The evaluation of pretreatment neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio in patients with laryngeal neoplasms

Eskıızmır, Görkem; Uz, Uzdan; Onur, Ece; Özyurt, Beyhan Cengiz; Cikrikci, Gizem Karaca; Şahin, Nevin Hotun; Oran, Arzu; Çelik, Onur

doi:10.1016/j.bjorl.2018.04.013

Cited by 23 publications

(18 citation statements)

References 37 publications

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“…Its 5-year survival rate is approximately 75% in patients with localized disease, 44% in patients with regional disease, and 35% in patients with distant disease. 1 When there is regional or distant metastasis, the 5-year survival rate drops significantly. Laryngeal squamous cell carcinoma accounts for 85% to 95% of all laryngeal carcinomas, and the age of onset for this disease is now earlier than it was in the past.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Analysis of Preoperative Inflammatory Biomarkers in Patients With Laryngeal Squamous Cell Carcinoma

et al. 2019

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Objective: The purpose of this study was to demonstrate the prognostic role of inflammatory biomarkers in patients with laryngeal squamous cell carcinoma. Methods: For this study, we enrolled 151 patients who had undergone surgery for laryngeal squamous cell carcinoma. We assessed the preoperative neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), mean platelet volume, red cell distribution width, and alkaline phosphatase. The chi-square test, Kaplan-Meier survival analysis, and Cox proportional hazards model were conducted on overall survival, progression-free survival, locoregional recurrence-free survival, and distant metastasis-free survival of patients with laryngeal squamous cell carcinoma. Results: Both Kaplan-Meier analysis and univariate analysis showed significant prognostic differences with age, laryngectomy methods, Tumor Node Metastasis (TNM) staging, tumor location, NLR, PLR, MLR, and mean platelet volume. Multivariate analysis indicated that NLR (overall survival: hazard ratio [HR] = 3.02, 95% confidence interval [CI]: 1.28-7.10, P = .011), PLR (overall survival: HR = 0.33, 95% CI: 0.14-0.78, P = .011; progression-free survival: HR = 0.016,95% CI: 0.10-0.79, P = .016), and MLR (overall survival: HR = 0.29, 95% CI: 0.11-0.76, P = .012) were independent prognostic factors for 5-year survival. However, red cell distribution width and alkaline phosphatase had no significant difference in overall survival and progression-free survival. Conclusions: Preoperative high NLR, PLR, and MLR were associated with poor prognosis. They were found to be effective and reliable inflammatory biomarkers for patients with laryngeal squamous cell carcinoma.

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Section: Introductionmentioning

confidence: 99%

Prognostic Analysis of Preoperative Inflammatory Biomarkers in Patients With Laryngeal Squamous Cell Carcinoma

et al. 2019

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“…20,21 However, there are a few studies with different results evaluating the usability of NLR for the differentiation of BG, PG and MG in laryngeal lesions. 10,11,[22][23][24][25] In the present study, it was found that NLR in MG laryngeal was statistically higher than BG laryngeal lesions. However, in PG lesions, NLR was not different from BG and MG groups.…”

Section: Discussionmentioning

confidence: 73%

Comparison of Neutrophil Lymphocyte Ratio in Benign, Premalignant and Malignant Laryngeal Lesions

Çolak¹,

YAĞMUR²,

Çufalı³

et al. 2022

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Benign (BG), premalignant (PG) and malignant (MG) lesions can be seen in the laryngeal mucosa as a result of exposure to physical, chemical and biological agents. BG lesions are nodules, polyps or cysts, often caused by excessive use of the voice or vocal cord trauma. 1 Laryngeal MG lesions are most frequently seen due to tobacco use. The most com-mon histopathological type is squamous cell carcinoma and it is the most common tumor in the head and neck region. According to the data of the United States of America for 2017, there were 13,360 new cases and 3,660 deaths due to laryngeal cancer. 2,3 While MG transformation is not observed in BG lesions of the larynx, the development of laryngeal

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“…Bu ilişkiden dolayı lenfosit düzeyi ile hastalığın ciddiyeti korelasyon göstermektedir. 16 Damar ve ark., Cheng ve ark., Kawakita ve ark., Seng ve ark., ile Kuzucu ve ark.nın yaptıkları çalışmalarda, NLR ve PLR'yu malign lezyonlarda daha yüksek olarak saptanmıştır. 1,15,[17][18][19] Malign parotis tümörlü hastalarda, benign parotis tümörlü hastalara göre yüksek NLR, yüksek nötrofil yüzdesi, düşük lenfosit sayısı ve düşük lenfosit yüzdesi saptanmıştır.…”

Section: Bulgularunclassified

The Value of Inflammatory Parameters in the Differantial Diagnosis of “Benign” and “Malignant” Lesions in Parotid Gland Tumors

Özdemir¹,

Birinci²,

Bedir³

et al. 2019

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The evaluation of pretreatment neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio in patients with laryngeal neoplasms

Abstract: Pretreatment neutrophil-lymphocyte ratio is a useful and reliable predictive and prognostic biomarker for patients with laryngeal carcinoma.

Cited by 23 publications

References 37 publications

Prognostic Analysis of Preoperative Inflammatory Biomarkers in Patients With Laryngeal Squamous Cell Carcinoma

Prognostic Analysis of Preoperative Inflammatory Biomarkers in Patients With Laryngeal Squamous Cell Carcinoma

Comparison of Neutrophil Lymphocyte Ratio in Benign, Premalignant and Malignant Laryngeal Lesions

The Value of Inflammatory Parameters in the Differantial Diagnosis of “Benign” and “Malignant” Lesions in Parotid Gland Tumors

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