Research progress on the therapeutic effect of olfactory ensheathing cell transplantation on ischemic stroke

Abstract

Olfactory ensheathing cells (OECs) are a special type of glial cell in the olfactory system, which exhibit neuroprotective, immunomodulatory, and angiogenic effects. Although many studies have focused on the reversal of demyelination and axonal degeneration (during spinal cord injury) by OECs, few reports have focused on the ability of OECs to repair ischemic nerve injury. This article reviews the protective effects of OEC transplantation in ischemic stroke and provides a theoretical basis and new strategy for OEC transplantation in the treatment of ischemic stroke.

Clinical Efficacy of Edaravone and Urinary Kallidinogenase Co-Treatment in Acute Ischemic Stroke

“…Edaravone is widely utilized as a medication in the clinical management of AIS [10,11] . It functions as a free radical scavenger, with a small molecular weight and lipophilic groups that allow it to penetrate the blood-brain barrier and directly act on the lesion site, clearing free radicals and inhibiting lipid peroxidation [12] . These actions help alleviate brain tissue damage and cerebral edema caused by cerebral ischemia [13] .…”