Acute genotoxicity analysis in vivo of the aqueous extract of Maytenus guyanensis Amazonian chichuá

Meneguetti, Dionatas Ulises de Oliveira; Lima, Renato Abreu; Silva, Francisco Carlos da; Passarini, Guilherme Matos; Facundo, João Bezerra; Pagotto, Rubiani de Cássia; Militão, Júlio Sancho Linhares Teixeira; Facundo, Valdir Alves

doi:10.1016/j.bjp.2015.03.003

Cited by 6 publications

(9 citation statements)

References 31 publications

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“…Nobre et al (2014) demonstrated a reduction in the development of lima bean roots in the presence of aqueous extracts of three medicinal plants from Brazil. Meneguetti et al (2014) also reported toxic effects for an aqueous extract of Maytenus guyanensis on A. cepa, subsequently these results was confirmed in tests in mice, demonstrating the effectiveness of tests A. cepa, as compared with other methodological procedures (Meneguetti et al, 2015).…”

Section: Resultsmentioning

confidence: 84%

“…In tropical countries, medicinal plants are an invaluable health source and provide folk medicine with great possibilities to assist conventional treatments and combat diverse types of diseases (Souza et al, 2004). Brazil possesses almost 19% of the world's flora, of which the Amazon Forest is one of the most rich and diversified area on the planet; however, roughly 99% of the medicinal plants do not have its efficacy and pharmacological safety proven, making necessary a phytochemical and pharmacological approach, which may represent a great economic potential to be explored by the pharmaceutical industry (Meneguetti et al, 2015). As a consequence, this region possesses huge biotechnological potential (Souza et al, 2004;Possimoser et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial and phytotoxicity activities of aqueous crude extract from the Amazonian ethnomedicinal plant Bellucia grossularioides (L.) Triana

Martins¹,

Borges²,

Armiato³

et al. 2016

J. Med. Plants Res.

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The use of plants or their parts as alternative therapies for disease is very common in many countries worldwide. Secondary metabolites present in the extracts of certain plants can inhibit or halt the development of certain pathogen species. The present study assessed the possible antimicrobial activities of a popular crude aqueous extract. The aerial parts of the Amazon tree Bellucia grossularioides (L) Triana (popularly known as Muúba or Angry-Jambo) were prepared according to folk recommendations and tested against four microorganisms related to health concerns in three concentrations (20, 10 and 5 mg/ml). The results showed no antimicrobial potential against Staphylococcus aureus, Candida albicans and Candida krusei, which cause furunculosis and leukorrhea, respectively. Additionally, growth inhibition of the toxigenic fungus Aspergillus parasiticus was assayed in vitro and the results showed no inhibitory activity for any of the tested concentrations. These findings contradict the traditional knowledge and may assist the targeting of future therapeutics practices. However, an inhibitory effect was observed for all forms of the preparations and concentrations tested on the roots of Allium cepa, indicating phytotoxic effects.

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Section: Resultsmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Antimicrobial and phytotoxicity activities of aqueous crude extract from the Amazonian ethnomedicinal plant Bellucia grossularioides (L.) Triana

Martins¹,

Borges²,

Armiato³

et al. 2016

J. Med. Plants Res.

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“…Also, a few people had some light nausea. Meneguetti et al [123] found that M. guyanensis did not present genotoxic effects during their animal experiments.…”

Section: Toxic Effectsmentioning

confidence: 96%

A Review on Phytochemicals of the Genus Maytenus and Their Bioactive Studies

Huang

Chen

et al. 2021

Molecules

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The genus Maytenus is a member of the Celastraceae family, of which several species have long been used in traditional medicine. Between 1976 and 2021, nearly 270 new compounds have been isolated and elucidated from the genus Maytenus. Among these, maytansine and its homologues are extremely rare in nature. Owing to its unique skeleton and remarkable bioactivities, maytansine has attracted many synthetic endeavors in order to construct its core structure. In this paper, the current status of the past 45 years of research on Maytenus, with respect to its chemical and biological activities are discussed. The chemical research includes its structural classification into triterpenoids, sesquiterpenes and alkaloids, along with several chemical synthesis methods of maytansine or maytansine fragments. The biological activity research includes activities, such as anti-tumor, anti-bacterial and anti-inflammatory activities, as well as HIV inhibition, which can provide a theoretical basis for the better development and utilization of the Maytenus.

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“…Many compounds isolated from plants have shown promising anti-protozoan activities; these include chalcones, alkaloids, naphthoquinones, lignans, neolignans, and terpenes (1) (2) (3) (4) (5) . However, a large number of medicinal plants remain to be scientifically evaluated and studies have indicated that the active constituents of more than 95% of endemic Brazilian species have not yet been identified (6) (7) (8) . This represents a potentially exploitable pharmacological and economic resource, particularly for Amazonian plant species (8) (9) , many of which have not even been cataloged (10) .…”

Section: Introductionmentioning

confidence: 99%

Screening of the in vitro antileishmanial activities of compounds and secondary metabolites isolated from Maytenus guianensis Klotzsch ex Reissek (Celastraceae) chichuá Amazon

Meneguetti

Lima

Hurtado

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:Maytenus guianensis is a member of the Celastraceae family that is used in traditional medicine, particularly for its anti-parasitic and anti-cancer effects. To explore the ethnopharmacological potential of this plant, the present study was designed to screen the in vitro antileishmanial activities of extracts and compounds isolated from M. guianensis. Methods: Maytenus guianensis stems and leaves were extracted in acetone, followed by the preparation of eluates and isolation of secondary metabolites using chromatography on a glass column with silica gel as the fixed phase. The chemical components were identified using spectroscopic methods, including one-and two-dimensional nuclear magnetic resonance of hydrogen-1 and carbon-13, mass spectroscopy, and infrared spectroscopy. The anti-Leishmania amazonensis activities of these eluates and compounds were evaluated by direct promastigote counting and viability assays. Results: It was found that the hexane bark eluate produced the strongest anti-L. amazonensis effect, with 90-100% inhibition of the promastigote form. The isolated metabolite that produced the best result was tingenone B, followed by a compound formed by the union of tingenone and tingenone B (80-90% inhibition). Conclusions: Maytenus guianensis shows anti-parasite activity that warrants further investigation to determine the mechanisms underlying this antileishmanial effect and to evaluate the pharmacological potential of these eluates and isolated secondary metabolites, while minimizing any adverse effects.

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Acute genotoxicity analysis in vivo of the aqueous extract of Maytenus guyanensis Amazonian chichuá

Cited by 6 publications

References 31 publications

Antimicrobial and phytotoxicity activities of aqueous crude extract from the Amazonian ethnomedicinal plant Bellucia grossularioides (L.) Triana

Antimicrobial and phytotoxicity activities of aqueous crude extract from the Amazonian ethnomedicinal plant Bellucia grossularioides (L.) Triana

A Review on Phytochemicals of the Genus Maytenus and Their Bioactive Studies

Screening of the in vitro antileishmanial activities of compounds and secondary metabolites isolated from Maytenus guianensis Klotzsch ex Reissek (Celastraceae) chichuá Amazon

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