Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice

Bading-Taika, Bayissi; Akinyeke, Tunde; Magaña, Armando Alcázar; Choi, Jaewoo; Ouanesisouk, Michael; Torres, Eileen Ruth S.; Lione, Lisa; Maier, Christoph; Bobe, Gerd; Raber, Jacob; Miranda, Cristobal L.; Stevens, Jan F.

doi:10.31665/jfb.2018.3154

Cited by 9 publications

(4 citation statements)

References 34 publications

(45 reference statements)

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“…For metabolites with MS/MS confirmation, only those metabolites with MS/MS fragment scores higher than 30 were considered credibly identified [ 25 ]. In the Progenesis QI workflow, we considered confidence scores higher than 50 sufficient for assignment of constituents in the iboga extract [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

Urinary metabolomics reveals the biological characteristics of early pregnancy in pigs

et al. 2022

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Background Embryo implantation in sows is an important event during pregnancy. During this process, blastocysts undergo dramatic morphologic changes, and the endometrium becomes receptive. Studies have shown that developmental changes associated with the crosstalk between peri-implantation embryos and embryo-uterine are driven by various biomolecules secreted by the endometrium and embryos. In sows, changes in the uterus are also reflected in circulating body fluids and urine. Metabolomics reveals the metabolic state of cells, tissues, and organisms. In this study, we collected urine samples from large white sows during the peri-implantation period. The levels of urinary metabolites at different periods were analyzed using ultra-performance liquid chromatography/tandem mass spectrometry (UPLC–MS/MS) analysis techniques. Results A total of 32 samples were collected from 8 sows during the estrus period and at each phase of early pregnancy (9, 12, and 15 days of gestation). A total of 530 metabolites were identified with high confidence in all samples. Compared with samples collected during the estrus phase, 269 differential metabolites were found in samples obtained during early pregnancy. Conclusions The identified metabolites included lipids and lipid-like molecules, organic acids and their derivatives, organic oxygen compounds, organoheterocyclic compounds, benzenoids, among others. Metabolites, such as choline and pregnanediol-3-glucuronide, play important roles in pregnancy in sows and other animals. These results reveal the metabolic changes in urine of sows during early pregnancy phase. The differential urinary metabolites can be used for assessing peri-implantation status in sows. Understanding these metabolic changes may promote the management of pregnant sows through various interventions such as provision of proper nutrition.

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Section: Methodsmentioning

confidence: 99%

Urinary metabolomics reveals the biological characteristics of early pregnancy in pigs

et al. 2022

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“…In addition, the instrument was equipped with an automatic calibrant delivery system performing calibration every two hours. Annotation of compounds was performed as previously reported with some modifications [ 44 , 45 , 46 ]. In brief, exact mass, isotopic pattern, and MS/MS spectra were compared with online libraries: MassBank of North America (MoNA), METLIN, and Human Metabolome Database (HMDB) (online versions, July 2021).…”

Section: Methodsmentioning

confidence: 99%

Composition of Pinot Noir Wine from Grapevine Red Blotch Disease-Infected Vines Managed with Exogenous Abscisic Acid Applications

et al. 2022

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Grapevine red blotch disease (GRBD) has negative effects on grape development and impacts berry ripening. Abscisic acid (ABA) is a plant growth regulator involved in the initiation of berry ripening. Exogenous abscisic acid application was compared to an unsprayed control on GRBD-positive Pinot noir vines during two vintages, and the total monomeric anthocyanin, total phenolics, phenolic composition, and volatile profile were measured in wines. In addition, untargeted metabolites were profiled using high-resolution LC-MS/MS. Results showed that the wine composition varied by vintage year and was not consistent with ABA application. Wines from the ABA treatment had a lower total anthocyanin and total phenolic content in one year. The untargeted high-resolution LC-MS/MS analysis showed a higher abundance of phenolic compounds in ABA wines in 2019, but lower in 2018. The wine volatile compounds of ABA treatments varied by vintage. There were higher levels of free β-damascenone, β-ionone, nerol, and several fermentation-derived esters, acids, and alcohols in ABA wines, but these were not observed in 2019. Lower 3-isobutyl-2-methoxypyrazine (IBMP) was also observed in wines with ABA treatment in 2019. The results demonstrated that ABA application to the fruit zones did not consistently mitigate the adverse impacts of GRBD on Pinot noir wines.

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“…All data presented herein were obtained from refs. [44,54,55,70,72,74,75,78,88,95,96,98,102–111,116,119–121,124–130,132,134–137,140–144,147–156,158,159,161,163–171,173–176...…”

Section: Diet Composition and Exposure Timementioning

confidence: 99%

“…All data presented herein were obtained from refs. [70,72,74,77,78,88,95,96,98,104,105,107,109–112,114–128,130,132,133,135–142,144–146,148,150,151,153,154,157,159,161–168,174,176–184,187,188,190,191,194,196–198,200–204,206,208–212,215,217,219–226,229,230,232–235,237,239–242,244,250–253,257,258,263,264,266–268,270–276,278,285,287–290,292,295,296,298–301,303,304,308–310,314,316,317,319,321,322,324,325,329,331–342].…”

Section: Diet Composition and Exposure Timementioning

confidence: 99%

Modeling Diet‐Induced Metabolic Syndrome in Rodents

Leonardi

Gosmann

Zimmer

2020

Molecular Nutrition Food Res

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Standardized animal models represent one of the most valuable tools available to understand the mechanism underlying the metabolic syndrome (MetS) and to seek for new therapeutic strategies. However, there is considerable variability in the studies conducted with this essential purpose. This review presents an updated discussion of the most recent studies using diverse experimental conditions to induce MetS in rodents with unbalanced diets, discusses the key findings in metabolic outcomes, and critically evaluates what we have been learned from them and how to advance in the field. The study includes scientific reports sourced from the Web of Science and PubMed databases, published between January 2013 and June 2020, which used hypercaloric diets to induce metabolic disorders, and address the impact of the diet on metabolic parameters. The collected data are used as support to discuss variables such as sex, species, and age of the animals, the most favorable type of diet, and the ideal diet length to generate metabolic changes. The experimental characteristics propose herein improve the performance of a preclinical model that resembles the human MetS and will guide researchers to investigate new therapeutic alternatives with confidence and higher translational validity.

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Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice

Cited by 9 publications

References 34 publications

Urinary metabolomics reveals the biological characteristics of early pregnancy in pigs

Urinary metabolomics reveals the biological characteristics of early pregnancy in pigs

Composition of Pinot Noir Wine from Grapevine Red Blotch Disease-Infected Vines Managed with Exogenous Abscisic Acid Applications

Modeling Diet‐Induced Metabolic Syndrome in Rodents

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