Characterization of intestinal absorption of C -glycoside flavonoid vicenin-2 from Lychnophora ericoides leafs in rats by nonlinear mixed effects modeling

Buqui, Gabriela Amaral; Sy, Sherwin K. B.; Merino-Sanjuán, Matilde; Gouvea, Dayana Rubio; Nixdorf, Suzana Lucy; Kimura, Elza; Derendorf, Hartmut; Lopes, Norberto P.; Diniz, Andréa

doi:10.1016/j.bjp.2015.04.001

Cited by 14 publications

(8 citation statements)

References 19 publications

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“…They reported the first‐order absorption rate constant as 0.274 min −1 and zero‐order rate constant as 16.3 min −1 . The investigators also noted that approximately 40% of the original dose of vicenin‐2 was rapidly absorbed in the small intestine . The pharmacokinetic studies of fenugreek and its safety profile, either used alone or in combination with other natural products, have been reported in literature .…”

Section: Bioavailability Of Active Compoundsmentioning

confidence: 98%

“…Buqui et al. utilized nonlinear mixed effects model to study the absorption pharmacokinetic parameters of vicenin‐2, with the assumption of first‐order absorption and zero‐order secretion. They reported the first‐order absorption rate constant as 0.274 min −1 and zero‐order rate constant as 16.3 min −1 .…”

Section: Bioavailability Of Active Compoundsmentioning

confidence: 99%

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A small plant with big benefits: Fenugreek (Trigonella foenum‐graecum Linn.) for disease prevention and health promotion

Venkata

Swaroop²,

Bagchi

et al. 2017

Molecular Nutrition Food Res

156

102

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Plant-derived natural products have long-standing utility toward treating degenerative diseases. It is estimated that about two-thirds of world population depend on traditional medicine for primary medical needs. Fenugreek (Trigonella foenum-graecum Linn.), a short-living annual medicinal plant belonging to Fabaceae family, is used extensively in various parts of the world as herb, food, spice, and traditional medicine. Fenugreek is considered as one of the oldest medicinal plants and its health-promoting effects have been cited in Ayurveda and traditional Chinese medicine. The investigations into the chemical composition and pharmacological actions have seen a renaissance in recent years. Extensive preclinical and clinical research have outlined the pharmaceutical uses of fenugreek as antidiabetic, antihyperlipidemic, antiobesity, anticancer, anti-inflammatory, antioxidant, antifungal, antibacterial, galactogogue and for miscellaneous pharmacological effects, including improving women's health. The pharmacological actions of fenugreek are attributed to diverse array of phytoconstituents. The phytochemical analysis reveals the presence of steroids, alkaloids, saponins, polyphenols, flavonoids, lipids, carbohydrates, amino acids, and hydrocarbons. This review aims to summarize and critically analyze the current available literature to understand the potential of fenugreek for disease prevention and health improvement with special emphasis on cellular and molecular mechanisms. Current challenges and new directions of research on fenugreek are also discussed.

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Section: Bioavailability Of Active Compoundsmentioning

confidence: 98%

Section: Bioavailability Of Active Compoundsmentioning

confidence: 99%

A small plant with big benefits: Fenugreek (Trigonella foenum‐graecum Linn.) for disease prevention and health promotion

Venkata

Swaroop²,

Bagchi

et al. 2017

Molecular Nutrition Food Res

156

102

View full text Add to dashboard Cite

show abstract

“…Buqui et al. ( 2015 ) investigated the absorption of vicenin‐2 in male Wistar rats using the in situ single‐pass intestinal perfusion technique after oral administration of 180 mg/kg bw. The calculated absorption in 30 min was about 40%.…”

Section: Assessmentmentioning

confidence: 99%

“…In the Caco-2 cell line model, Gouvea et al (2014) showed that vicenin-2 did not permeate the cells, suggesting a poor absorption in vivo. Buqui et al (2015) investigated the absorption of vicenin-2 in male Wistar rats using the in situ single-pass intestinal perfusion technique after oral administration of 180 mg/kg bw. The calculated absorption in 30 min was about 40%.…”

Section: Vicenin-2mentioning

confidence: 99%

Safety and efficacy of a feed additive consisting of an aqueous extract of Citrus limon (L.) Osbeck (lemon extract) for use in all animal species (Nor‐Feed SAS)

Additives¹,

Bampidis²,

Azimonti³

et al. 2021

EFS2

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Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of an aqueous extract of Citrus limon (L.) Osbeck (lemon extract) when used as a sensory additive in feed for all animal species. The FEEDAP Panel concluded that the additive under assessment is safe for all animal species up to the maximum proposed use levels of 1,000 mg/kg complete feed and 250 mg/kg water for drinking. No concerns for consumers were identified following the use of lemon extract up to the highest safe level in feed. The additive should be considered a skin and eye irritant, and a potential corrosive. The use of the extract in animal feed under the proposed conditions was not expected to pose a risk for the environment. Lemon extract was recognised to flavour food. Since its function in feed would be essentially the same as that in food, no further demonstration of efficacy was considered necessary.

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“…[15] Studies also provided the evidence that almost 40% of the original dosage of vicenin-2 was quickly absorbed in the small intestine. [16] The glycoside has many beneficial effects in living organisms. The bioavailability of this compound is very important to play the role as antioxidant as well as anti-inflammatory in living organisms.…”

Section: Bio-availability Of Active Compounds Of Fenugreekmentioning

confidence: 99%

Nutritional and therapeutic properties of fenugreek (Trigonella foenum-graecum): a review

Syed

Rashid

Ahmad

et al. 2020

International Journal of Food Properties

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Current lifestyle, eating habits, stress, environmental factors and intensive use of synthetic chemicals in food processing and agriculture have radically increased the progression of several human diseases. Globally, researchers have been looking for natural therapeutic substances that can be used to treat or delay the onset of these lifestyle-related disorders. Numerous types of medicinal plants have shown the potential to be frequently used in the therapeutics due to the presence of several bioactive compounds. Among these, fenugreek is an important herb which has been recognized as an imperative medicinal plant by various scientists around the world. This herb has been widely reported as beneficial against numerous diseases such as cancer, hypercholesterolemia, diabetes and inflammation. Due to its medicinal value, the extracts/powders from different parts of fenugreek have been effectively utilized in food and pharmaceutical industries. Accordingly, the present review is an attempt to highlight the important nutritional benefits and curative applications of fenugreek as an effectual therapeutic agent against different diseases.

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Characterization of intestinal absorption of C -glycoside flavonoid vicenin-2 from Lychnophora ericoides leafs in rats by nonlinear mixed effects modeling

Cited by 14 publications

References 19 publications

A small plant with big benefits: Fenugreek (Trigonella foenum‐graecum Linn.) for disease prevention and health promotion

A small plant with big benefits: Fenugreek (Trigonella foenum‐graecum Linn.) for disease prevention and health promotion

Safety and efficacy of a feed additive consisting of an aqueous extract of Citrus limon (L.) Osbeck (lemon extract) for use in all animal species (Nor‐Feed SAS)

Nutritional and therapeutic properties of fenugreek (Trigonella foenum-graecum): a review

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