What is the effectiveness of beta-glucan for treatment of acute otitis media?

Çetinkaya, Erdem Atalay; Çiftçi, Osman; Alan, Saadet; Öztanır, Mustafa Namık; Başak, Neşe

doi:10.1016/j.bjorl.2020.02.004

Cited by 4 publications

(2 citation statements)

References 17 publications

(27 reference statements)

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“…In addition to the EGFR protein, other gene proteins also play important roles in the TM healing process. Among these core proteins, IL1B and IL6 participate in the process of histological damage and inflammation, as demonstrated with acute animal models 43,44 45,46 …”

Section: Discussionmentioning

confidence: 93%

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The possible mechanism of Hippophae fructus oil applied in tympanic membrane repair identified based on network pharmacology and molecular docking

Huang

Teh

et al. 2021

Clinical Laboratory Analysis

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Objective This study aimed to explore the mechanisms of Hippophae fructus oil (HFO) in the treatment of tympanic membrane (TM) perforation through network pharmacology‐based identification. Methods The compounds and related targets of HFO were extracted from the TCMSP database, and disease information was obtained from the OMIM, GeneCards, PharmGkb, TTD, and DrugBank databases. A Venn diagram was generated to show the common targets of HFO and TM, and GO and KEGG analyses were performed to explore the potential biological processes and signaling pathways. The PPI network and core gene subnetwork were constructed using the STRING database and Cytoscape software. A molecular docking analysis was also conducted to simulate the combination of compounds and gene proteins. Results A total of 33 compounds and their related targets were obtained from the TCMSP database. After screening the 393 TM‐related targets, 21 compounds and 22 gene proteins were selected to establish the network diagram. GO and KEGG enrichment analyses revealed that HFO may promote TM healing by influencing cellular oxidative stress and related signaling pathways. A critical subnetwork was obtained by analyzing the PPI network with nine core genes: CASP3, MMP2, IL1B, TP53, EGFR, CXCL8, ESR1, PTGS2, and IL6. In addition, a molecular docking analysis revealed that quercetin strongly binds the core proteins. Conclusion According to the analysis, HFO can be utilized to repair perforations by influencing cellular oxidative stress. Quercetin is one of the active compounds that potentially plays an important role in TM regeneration by influencing 17 gene proteins.

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Section: Discussionmentioning

confidence: 93%

“…Among these core proteins, IL1B and IL6 participate in the process of histological damage and inflammation, as demonstrated with acute animal models. 43 , 44 The activity of MMP2 is also hypothesized to be involved in destruction of the TM fibrous layer and the prognosis of otitis media. 45 , 46 …”

Section: Discussionmentioning

confidence: 99%