as new sources rich in compounds with a potential anti-diabetic activity. The major targets identified for the natural compounds were aldose reductase, hydroxysteroid 11-beta dehydrogenase 1, dipeptidyl peptidase 4, and peroxisome proliferator-activated receptor delta. More than 30% of the compounds had five or more potential targets. A hierarchical clustering analysis coupled with a maximum common substructure analysis revealed the importance of the flavonoid backbone for predicting potential activity against aldose reductase and hydroxysteroid 11-beta dehydrogenase 1. Filtering with physiochemical and the absorption, distribution, metabolism, excretion and toxicity (ADMET) descriptors identified 28 compounds with favorable ADMET properties. The six compounds—crotofoline A, erythraline, henningsiine, nauclefidine, vinburnine, and voaphylline—were identified as novel potential multi-targeted anti-diabetic compounds, with favorable ADMET properties for further drug development.

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Section: Resultsmentioning

confidence: 99%

Exploring African Medicinal Plants for Potential Anti-Diabetic Compounds with the DIA-DB Inverse Virtual Screening Web Server

et al. 2019

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“…Traditional healers in the province of Estuaire (Gabon) use the air-dried root bark or its maceration for treatment of diabetes (Souza et al, 2011). Mechanistic studies of iboga extracts suggest a potential use for management of diabetes mellitus (Souza et al, 2011; Bading-Taika et al, 2018), which represents one of the most prevalent metabolic disorders resulting from defects in insulin secretion, insulin action, or both. This metabolic disorder leads to microvascular (retinopathy, neuropathy and nephropathy) and macrovascular (heart attack, stroke and peripheral vascular disease) complications (Umar et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Several bioactives of plant origin exhibit antidiabetic activity or insulin mimetic activity. They include polyphenols, tannins, alkaloids, carbohydrates, terpenoids, coumarins, steroids and flavonoids (Atta Ur and Zaman, 1989; Firdous, 2014; Patel et al, 2012; Bading-Taika et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice

Bading-Taika¹,

Akinyeke²,

Magaña³

et al. 2018

JFB

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Preparations of the root bark of Tabernanthe iboga have long been used in Central and West African traditional medicine to combat fatigue, as a neuro-stimulant in rituals, and for treatment of diabetes. The principal alkaloid of T. iboga, ibogaine, has attracted attention in many countries around the world for providing relief for opioid craving in drug addicts. Using a plant metabolomics approach, we detected five phenolic compounds, including 3-O-caffeoylquinic acid, and 30 alkaloids, seven of which were previously reported from T. iboga root bark. Following a report that iboga extracts contain insulinotropic agents, we aimed to determine the potential alleviating effects of the water extract of iboga root bark on high-fat diet (HFD)-induced hyperglycemia as well as its effects on cognitive function in male C57BL/6J mice. Feeding a HFD to mice for 10 weeks produced manifestations of metabolic syndrome such as increased body weight and increased plasma levels of glucose, triacylglycerols, total cholesterol, LDL-cholesterol, insulin, leptin, and pro-inflammatory mediators (IL-6, MCP-1, ICAM-1), as compared to mice fed a low-fat diet (LFD). Supplementation of HFD with iboga extract at ibogaine doses of 0.83 (low) and 2.07 (high) mg/kg/day did not improve these HFD-induced metabolic effects except for a reduction of plasma MCP-1 in the low dose group, indicative of an anti-inflammatory effect. When the HFD mice were tested in the water maze, the high-dose iboga extract caused hippocampus-dependent impairments in spatial learning and memory, as compared to mice receiving only a HFD.

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Enhancement in the production of phenolic compounds from Fagonia indica callus cultures via Fusarium oxysporum triggered elicitation

Khan,

Javed,

Mahmood

et al. 2024

In Vitro Cell.Dev.Biol.-Plant

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An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

Abstract: An in-depth understanding on the pharmacology and toxicology of Gabonese anti-diabetic plants is lacking yet there is a great scope for new treatments. With further research, the use of Gabonese anti-diabetic plants is important to ensure the safety of the diabetic patients in Gabon.

Cited by 23 publications

References 226 publications

Exploring African Medicinal Plants for Potential Anti-Diabetic Compounds with the DIA-DB Inverse Virtual Screening Web Server

Exploring African Medicinal Plants for Potential Anti-Diabetic Compounds with the DIA-DB Inverse Virtual Screening Web Server

Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice

Enhancement in the production of phenolic compounds from Fagonia indica callus cultures via Fusarium oxysporum triggered elicitation

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