We introduce a novel framework for using natural language to generate and edit 3D indoor scenes, harnessing scene semantics and text-scene grounding knowledge learned from large annotated 3D scene databases. The advantage of natural language editing interfaces is strongest when performing semantic operations at the sub-scene level, acting on groups of objects. We learn how to manipulate these sub-scenes by analyzing existing 3D scenes. We perform edits by first parsing a natural language command from the user and transforming it into a semantic scene graph that is used to retrieve corresponding sub-scenes from the databases that match the command. We then augment this retrieved sub-scene by incorporating other objects that may be implied by the scene context. Finally, a new 3D scene is synthesized by aligning the augmented sub-scene with the user's current scene, where new objects are spliced into the environment, possibly triggering appropriate adjustments to the existing scene arrangement. A suggestive modeling interface with multiple interpretations of user commands is used to alleviate ambiguities in natural language. We conduct studies comparing our approach against both prior text-to-scene work and artist-made scenes and find that our method significantly outperforms prior work and is comparable to handmade scenes even when complex and varied natural sentences are used.

We present a generative neural network that enables us to generate plausible 3D indoor scenes in large quantities and varieties, easily and highly efficiently. Our key observation is that indoor scene structures are inherently hierarchical . Hence, our network is not convolutional; it is a recursive neural network, or RvNN. Using a dataset of annotated scene hierarchies, we train a variational recursive autoencoder , or RvNN-VAE, which performs scene object grouping during its encoding phase and scene generation during decoding. Specifically, a set of encoders are recursively applied to group 3D objects based on support, surround, and co-occurrence relations in a scene, encoding information about objects’ spatial properties, semantics , and relative positioning with respect to other objects in the hierarchy. By training a variational autoencoder (VAE), the resulting fixed-length codes roughly follow a Gaussian distribution. A novel 3D scene can be generated hierarchically by the decoder from a randomly sampled code from the learned distribution. We coin our method GRAINS, for Generative Recursive Autoencoders for INdoor Scenes. We demonstrate the capability of GRAINS to generate plausible and diverse 3D indoor scenes and compare with existing methods for 3D scene synthesis. We show applications of GRAINS including 3D scene modeling from 2D layouts, scene editing, and semantic scene segmentation via PointNet whose performance is boosted by the large quantity and variety of 3D scenes generated by our method.

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MicroRNA-145 (miR-145) has been implicated in several cancers. However, its role in nasopharyngeal carcinoma (NPC) remains unclear. In this study, we proved that miR-145 was significantly downregulated in NPC and associated with NPC cell metastasis. Moreover, miR-145 suppressed Smad3 by directly binding to the 3'-untranslated region (UTR) of Smad3. Knockdown of Smad3 in NPC cells inhibited cell migration and invasion, which was consistent with the effect of miR-145 in NPC cells. In addition, Smad3 expression was inversely correlated with miR-145 level in clinical NPC samples. Taken together, our findings indicate that miR-145 is a tumour suppressor that affects invasive and metastatic properties of NPC via the miR-145/Smad3 axis, leading us to propose that miR-145 overexpression might be a potential therapeutic strategy of NPC intervention.