Investigation of neutrophil-to-lymphocyte ratio and mean platelet volume in sudden hearing loss

Kum, Rauf Oğuzhan; Özcan, Müge; Baklacı, Deniz; Kum, Nurcan Yurtsever; Yılmaz, Yavuz; Ünal, Adnan; Avci, Yonca

doi:10.1016/j.bjorl.2015.08.009

Cited by 38 publications

(47 citation statements)

References 43 publications

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“…In particular, Seo et al (2014) and Kum et al (2015) showed lower values of lymphocyte count in patients with less than 15 dB HL of hearing gain with respect to the initial hearing loss. Masuda et al (2012), _ Ikinciogullar{ et al (2014) and Quaranta et al (2015) instead did not observe any correlation between lymphocyte count and recovery rate.…”

Section: Discussionmentioning

confidence: 82%

“…On the contrary, Sagit et al (2013) and Seo et al (2014) analysing, respectively, haematological data of 31 and 348 SSNHL patients evidenced a significant difference in PC values between subjects with and without SSNHL. Furthermore, Yasan et al (2013), Wittig et al (2014), Quaranta et al (2015), Kum et al (2015) did not recognise PC as prognostic factor for hearing recovery (p40.05).…”

Section: Discussionmentioning

confidence: 95%

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Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Salvago

Rizzo

Bianco

et al. 2016

International Journal of Audiology

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Objective: To investigate the relationship between haematological routine parameters and audiogram shapes in patients affected by sudden sensorineural hearing loss (SSNHL). Design: A retrospective study. All patients were divided into four groups according to the audiometric curve and mean values of haematological parameters (haemoglobin, white blood cell, neutrophils and lymphocytes relative count, platelet count, haematocrit, prothrombin time, activated partial thromboplastin time, fibrinogen and neutrophil-to-lymphocite ratio) of each group were statistically compared. The prognostic role of blood profile and coagulation test was also examined. Study sample: A cohort of 183 SSNHL patients without comorbidities. Results: With a 48.78% of complete hearing recovery, individuals affected by upsloping hearing loss presented a better prognosis instead of flat (18.36%), downsloping (19.23%) and anacusis (2.45%) groups (p ¼ 0.0001). The multivariate analysis of complete blood count values revealed lower mean percentage of lymphocytes (p ¼ 0.041) and higher platelet levels (p ¼ 0.015) in case of downsloping hearing loss; with the exception of fibrinogen (p ¼ 0.041), none of the main haematological parameters studied resulted associated with poorer prognosis. Conclusions: Our work suggested a lack of association between haematological parameters and a defined audiometric picture in SSNHL patients; furthermore, only fibrinogen seems to influence the prognosis of this disease.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 95%

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Salvago

Rizzo

Bianco

et al. 2016

International Journal of Audiology

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“…6, 21 On the other hand, given that according to previous studies, cardiac ischemic events are associated with some platelet parameters such as mean platelet volume.…”

Section: Discussionmentioning

confidence: 98%

Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Novel Markers for Diagnosis of Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis

Bahrami

Ansari

Ara³

et al. 2016

Bali Med J.

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Background: Sudden sensorineural hearing loss (SSNHL) is a common otologic disease characterized by a loss of hearing greater than 30 dB in three consecutive frequencies which occurs in less than 72 hours. Objective: To investigate the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) on sudden sensorineural hearing loss (SSNHL). Search strategy: A PubMed, Science Direct, Scopus, OVID, EMBASE and Google Scholar search (date last searched April 2016) without any time, language and location restriction was done. Inclusion criteria: All case-control studies, which have been investigated the relationship of NLR and PLR with the occurrence of SSNHL were included in our meta-analysis.Results: A total of 5 case-control studies were included in the study. All 5 studies have been reported NLR of patients and control groups (611 patients and 804 controls). Our analysis showed that the mean NLR of patients is 1.12 (0.82-1.43) unit higher than that of controls with 95% CI which is statistically significant. Also, 3 studies have been reported PLR of patients and control groups (512 patients and 705 controls). Our analysis showed that the mean PLR of patients is 0.57 (0.08-1.05) unit higher than that of controls with 95% CI which is statistically significant too. Conclusions: This meta-analysis confirmed the relationship of NLR and PLR with SSNHL. Therefore, these parameters can be considered as new markers in diagnosis of SSNHL.Keywords: Sudden sensorineural hearing loss, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio Cite This Article: Bahrami, M., Ansari, A., Chaman-Ara, K., Bahrami, E., Bahrami, S., Bahrami, M., Barati, O., Moosazadeh, M., Guzhan Kum, R. 2016. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as novel markers for diagnosis of sudden sensorineural hearing loss: a systematic review and meta-analysis.

