Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Novel Markers for Diagnosis of Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis

Abstract

Background: Sudden sensorineural hearing loss (SSNHL) is a common otologic disease characterized by a loss of hearing greater than 30 dB in three consecutive frequencies which occurs in less than 72 hours. Objective: To investigate the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) on sudden sensorineural hearing loss (SSNHL). Search strategy: A PubMed, Science Direct, Scopus, OVID, EMBASE and Google Scholar search (date last searched April 2016) without any time, language and location restriction was done. Inclusion criteria: All case-control studies, which have been investigated the relationship of NLR and PLR with the occurrence of SSNHL were included in our meta-analysis.Results: A total of 5 case-control studies were included in the study. All 5 studies have been reported NLR of patients and control groups (611 patients and 804 controls). Our analysis showed that the mean NLR of patients is 1.12 (0.82-1.43) unit higher than that of controls with 95% CI which is statistically significant. Also, 3 studies have been reported PLR of patients and control groups (512 patients and 705 controls). Our analysis showed that the mean PLR of patients is 0.57 (0.08-1.05) unit higher than that of controls with 95% CI which is statistically significant too. Conclusions: This meta-analysis confirmed the relationship of NLR and PLR with SSNHL. Therefore, these parameters can be considered as new markers in diagnosis of SSNHL.Keywords: Sudden sensorineural hearing loss, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio Cite This Article: Bahrami, M., Ansari, A., Chaman-Ara, K., Bahrami, E., Bahrami, S., Bahrami, M., Barati, O., Moosazadeh, M., Guzhan Kum, R. 2016. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as novel markers for diagnosis of sudden sensorineural hearing loss: a systematic review and meta-analysis.

Difference of Complete Blood Count (CBC) between Patient with Sudden Deafness and Control at Sanglah General Hospital from January 2018-March 2021

“…Several studies have been conducted on the relationship between MPV and sudden deafness, but there are no consistent and conclusive results. According to [12], there was no significant difference between the MPV values of cases and controls.…”

“…From the results of this study, there was a difference between NLR in cases and controls (p<0.05). According to [12] the mean NLR in cases was significantly higher than in controls (p<0.05). According to [1] neutrophils are a thrombogenic marker, and a risk factor for stroke and myocardial infarction.…”

Neutrophil-to-lymphocyte ratio and red cell distribution width: potential inflammatory markers for sudden sensorineural hearing loss

“…In our study, NLR was significantly higher than in the control group and it is strong evidence that inflammation plays a role in the etiology of the disease. In the study byBahrami et al, the strong relationship between the emergence of SSHL and NLR in the meta-analysis was determined [19]. Therefore, this parameter is related to the emergence of the disease and it is important in a bad response to the treatment.…”