Histologic correlation of expression of Ki-67 in squamous cell carcinoma of the glottis according to the degree of cell differentiation

Bonhin, Rodrigo Gonzalez; Carvalho, Guilherme Machado de; Guimarães, Alexandre Caixeta; Chone, Carlos Takahiro; Crespo, Agrício Nubiato; Altemani, Albina; Amstalden, Eliane Maria Ingrid

doi:10.1016/j.bjorl.2014.05.016

Cited by 17 publications

(13 citation statements)

References 16 publications

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“…For other cancerous lesions it had been shown that expression of MIB-1 indicated aggressive malignant disease with poor survival prognosis,35 36 poor grading37 and a higher risk for recurrent disease within the first year 38. As expected, high MIB-1 expression levels showed significantly negative correlation to survival in our study.…”

Section: Discussionsupporting

confidence: 83%

Prognostic relevance of epithelial–mesenchymal transition and proliferation in surgically treated primary parotid gland cancer

et al. 2016

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Section: Discussionsupporting

confidence: 83%

Prognostic relevance of epithelial–mesenchymal transition and proliferation in surgically treated primary parotid gland cancer

et al. 2016

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“…Meanwhile, non-significant correlation was detected with tumor size, metastasis and clinical stage. This is supported with the findings of Bonhin et al [37] and Kim et al [38] who found a significant positive correlation between Ki-67 cell proliferation and histological tumor differentiation of squamous cell carcinoma. In addition, Kim et al [38] stated that Ki-67 expression was significantly associated with lymph node involvement of their studied SCCs.…”

Section: Discussionsupporting

confidence: 89%

The impact of proliferation and cancer stem cell upon the resistence to chemotherapy in salivary mucopepidermoid carcinoma

Esmaeil

Ahmed

Mourad

et al. 2019

JST

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Background and aim: Mucoepidermoid carcinoma is a common salivary tumor that affects both adults and children. Proliferation is one of the most fundamental biological processes of growth and maintenance of tissue homeostasis. CD-44 may be used as an indicator of aggressive behavior of some human malignancy. Multidrug resistance is one of the major obstacles for successful cancer chemotherapy. The present study was carried out for evaluation of the biological rules and the clinicopathological significance of Ki-67, CD-44 and MDR-1 expression in the different histopathological grades of MECs.Patients and methods: Eighty paraffin embedded MEC tissues were collected and classified to three groups according to their histological grades. Tissue sections were stained with Ki-67, CD-44 and MDR-1 then examined microscopically and analyzedstatistically.Result: High grade MEC cases showed the highest expression for Ki-67, CD-44 and MDR-1. Additionally, significant differences were found between the histopathological grades as well as between lymph node stages of the studied cases and the expression of the three utilized markers.Conclusion: Ki-67, CD-44 and MDR-1can be used to evaluate the degree of differentiation and to predict the prognosis of MECs, furthermore, high grade MEC cases with high proliferative indices might be resistant to chemotherapy.

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“…According to a Brazilian research 2 , the evaluation by optical microscopy of growth speed of mitotic figures stained with HE is not a high-accuracy method, since it is impossible to show which cells have entered the cell division cycle, because G1, S and G2 phases of cell life cycle are not identified by optical microscopy. Therefore, the analysis in this study shows to be doubtful too, even that there was equilibrium between the groups.…”

Section: Discussionmentioning

confidence: 99%

Tranexamic Acid Action on Liver Regeneration After Partial Hepatectomy: Experimental Model in Rats

Sobral

Daga

Rasera

et al. 2016

ABCD, arq. bras. cir. dig.

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Background: Different lesions may affect the liver resulting in harmful stimuli. Some therapeutic procedures to treat those injuries depend on liver regeneration to increase functional capacity of this organ. Aim: Evaluate the effects of tranexamic acid on liver regeneration after partial hepatectomy in rats. Method: 40 rats (Rattus norvegicus albinus, Rodentia mammalia) of Wistar-UP lineage were randomly divided into two groups named control (CT) and tranexamic acid (ATX), with 20 rats in each. Both groups were subdivided, according to liver regeneration time of 32 h or seven days after the rats had been operated. The organ regeneration was evaluated through weight and histology, stained with HE and PCNA. Results: The average animal weight of ATX and CT 7 days groups before surgery were 411.2 g and 432.7 g, and 371.3 g and 392.9 g after the regeneration time, respectively. The average number of mitotic cells stained with HE for the ATX and CT 7 days groups were 33.7 and 32.6 mitosis, and 14.5 and 14.9 for the ATX and CT 32 h groups, respectively. When stained with proliferating cell nuclear antigen, the numbers of mitotic cells counted were 849.7 for the ATX 7 days, 301.8 for the CT 7 days groups, 814.2 for the ATX 32 hand 848.1 for the CT 32 h groups. Conclusion: Tranexamic acid was effective in liver regeneration, but in longer period after partial hepatectomy.

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Histologic correlation of expression of Ki-67 in squamous cell carcinoma of the glottis according to the degree of cell differentiation

Abstract: The cell proliferation index, as measured by Ki-67, may be useful in the characterization of histological degree in glottic squamous cell tumors.

Cited by 17 publications

References 16 publications

Prognostic relevance of epithelial–mesenchymal transition and proliferation in surgically treated primary parotid gland cancer

Prognostic relevance of epithelial–mesenchymal transition and proliferation in surgically treated primary parotid gland cancer

The impact of proliferation and cancer stem cell upon the resistence to chemotherapy in salivary mucopepidermoid carcinoma

Tranexamic Acid Action on Liver Regeneration After Partial Hepatectomy: Experimental Model in Rats

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