Olfactory ensheathing cells in facial nerve regeneration

Li, Manyi; Zhu, Qing; Liu, Jisheng

doi:10.1016/j.bjorl.2018.07.006

Cited by 5 publications

(3 citation statements)

References 26 publications

(27 reference statements)

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“…In addition, OECs derived from the olfactory mucosa are closely related to neurons and fibroblasts, while OECs derived from the olfactory bulb are closely related to fibroblasts and astrocytes ( Lakatos et al, 2000 ; Jani and Raisman, 2004 ; Windus et al, 2010 ). Compared with olfactory bulb-derived OECs, olfactory mucosa-derived OECs can promote nerve regeneration more ( Li et al, 2020c ). This means that OECs from different sources may have completely different ability to promote nerve regeneration and the efficacy after transplantation.…”

Section: Biological Characteristics Of Oecsmentioning

confidence: 99%

Olfactory ensheathing cells and neuropathic pain

Liu

Wang

et al. 2023

Front. Cell Dev. Biol.

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Damage to the nervous system can lead to functional impairment, including sensory and motor functions. Importantly, neuropathic pain (NPP) can be induced after nerve injury, which seriously affects the quality of life of patients. Therefore, the repair of nerve damage and the treatment of pain are particularly important. However, the current treatment of NPP is very weak, which promotes researchers to find new methods and directions for treatment. Recently, cell transplantation technology has received great attention and has become a hot spot for the treatment of nerve injury and pain. Olfactory ensheathing cells (OECs) are a kind of glial cells with the characteristics of lifelong survival in the nervous system and continuous division and renewal. They also secrete a variety of neurotrophic factors, bridge the fibers at both ends of the injured nerve, change the local injury microenvironment, and promote axon regeneration and other biological functions. Different studies have revealed that the transplantation of OECs can repair damaged nerves and exert analgesic effect. Some progress has been made in the effect of OECs transplantation in inhibiting NPP. Therefore, in this paper, we provided a comprehensive overview of the biology of OECs, described the possible pathogenesis of NPP. Moreover, we discussed on the therapeutic effect of OECs transplantation on central nervous system injury and NPP, and prospected some possible problems of OECs transplantation as pain treatment. To provide some valuable information for the treatment of pain by OECs transplantation in the future.

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Section: Biological Characteristics Of Oecsmentioning

confidence: 99%

Olfactory ensheathing cells and neuropathic pain

Liu

Wang

et al. 2023

Front. Cell Dev. Biol.

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“…OECs are a special type of glial cell that have the properties of both Schwann cells and astrocytes. OECs can accompany olfactory nerve axons from the peripheral nervous system to the central nervous system and combine with the mitral cells of the OB at the skull base [37]. OECs are the only known glial cells that can cross the barrier between the peripheral and central nerves, and have the ability to regenerate at a mature stage.…”

Section: Biological Characteristics Of Oecsmentioning

confidence: 99%

Research progress on the therapeutic effect of olfactory ensheathing cell transplantation on ischemic stroke

Wang

Zhao

2021

Journal of Neurorestoratology

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Olfactory ensheathing cells (OECs) are a special type of glial cell in the olfactory system, which exhibit neuroprotective, immunomodulatory, and angiogenic effects. Although many studies have focused on the reversal of demyelination and axonal degeneration (during spinal cord injury) by OECs, few reports have focused on the ability of OECs to repair ischemic nerve injury. This article reviews the protective effects of OEC transplantation in ischemic stroke and provides a theoretical basis and new strategy for OEC transplantation in the treatment of ischemic stroke.

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“…Cell therapy, also known as regenerative therapy, uses special types of active cells or their derivatives to improve the repair response of dysfunctional and damaged tissue ( 6 , 7 ). OECs are special glial cells, which can survive and renew in the central nervous system, and have been widely used in nerve regeneration and tissue repair ( 8 , 9 ). OECs therapy usually focuses on cell substitution or environmental enrichment.…”

Section: Introductionmentioning

confidence: 99%

Potential therapeutic effect of olfactory ensheathing cells in neurological diseases: neurodegenerative diseases and peripheral nerve injuries

Zhang,

Liao,

Liu

et al. 2023

Front. Immunol.

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Neurological diseases are destructive, mainly characterized by the failure of endogenous repair, the inability to recover tissue damage, resulting in the increasing loss of cognitive and physical function. Although some clinical drugs can alleviate the progression of these diseases, but they lack therapeutic effect in repairing tissue injury and rebuilding neurological function. More and more studies have shown that cell therapy has made good achievements in the application of nerve injury. Olfactory ensheathing cells (OECs) are a special type of glial cells, which have been proved to play an important role as an alternative therapy for neurological diseases, opening up a new way for the treatment of neurological problems. The functional mechanisms of OECs in the treatment of neurological diseases include neuroprotection, immune regulation, axon regeneration, improvement of nerve injury microenvironment and myelin regeneration, which also include secreted bioactive factors. Therefore, it is of great significance to better understand the mechanism of OECs promoting functional improvement, and to recognize the implementation of these treatments and the effective simulation of nerve injury disorders. In this review, we discuss the function of OECs and their application value in the treatment of neurological diseases, and position OECs as a potential candidate strategy for the treatment of nervous system diseases.

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Olfactory ensheathing cells in facial nerve regeneration

Cited by 5 publications

References 26 publications

Olfactory ensheathing cells and neuropathic pain

Olfactory ensheathing cells and neuropathic pain

Research progress on the therapeutic effect of olfactory ensheathing cell transplantation on ischemic stroke

Potential therapeutic effect of olfactory ensheathing cells in neurological diseases: neurodegenerative diseases and peripheral nerve injuries

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