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“…It is valuable as expensive inflammatory markers, such as IL-6, IL-1β, IL-8, and TNF-α 18 . In recent studies, the value of NLR has been also studied in the diagnosis and the prognosis of ISSHL [19][20][21][22][23][24] . The higher levels of NLR in unrecovered patients of ISSHL was explained with the higher inflammation situation of these patients 19,23 .…”

Section: Biochemical and Hematological Analysesmentioning

confidence: 99%

“…In recent studies, the value of NLR has been also studied in the diagnosis and the prognosis of ISSHL [19][20][21][22][23][24] . The higher levels of NLR in unrecovered patients of ISSHL was explained with the higher inflammation situation of these patients 19,23 . Therefore, in these studies, NLR was suggested as a quick and reliable indicator for diagnosis and prognosis of ISSHL [19][20][21]23 .…”

Section: Biochemical and Hematological Analysesmentioning

confidence: 99%

A Bit Exagerrated Role Of Complete Blood Count Parameters On The Prognosis Of Idiopathic Sudden Sensorineural Hearing Loss

Deveci

Toraman

et al. 2016

JOA

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Idiopathic sudden sensorineural hearing loss (ISSHL) is a commonly seen otorhinolaryngology emergency, and its etiology is still a mystery. In this retrospective clinical study, we aimed to investigate the possible relationship of inflammatory markers derived from CBC such as neutrophil-to-lymphocyte ratio (NLR), plateletto-lymphocyte ratio (PLR), Red cell distribution width-to-platelet ratio (RPR), lymphocyte-to-monocyte ratio (LMR), mean platelet volume (MPV) and platelet distribution width (PDW) in ISSHL . A total of 50 idiopathic sudden hearing loss patients were included in the study. They were grouped according to their hearing healing levels as recovered, partially recovered and unrecovered. Also 47 age-and sex-matched healthy individuals created the control group. Their complete blood count parameters of NLR, LMR, PLR, RPR, PDW and MPV were recorded. The results were statistically compared to bring out a significant difference between the groups.There was no significant demographic difference between the groups. The comparison of patient group with control group reveal a significant difference in the NLR, LMR and PDW values (p<0.05). The remaining values were not statistically significant. The analysis of these values according to the recovery level of the ISSHL, there was no statistical difference between the groups (p>0.05). We demonstrated for the first time that LMR value was significantly elevated in ISSHL patients. NLR, LMR, and PDW might be indicative for diagnosis of ISSHL. However, we believe that using these parameters for the screening of the prognosis is a clinically useless exercise. DOI : 10.14302/issn.2379-8572.joa-16-1366Corresponding Author: Hande Senem Deveci, Fatih Sultan Mehmet Education and Research Hospital E-5 Karayolu uzeri Bostanci, Istanbul, Turkey, Email: senemesen@yahoo.com Keywords: idiopathic sudden sensorineural hearing loss, neutrophil-to-lymphocyte ratio, platelet-tolymphocyte ratio, Red cell distribution width-to-platelet ratio, lymphocyte-to-monocyte ratio, mean platelet volume and platelet distribution width.

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Investigation of neutrophil-to-lymphocyte ratio and mean platelet volume in sudden hearing loss

Abstract: Neutrophil-to-lymphocyte ratio is a quick and reliable indicator regarding diagnosis and prognosis of sudden hearing loss; on the other hand, mean platelet volume may be considered a less important indicator in this aspect.

Cited by 38 publications

References 43 publications

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Novel Markers for Diagnosis of Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis

A Bit Exagerrated Role Of Complete Blood Count Parameters On The Prognosis Of Idiopathic Sudden Sensorineural Hearing Loss

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